Genetic Regulation Mechanism of Cadmium Accumulation and Its Utilization in Rice Breeding

Chen, Guang; Du, Ruiying; Wang, Xu

doi:10.3390/ijms24021247

Cited by 13 publications

(8 citation statements)

References 96 publications

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“…However, there have been few studies on the breeding of rice varieties that accumulate low contents of As. The breeding of low cadmium rice provides a framework for breeding rice plants that accumulate low levels of As [ 242 ]. First, we propose to introduce the alleles for the low accumulation of As into excellent backbone parents through cross-breeding or to aggregate the alleles that control yield and resistance into varieties that accumulate low levels of As to obtain varieties of rice with high yields that are highly resistant to As.…”

Section: The Primary Strategies To Reduce the Accumulation Of As In Ricementioning

confidence: 99%

The Molecular Mechanism of the Response of Rice to Arsenic Stress and Effective Strategies to Reduce the Accumulation of Arsenic in Grain

Geng,

Lian,

Wang

et al. 2024

IJMS

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Rice (Oryza sativa L.) is the staple food for more than 50% of the world’s population. Owing to its growth characteristics, rice has more than 10-fold the ability to enrich the carcinogen arsenic (As) than other crops, which seriously affects world food security. The consumption of rice is one of the primary ways for humans to intake As, and it endangers human health. Effective measures to control As pollution need to be studied and promoted. Currently, there have been many studies on reducing the accumulation of As in rice. They are generally divided into agronomic practices and biotechnological approaches, but simultaneously, the problem of using the same measures to obtain the opposite results may be due to the different species of As or soil environments. There is a lack of systematic discussion on measures to reduce As in rice based on its mechanism of action. Therefore, an in-depth understanding of the molecular mechanism of the accumulation of As in rice could result in accurate measures to reduce the content of As based on local conditions. Different species of As have different toxicity and metabolic pathways. This review comprehensively summarizes and reviews the molecular mechanisms of toxicity, absorption, transport and redistribution of different species of As in rice in recent years, and the agronomic measures to effectively reduce the accumulation of As in rice and the genetic resources that can be used to breed for rice that only accumulates low levels of As. The goal of this review is to provide theoretical support for the prevention and control of As pollution in rice, facilitate the creation of new types of germplasm aiming to develop without arsenic accumulation or within an acceptable limit to prevent the health consequences associated with heavy metal As as described here.

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Section: The Primary Strategies To Reduce the Accumulation Of As In Ricementioning

confidence: 99%

The Molecular Mechanism of the Response of Rice to Arsenic Stress and Effective Strategies to Reduce the Accumulation of Arsenic in Grain

Geng,

Lian,

Wang

et al. 2024

IJMS

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“…As for modern MAS, the genes related to the Cd uptake and distribution are targets to manipulate for selecting and breeding low Cd accumulation cultivars. For instance, an irradiation-induced rice mutant with a mutated allele of OsNRAMP5 (A mPingA1 was transposed into a preferred insertion site [TTA] in an exon of OsNRAMP5) showed almost no Cd accumulation in the grain, which is registered as a new cultivar and used to breed other low-Cd cultivars in Japan. , Recently, Yu et al (2022) discovered the OsNRAMP5 gene is completely absent in two Indica rice accessions among1000 accessions, which exhibit very low Cd uptake in phenotypic experiments and further serve as valuable parental materials for breeding low-Cd hybrid rice. As previously mentioned, an old rice cultivar with a duplication of OsNramp5 would increases the Cd uptake into root cells .…”

Section: Molecular-assisted Breeding Of Cd-pscsmentioning

confidence: 99%

Molecular-Assisted Breeding of Cadmium Pollution-Safe Cultivars

Ni,

Mubeen,

Leng

et al. 2023

J. Agric. Food Chem.

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Cadmium (Cd) contamination in edible agricultural products, especially in crops intended for consumption, has raised worldwide concerns regarding food safety. Breeding of Cd pollution-safe cultivars (Cd-PSCs) is an effective solution to preventing the entry of Cd into the food chain from contaminated agricultural soil. Molecular-assisted breeding methods, based on molecular mechanisms for cultivar-dependent Cd accumulation and bioinformatic tools, have been developed to accelerate and facilitate the breeding of Cd-PSCs. This review summarizes the recent progress in the research of the low Cd accumulation traits of Cd-PSCs in different crops. Furthermore, the application of molecular-assisted breeding methods, including transgenic approaches, genome editing, marker-assisted selection, whole genome-wide association analysis, and transcriptome, has been highlighted to outline the breeding of Cd-PSCs by identifying critical genes and molecular biomarkers. This review provides a comprehensive overview of the development of Cd-PSCs and the potential future for breeding Cd-PSC using modern molecular technologies.

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“…OsHMA2 and OsHMA3 of the HMA family were identified as key genes involved in Cd translocation [49]. OsHMA3 further reduces Cd translocation to above ground by translocating Cd absorbed by the root system to the vesicles for storage, thereby reducing Cd content above ground as well as Cd accumulation in the grains of rice [50,51].…”

Section: Changes In Expression Of CD Transporter Genes In Rice In Res...mentioning

confidence: 99%

Cadmium Absorption in Various Genotypes of Rice under Cadmium Stress

Feng

Yang

et al. 2023

IJMS

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Cadmium (Cd) is a kind of heavy metal. Cadmium pollution in paddy fields will accumulate a large amount of cadmium in rice, which will affect the growth and development of rice. In addition, long-term consumption of rice contaminated with Cd can harm human health. In this study, four rice varieties with high Cd accumulation (S4699, TLY619, JHY1586, QLY155) and four varieties with low Cd accumulation (YY4949, CYJ-7, G8YXSM, MXZ-2) were screened through field experiments for two consecutive years (2021 and 2022) and differences in antioxidant enzyme systems and expression of genes in their organs were analyzed. The total Cd content showed as follows: indica rice > japonica rice, high-Cd-accumulation variety > low-Cd-accumulation variety, and the total Cd content of each organ of rice showed root > stem > leaf > grain. The results of the antioxidant enzyme system showed that the contents of malondialdehyde (MAD), reduced glutathione (GSH), oxidized glutathione (GSSH), and peroxidase (POD) were positively correlated with the total Cd content in rice, and superoxide dismutase (SOD) showed the opposite performance in the leaves. There was no correlation between catalase (CAT) and Cd content, but CAT content decreased in leaves and grains and increased in roots and stems with increasing fertility. Based on this study, RT-qPCR was used to further validate the expression of Cd-uptake-related genes in different rice varieties. It was found that high expression of OsHMA3, OsCCX2, OsNRAMP5, and OsHMA9 genes promoted Cd uptake and translocation in rice, especially in rice varieties with high Cd accumulation. The high expression of OslRT1, OsPCR1, and OsMTP1 genes hindered Cd uptake by rice plants, which was especially evident in low-accumulating Cd rice varieties. These results provide an important theoretical reference and scientific basis for our in-depth study and understanding of the mechanism of cadmium stress tolerance in rice.

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Genetic Regulation Mechanism of Cadmium Accumulation and Its Utilization in Rice Breeding

Cited by 13 publications

References 96 publications

The Molecular Mechanism of the Response of Rice to Arsenic Stress and Effective Strategies to Reduce the Accumulation of Arsenic in Grain

The Molecular Mechanism of the Response of Rice to Arsenic Stress and Effective Strategies to Reduce the Accumulation of Arsenic in Grain

Molecular-Assisted Breeding of Cadmium Pollution-Safe Cultivars

Cadmium Absorption in Various Genotypes of Rice under Cadmium Stress

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