Genetic relationships of body composition, serum leptin, and age at puberty in gilts12

Kuehn, L. A.; Nonneman, Dan; Klindt, J.; Wise, T.

doi:10.2527/jas.2008-0936

Cited by 36 publications

(32 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This proposal is compatible with our results, which showed significant correlations between basal levels of plasma leptin and body weight. Other recent studies reported that plasma leptin levels increase with age (Kuehn et al 2009;Ganji et al 2009), also compatible with our results. We found that a 20-min exercise regimen had a significant effect on the levels of ghrelin and leptin in young and middle-aged male rats.…”

Section: Discussionsupporting

confidence: 95%

Aging effects on exercise-induced alternations in plasma acylated ghrelin and leptin in male rats

et al. 2010

View full text Add to dashboard Cite

Ghrelin and exercise have been known to stimulate the release of growth hormone which is related to the glucose metabolism. However, the age effects of exercise on ghrelin in energy consumption remain unclear. Young (3 month old) and middle-aged (12 month old) Sprague-Dawley male rats were overnight fasted, and then randomly partitioned into exercise and control groups. Exercise groups swam for 20 min in 25°C water. Rats immersed in 25°C water for 20 min were used as control animals. All blood samples were collected before and 10, 20, 30, and 60 min after initiation of exercise via the right jugular vein. Our results indicated that the swimming regimen decreased the secretion of acylated ghrelin and insulin, but increased the secretion of leptin, lactate, and glucose. In addition, exercise significantly amplified the inverse correlation between leptin and acylated ghrelin (r < -0.6) in middle-age group. Both the above findings were not emphasized in related articles before. Moreover, the time courses of these changes were slightly different in young and middle-aged rats. In basal metabolic characteristics, body weight and the plasma lactate, glucose, insulin, and leptin are higher in middle-age group than that in young group. In conclusion, compared with young rats, middle-aged rats have higher basal body weight, plasma glucose, insulin, and leptin, but age had no effect on the level of plasma acylated ghrelin. A 20-min exercise regimen decreased acylated ghrelin and increased leptin with inverse correlation between them which was strengthened during exercise, but were not influenced by age.

show abstract

Section: Discussionsupporting

confidence: 95%

Aging effects on exercise-induced alternations in plasma acylated ghrelin and leptin in male rats

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Meishan gilts typically reach puberty around 100 d of age (Christenson, 1993;Faillace et al, 1994); whereas typical WC gilts reach puberty around 200 d of age (Kuehn et al, 2009). As a result, MS gilts similar in age to the WC gilts used in this experiment had a greater Gastrointestinal tract content, g 117.3 ± 13.8 69.1 ± 7.9 84.2 ± 9.0 67.2 ± 7.7 0.13 a,b Within a row, means without a common superscript differ (P ≤ 0.05).…”

Section: Discussionmentioning

confidence: 99%

Contributions of the maternal uterine environment and piglet genotype on weaning survivability potential: I. Development of neonatal piglets after reciprocal embryo transfers between Meishan and White crossbred gilts1,2

Miles

Vallet

Ford

et al. 2012

Journal of Animal Science

View full text Add to dashboard Cite

ABSTRACT:In commercial pigs, the greatest susceptibility for pre-weaning mortality occurs in low birth-weight piglets. Despite their overall decreased birth weight, Meishan (MS) piglets have decreased preweaning mortality rates compared with contemporary Western breeds. The objective of the current study was to determine the contributions of the maternal uterine environment, piglet genotype, and their interaction on the development of neonatal piglets pertaining to preweaning survivability using reciprocal embryo transfer between MS and White crossbred (WC) pigs. Twentyfi ve successful pregnancies were produced from 2 farrowing seasons, generating litters of maternal uterine environment (MUE) by piglet genotype (PigG) combinations; MS × MS (n = 4 litters), MS × WC (n = 7 litters), WC × MS (n = 7 litters), and WC × WC (n = 7 litters). At approximately 24 h of age (Day 1), piglets (n = 173) were weighed and a blood sample was taken. Hematocrit, hemoglobin, glucose, plasma urea nitrogen, albumin, NEFA, lactate, and cortisol were measured in all blood samples. Representative piglets (n = 46) from each litter were harvested and body measurements (i.e., organ weights, tissue glycogen content, and body composition) were determined. Piglet data were analyzed by ANOVA using MIXED model procedures. Both MUE (P < 0.001) and PigG (P < 0.01) affected piglet BW, illustrating that piglets gestated in WC gilts were heavier than piglets gestated in MS gilts, and WC piglets were heavier than MS piglets. Serum albumin concentrations were increased (P < 0.05) in MS piglets compared with WC piglets, indicating greater liver maturity. Signifi cant MUE × PigG interactions were observed for hematocrit and hemoglobin, in which the greatest concentrations were observed in MS piglets gestated in MS and WC gilts, and the lowest concentrations were observed in WC piglets gestated in WC gilts, demonstrating increased oxygen-carrying capability. The percentage of fat and nitrogen, as well as the GE of the body, were greater (P < 0.05) in MS piglets, indicating greater energy stores. Liver, bicep femoris, and LM glycogen concentrations were greater (P < 0.01) in WC piglets compared with MS piglets, demonstrating increased glycogen catabolism in MS piglets. This study demonstrated limited interactions between the maternal uterine environment and piglet genotype on weaning survivability potential, suggesting that the MS piglet is a viable model for pre-weaning survivability.

show abstract

“…Previous studies have associated some polymorphisms found in the gene encoding the leptin receptor to some reproductive characteristics in swines (Chen et al, 2004) or to the concentration of circulating leptin (Kuehn et al, 2009). Apart from these findings, the leptin receptor has been thought to be indirectly related to obesity since it controls appetite.…”

Section: Discussionmentioning

confidence: 89%

Comparative study of leptin and leptin receptor gene expression in different swine breeds

et al. 2014

View full text Add to dashboard Cite

ABSTRACT.Leptin is an important regulator of appetite, energy metabolism, and reproduction and is mainly synthesized in the adipocytes and then secreted into the bloodstream. The leptin receptor was classified as type I cytokine receptor due to its structural homology with IL-6 receptors and the signaling pathways in which they are both involved. The aim of our study is to comparatively assess the gene expression levels of leptin (lep) and leptin receptor (lepr) in different swine breeds specialized either in meat production (Duroc, Belgian Landrace, Large White, Synthetic Lines LS-345, and LSP-2000) or fat production (Mangalitsa) in order to correlate them with morphological and productivity characteristics. Additionally, lepr pattern of expression was evaluated comparatively between different tissue types in the Mangalitsa breed. Our results revealed high expression of the lep gene in Mangalitsa compared to those of all the other breeds, while for the lepr gene, average/medium levels were registered in Mangalitsa and increased pattern of expression was found in the synthetic lines LS-345 and LSP-2000. Regarding the comparative analysis of lepr gene expression in various tissues in the Mangalitsa breed, elevated levels were found in the liver and kidney, while the lowest expression was identified in the brain and muscles. Our results suggest that the 7140-7148 (2014) Mangalitsa population exhibits leptin resistance, which might be correlated with atypical morpho-productive characteristics for this breed, such as below-average prolificacy and a strong tendency to accumulate fat.

show abstract

Genetic relationships of body composition, serum leptin, and age at puberty in gilts12

Cited by 36 publications

References 34 publications

Aging effects on exercise-induced alternations in plasma acylated ghrelin and leptin in male rats

Aging effects on exercise-induced alternations in plasma acylated ghrelin and leptin in male rats

Contributions of the maternal uterine environment and piglet genotype on weaning survivability potential: I. Development of neonatal piglets after reciprocal embryo transfers between Meishan and White crossbred gilts1,2

Comparative study of leptin and leptin receptor gene expression in different swine breeds

Contact Info

Product

Resources

About