Genetic relationship between Escherichia coli strains isolated from the intestinal flora and those responsible for infectious diseases among patients hospitalized in intensive care units

Mereghetti, Laurent; Tayoro, J.; Watt, Stephen; Lanotte, Philippe; Loulergue, J.; Perrotin, D.; Quentin, Roland

doi:10.1053/jhin.2002.1259

Cited by 12 publications

(6 citation statements)

References 26 publications

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“…Differences in VF, O-group and phylogroup composition among commensal and extra-intestinal pathogenic strains have been often observed (e.g. Johnson et al 2004; Kudinha et al 2013; Clermont et al 2017; Mereghetti et al 2002; Kauffmann 1947) contrary to difference in clone diversity (Caugant et al 1983). Here, we explicitly quantify the difference in ST diversity (ST number, size and distribution) among commensal and extra-intestinal pathogenic strains.…”

Section: Discussionmentioning

confidence: 99%

The population genomics of increased virulence and antibiotic resistance in human commensal Escherichia coli over 30 years in France

Marin

Clermont

Royer

et al. 2021

Preprint

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Escherichia coli is a commensal species of the lower intestine, but also a major pathogen causing intestinal and extra-intestinal infections. Most studies on genomic evolution of E. coli used isolates from infections, and/or focused on antibiotic resistance, but neglected the evolution of virulence. Here instead, we whole-genome sequenced a collection of 436 E. coli isolated from fecal samples of healthy adult volunteers in France between 1980 and 2010. These isolates were distributed among 159 sequence types (STs), the five most frequent being ST10 (15.6%), ST73 (5.5%) and ST95 (4.8%), ST69 (3.7%) and ST59 (3.7%), and 230 O:H serotypes. ST and serotype diversity increased over time. Comparison with 912 E. coli bacteremia isolates from similar region and time showed a greater diversity in commensal isolates. The O1, O2, O6 and O25-groups used in bioconjugate O-antigen vaccine were found in only 63% of the four main STs associated with a high risk of bacteremia (ST69, ST73, ST95 and ST131). In commensals, STs associated with a high risk of bacteremia increased in frequency. Both extra-intestinal virulence-associated genes and resistance to antibiotics increased in frequency. Evolution of virulence genes was driven by both clonal expansion of STs with more virulence genes, and increases in frequency within STs, whereas the evolution of resistance was dominated by increases in frequency within STs. This study provides a unique picture of the phylogenomic evolution of E. coli in its human commensal habitat over a 30-year period and suggests that the efficacy of O-antigen vaccines would be threatened by serotype replacement.

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Section: Discussionmentioning

confidence: 99%

The population genomics of increased virulence and antibiotic resistance in human commensal Escherichia coli over 30 years in France

Marin

Clermont

Royer

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Differences in VF, O-group and phylogroup composition among commensal and extra-intestinal pathogenic strains have been often observed (e.g. Johnson et al 2004;Kudinha et al 2013;Clermont et al 2017;Mereghetti et al 2002;Kauffmann 1947) contrary to difference in clone diversity (Caugant et al 1983). Here, we explicitly quantify the difference in ST diversity (ST number, size and distribution) among commensal and extra-intestinal pathogenic strains.…”

Section: The Phylogenetic Distribution Of E Coli Commensal Strainsmentioning

confidence: 99%

The Population Genomics of Increased Virulence and Antibiotic Resistance in Human Commensal Escherichia coli over 30 Years in France

Marin

Clermont

Royer

et al. 2022

Appl Environ Microbiol

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“…Infections caused by ExPEC strains account for serious morbidity and mortality in immune-compromised and in hospitalized patients (Mereghetti et al, 2002;Foxman and Brown, 2003;Bagshaw and Laupland, 2006). Unfortunately, due to extreme heterogeneity of ExPEC populations and their increased resistance to antimicrobials, efficient identification and subsequent eradication of potentially pathogenic resident strains in patients at high-risk groups are difficult (Foxman et al, 2000;Gaynes and Edwards, 2005).…”

Section: Article In Pressmentioning

confidence: 99%

Aspects of genome plasticity in pathogenic Escherichia coli

Bielaszewska

Dobrindt

Gartner

et al. 2007

International Journal of Medical Microbiology

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Genetic relationship between Escherichia coli strains isolated from the intestinal flora and those responsible for infectious diseases among patients hospitalized in intensive care units

Cited by 12 publications

References 26 publications

The population genomics of increased virulence and antibiotic resistance in human commensal Escherichia coli over 30 years in France

The population genomics of increased virulence and antibiotic resistance in human commensal Escherichia coli over 30 years in France

The Population Genomics of Increased Virulence and Antibiotic Resistance in Human Commensal Escherichia coli over 30 Years in France

Aspects of genome plasticity in pathogenic Escherichia coli

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