The light guide plate (LGP) printing process is used to obtain the optimal optical brightness, which requires the optimization of the LGP printing process parameters. This study analyzed the optical brightness optimization parameter design. This study integrated the back-propagation neural network (BPN) and a revised genetic algorithm (GA) to identify the optimal experimental level combination of the optical brightness parameter design. The obtained optical brightness process capability C pk by the proposed method was 1.73, which was better than the process capability C pk of 1.65 obtained by using the Taguchi method.