Genetic resistance to infections in sheep

Bishop, Stephen

doi:10.1016/j.vetmic.2015.07.013

Cited by 27 publications

(26 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…). The economic impacts of the disease are significant (Bishop ), and it has been estimated that at least 40% of sheep flocks in Switzerland are infected (https://www.blv.admin.ch). Because footrot is a multifactorial disease, its clinical representation depends not only on the individual resistance/susceptibility of the host but also on pathogen factors as well as environmental components (Emery et al .…”

Section: Statistics For the Three Lead Single Nucleotide Polymorphismmentioning

confidence: 99%

“…It has been demonstrated that footrot resistance/susceptibility is a heritable trait and that some breeds, such as Romney sheep, are more resistant to the disease than are others (Emery et al . ; Bishop ). An association with major histocompatibility complex genotypes has been suggested and implemented into the Lincoln footrot gene marker test (Bennett & Hickford ).…”

Section: Statistics For the Three Lead Single Nucleotide Polymorphismmentioning

confidence: 99%

See 1 more Smart Citation

A genome‐wide significant association on chromosome 2 for footrot resistance/susceptibility in Swiss White Alpine sheep

et al. 2017

View full text Add to dashboard Cite

Footrot is one of the most important causes of lameness in global sheep populations and is characterized by a bacterial infection of the interdigital skin. As a multifactorial disease, its clinical representation depends not only on pathogen factors and environmental components but also on the individual resistance/susceptibility of the host. A genetic component has been shown in previous studies; however, so far no causative genetic variant influencing the risk of developing footrot has been identified. In this study, we genotyped 373 Swiss White Alpine sheep, using the ovine high-density 600k SNP chip, in order to run a DNA-based comparison of individuals with known clinical footrot status. We performed a case-control genome-wide association study, which revealed a genome-wide significant association for SNP rs418747104 on ovine chromosome 2 at 81.2 Mb. The three best associated SNP markers were located at the MPDZ gene, which codes for the multiple PDZ domain crumbs cell polarity complex component protein, also known as multi-PDZ domain protein 1 (MUPP1). This protein is possibly involved in maintaining the barrier function and integrity of tight junctions. Therefore, we speculate that individuals carrying MPDZ variants may differ in their footrot resistance/susceptibility due to modified horn and interdigital skin integrity. In conclusion, our study reveals that MPDZ might represent a functional candidate gene, and further research is needed to explore its role in footrot affected sheep.

show abstract

Section: Statistics For the Three Lead Single Nucleotide Polymorphismmentioning

confidence: 99%

Section: Statistics For the Three Lead Single Nucleotide Polymorphismmentioning

confidence: 99%

A genome‐wide significant association on chromosome 2 for footrot resistance/susceptibility in Swiss White Alpine sheep

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Similarly, clinical impact caused by benign D nodosus was reported from a wild-range alpine ibex colony in Switzerland [32]. Therefore, further research is required to determine whether the PCR classification used in this study corresponds to clinical presentation, if considered as elimination tool in other species like goats or other populations, since the genetic background of the host also plays a role [33]. If clinical disease expression and PCR results match each other, the test is a useful diagnostic tool for early diagnosis of virulent D nodosus at the flock level and can support veterinarians to distinguish between footrot and interdigital inflammations of other cause at an early stage of disease, when clinical signs are not definite [14].…”

Section: Discussionmentioning

confidence: 85%

The prevalence of Dichelobacter nodosus in clinically footrot-free sheep flocks: a comparative field study on elimination strategies

Kraft

Ströbel²,

Hilke³

et al. 2020

BMC Vet Res

View full text Add to dashboard Cite

Background: Ovine footrot caused by Dichelobacter nodosus (D nodosus) is an infectious disease affecting sheep worldwide. Switzerland plans a nationwide footrot eradication program, based on PCR-testing of interdigital swab samples. The aim of this study was to test for the presence of D nodosus in clinically footrot-free sheep flocks which had been subjected to different treatment strategies, to assess whether they were feasible for the eradication process, especially focussing on antimicrobial flock treatments. Clinical scoring and PCR-results were compared. Ten farms had used hoof bathing and hoof trimming without causing bleeding, ten had used individual treatments and flock vaccines to gain the free status and ten had become free through whole-flock systemic macrolide treatment. For every farm, three risk-based collected pool samples were analysed for the occurrence of virulent and benign D nodosus by PCR detection of aprV2/aprB2. Results: Six flocks from any treatment group tested positive for aprB2 in all pools. Clinical signs were absent at the time of sampling, but some flocks had experienced non-progressive interdigital inflammation previously. Two flocks tested aprV2-positive in the high-risk pool. One of them underwent a progressive footrot outbreak shortly after sampling. Individual retesting indicated, that virulent D nodosus most likely was reintroduced by a recently purchased ram. In the second flock, a ram was tested positive and treated before clinical signs occurred. Conclusions: All treatment strategies eliminated the causative agent and were found to be suitable for implementation in the PCR-based eradication process. PCR-testing proved to be more sensitive than visual scoring, as it also detected clinically healthy carriers. It will be of benefit as a diagnostic tool in elimination and surveillance programs.

show abstract

“…Response to infectious pathogens and susceptibility to disease are traits exhibiting considerable host genetic variation (Bishop, 2015). Studies of genetic variation underlying disease resistance in small ruminants have showed that selection for resistance to certain diseases is possible (Bishop and Morris, 2007).…”

Section: Disease Resistancementioning

confidence: 99%

Genetic improvement of indigenous Greek sheep and goat breeds

Argyriadou¹,

Gelasakis²,

Banos³

et al. 2020

J Hellenic Vet Med Soc

View full text Add to dashboard Cite

The objective of the study was twofold: (i) to review the genetics of production and resilience traits of indigenous Greek small ruminant breeds as well as the evolution of national breeding programs, and (ii) explore innovative and feasible approaches to overcome the challenges and constraints towards improving these breeds and enhancing the sustainability of the small ruminant sector. Previous studies on the genetic basis of production and resilience traits of indigenous breeds revealed high improvement potential. However, the lack of follow-up action has failed to produce applicable results. Thus, implementation of scientific findings in existing breeding programs for these breeds is extremely limited. The latter has contributed to the overall poor success of such programs. Furthermore, due to the fact that most farmers do not comprehend the strategic importance of genetic improvement and lack motivation for self-funding, breeding programs have mostly relied on European or government funding; the latter has resulted in intermittent implementation. Therefore, most programs failed to improve performance of indigenous Greek breeds, many of which were consequently replaced by foreign breeds of higher productivity and documented merit. In order to facilitate the design of breeding schemes and overcome the challenges towards improvement of indigenous breeds, an integrative approach is necessary. The latter should be based on identification of specific breeding objectives, reflecting the priorities and needs of the sector, as well as the capacity of the indigenous populations. Scientific advances exemplified by genomic selection and novel reproductive technologies will enable faster and more effective genetic improvement. The overall approach is expected to enhance the competitiveness of indigenous Greek small ruminant breeds and the sustainability of the sector.

show abstract

Genetic resistance to infections in sheep

Cited by 27 publications

References 47 publications

A genome‐wide significant association on chromosome 2 for footrot resistance/susceptibility in Swiss White Alpine sheep

A genome‐wide significant association on chromosome 2 for footrot resistance/susceptibility in Swiss White Alpine sheep

The prevalence of Dichelobacter nodosus in clinically footrot-free sheep flocks: a comparative field study on elimination strategies

Genetic improvement of indigenous Greek sheep and goat breeds

Contact Info

Product

Resources

About