Genetic relationships between southeastern Spain and Morocco: New data on ABO, RH, MNSs, and DUFFY polymorphisms

Fernández-Santander, Ana; Kandil, Mostafa; Luna, Florencia; Esteban, Esther; Giménez, F.; Zaoui, Driss; Moral, Pedro

doi:10.1002/(sici)1520-6300(199911/12)11:6<745::aid-ajhb4>3.0.co;2-w

Cited by 22 publications

(9 citation statements)

References 6 publications

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“…When compared to other North African populations, the frequencies of FYA and FYB alleles are similar to that observed in the Tunisian people [44,65], while the allelic frequency of FYB ES and the lack of FYX are similar to what is observed in Morocco [66]. Overall, FYA and FYB alleles are mainly represented in Europe, while the allele FYB ES is predominant in Africa [37].…”

Section: Discussionsupporting

confidence: 74%

Vivax malaria in Mauritania includes infection of a Duffy-negative individual

Wurtz

Lekweiry

Bogreau

et al. 2011

Malar J

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BackgroundDuffy blood group polymorphisms are important in areas where Plasmodium vivax is present because this surface antigen is thought to act as a key receptor for this parasite. In the present study, Duffy blood group genotyping was performed in febrile uninfected and P. vivax-infected patients living in the city of Nouakchott, Mauritania.MethodsPlasmodium vivax was identified by real-time PCR. The Duffy blood group genotypes were determined by standard PCR followed by sequencing of the promoter region and exon 2 of the Duffy gene in 277 febrile individuals. Fisher's exact test was performed in order to assess the significance of variables.ResultsIn the Moorish population, a high frequency of the FYBES/FYBES genotype was observed in uninfected individuals (27.8%), whereas no P. vivax-infected patient had this genotype. This was followed by a high level of FYA/FYB, FYB/FYB, FYB/FYBES and FYA/FYBES genotype frequencies, both in the P. vivax-infected and uninfected patients. In other ethnic groups (Poular, Soninke, Wolof), only the FYBES/FYBES genotype was found in uninfected patients, whereas the FYA/FYBES genotype was observed in two P. vivax-infected patients. In addition, one patient belonging to the Wolof ethnic group presented the FYBES/FYBES genotype and was infected by P. vivax.ConclusionsThis study presents the Duffy blood group polymorphisms in Nouakchott City and demonstrates that in Mauritania, P. vivax is able to infect Duffy-negative patients. Further studies are necessary to identify the process that enables this Duffy-independent P. vivax invasion of human red blood cells.

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Section: Discussionsupporting

confidence: 74%

Vivax malaria in Mauritania includes infection of a Duffy-negative individual

Wurtz

Lekweiry

Bogreau

et al. 2011

Malar J

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“…Although the demographic impact of this conquest is a controversial issue, it is not unlikely that a certain degree of population admixture might have happened. In this way, previous studies from classical polymorphisms on the same Moroccan population under study (Fernández-Santander et al 1999;Kandil et al 1999) and from short tandem repeat markers in other population samples (Bosch et al 1999) support differential gene flow into South Iberia.…”

Section: Discussionsupporting

confidence: 61%

“…The position of the examined Moroccan population within the genetic landscape of Mediterranean populations has been previously focused through such classical markers as blood groups (Fernández-Santander et al 1999) and enzyme polymorphisms . These data are consistent with a certain degree of demographic impact of the long historic Arabic presence in the Iberian Peninsula.…”

mentioning

confidence: 99%

Twenty Nuclear DNA Polymorphisms in a Moroccan Population: A Comparison with Seven Other Human Populations

Fernández-Santander¹,

Kandil²,

Luna³

et al. 2002

Human Biology

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A south central Moroccan sample was analyzed for 20 nuclear DNA polymorphisms (restriction fragment length polymorphisms). The population was chosen on the basis of available information on its history, making it suitable for comparisons with data from other European populations. The markers analyzed have been studied previously in several human groups from different continents, and data on African and European samples have been compared to evaluate the genetic affinity of the studied sample with other populations, especially with two Spanish groups: Basques and Andalusians. Heterozygosity levels showed intermediate values between the African and European groups and higher than those found so far in an African group for the studied markers. Genetic distances closely matched geographical relationships through neighbor-joining tree and correspondence analysis, the Moroccans being closer to the European groups than the sub-Saharan Africans included in the analysis. Allele distributions revealed specific population associations with large weight of several alleles in the differentiation of some groups. Gene flow from sub-Saharan Africa appears to be relevant in understanding the differentiation of present Moroccan populations.

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“…A number of genetic studies have been published on Andalusian population based on blood group system polymorphisms [20], erythrocyte enzymes [21], leucocyte polymorphisms (HLA class II) [22,23], and DNA autosomal and uniparental markers [24][25][26][27][28][29][30]. These surveys show heterogeneous results on the genetic affinity between Andalusia and North Africa -neighbouring western populations specifically.…”

Section: Introductionmentioning

confidence: 99%