Genetic risk factor for abdominal aortic aneurysm: HLA-DR2(15), A Japanese study

Hirose, Hitoshi; Takagi, M; Miyagawa, Naotaka; Hashiyada, Hiroshi; Noguchi, Manabu; Tada, Seiichi; Kugimiya, Toshiyasu; Tilson, M. David

doi:10.1016/s0741-5214(98)70324-6

Cited by 49 publications

(27 citation statements)

References 9 publications

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“…An association of HLA-DRB1 alleles (HLA-DR2*15 and *16, *12 and *13) was described by Tilson et al 57 and Rasmussen et al (HLA-DRB1*04 and *15). 58 The presence of the DR␤Gln(70) residue was identified as a risk factor for AAA.…”

Section: Association Of Hla Alleles With Aaamentioning

confidence: 79%

Aortic Aneurysms

2008

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Section: Association Of Hla Alleles With Aaamentioning

confidence: 79%

Aortic Aneurysms

2008

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“…These findings were supported by Monux whose results did not reach statistical significance, but suggested HLA-DR B 1 *01 to be protective and HLA-DR Bl*04 to predispose to AAA (Monux 2003). Increased frequency of the HLA-DR2(15) allele has also been described amongst aneurysm patients compared with controls (58.7% vs 28%) in a Japanese population (Hirose 1998).…”

Section: Nitric Oxide Synthasementioning

confidence: 84%

The role of the CCR5 Δ32 polymorphism in abdominal aortic aneurysms

Sandford¹,

Bown²,

London³

et al. 2009

Int J Immunogenetics

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All rights reserved INFORMATION TO ALL U SE R S The quality of this reproduction is d ep endent upon the quality of the copy submitted.In the unlikely event that the author did not sen d a com plete manuscript and there are m issing p a g es, th e se will be noted. Also, if material had to be removed, a note will indicate the deletion. Dissertation Publishing UMI U 526187Published by ProQ uest LLC 2013. Copyright in the Dissertation held by the Author. Microform Edition © ProQ uest LLC. All rights reserved. This work is protected against unauthorized copying under Title 17, United States C ode. ProQ uest LLC 789 East Eisenhow er Parkway P.O. Box 1346 Ann Arbor, Ml 48106-1346 ST A TEM EN T O F O R IG IN A LIT YI hereby declare that the work contained in this thesis is entirely my own, except where acknowledged, and has not been submitted for a degree to this or any other University. R.M.Sandford A B ST R A C T The Role o f the CCR5 A 32 Polymorphism in Abdominal Aortic Aneurysms By R.M.SandfordC-C Chemokine receptor 5 (CCR5) is involved in the regulation o f the inflammatory response. Abdominal aortic aneurysms (AAA) may arise as the result o f a chronic inflammatory process which is influenced by a genetic predisposition. The CCR5 gene harbours a 32 base pair deletion (the A32 polymorphism, rs333). The aim o f this study was to investigate the role o f the CCR5 A32 polymorphism in the development of AAA.A case control study was conducted including 285 patients with AAA and 273 control subjects. A blood sample was taken from each individual and DNA extracted. CCR5 genotype was determined using the polymerase chain reaction (PCR). Flow cytometry was used to investigate the biological activity o f the A32 polymorphism.There was no significant difference between the AAA and the control group in relation to the A32 allele frequency (AAA group 10%, control group 12%, P=0.82, chi squared analysis). There was also no significant difference in CCR5 genotype between groups (wild type homozygotes 82% in AAA group vs 77% in control group, heterozygotes 16% in AAA group vs 21% in control group, and A32 homozygotes 2% in both groups, P=0.33, chi squared analysis). The polymorphism was shown to be biologically active with the number o f A32 alleles correlating with cell expression of CCR5 as detected with flow cytometry (P=<0.05).This study demonstrates that the CCR5 A32 is a biologically active genetic polymorphism, however, there is no association between this polymorphism and AAA. Firstly, to Professor Rob Sayers for allowing me the opportunity to undertake this research and also for his supervision and support throughout the project. P U B L IC A T IO N S A R IS IN G FROM T H IS T H E S ISSandford DM Diabetes Mellitus DNAAlso, to Mr M iff Bown for his friendship, patience and encouragement in addition to providing statistical and scientific support. Demographic data 103 Table 7.2: Patient and control subject co-morbidity 105 Table 7.3: Patient and control group medication 106 Table 7.4: Univariate analysis of demog...

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“…In a Japanese population, an increased frequency of the HLA-DR2(15) allele has been demonstrated in aneurysm patients. Other studies have shown HLA-DR B1*02 and B1*04 subtypes as well as HLA-A2 and HLA-B61 antigens to be more common in AAA patients (Rasmussen et al, 2002;Monux et al, 2003;Hirose et al, 1998). Despite this, a more recent study of 241 AAA patients failed to demonstrate a risk association between AAA and these alleles suggesting that the role of these particular genes and the autoimmune component in AAA etiology does not appear to be as crucial as previously proposed (Badger et al, 2007).…”

Section: Human Leukocyte Antigen Genesmentioning

confidence: 84%