Genetic profile for dopamine signaling predicts brain functional reactivity to repetitive transcranial magnetic stimulation

Hong, Haejin; Kim, Rye Young; Song, Yumi; Suh, Chaewon; Lee, Hyangwon; Lyoo, In Kyoon; Yoon, Sujung; Lim, Soo Mee; Lee, Suji

doi:10.1007/s00406-022-01436-2

Cited by 2 publications

(1 citation statement)

References 77 publications

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“…SNPs underlie differences in susceptibility to many diseases, including some inducing pain, and can modify pain thresholds especially when pain modulatory pathways are challenged (Vetterlein et al, 2023); it is, therefore, conceivable that they may contribute to the heterogeneity of response to rTMS. Since monoaminergic mechanisms modulate pain responses, and polymorphisms in dopamine‐related genes can change functional connectivity following rTMS (Hong et al, 2023), a number of authors assessed the influence of the dopamine (DRD2) and COMT gene polymorphisms on the rTMS analgesic effect. The homozygous DRD2 T/T genotype was found associated with a positive response to M1 rTMS in two studies gathering patients with orofacial ( n = 16) or central post‐stroke pain ( n = 17; Jääskeläinen et al, 2014; Ojala et al, 2022).…”

Section: Genotyping To Select Candidates?mentioning

confidence: 99%

Beyond trial‐and‐error: Individualizing therapeutic transcranial neuromodulation for chronic pain

Ciampi de Andrade,

García‐Larrea

2023

European Journal of Pain

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Background and ObjectiveRepetitive transcranial magnetic stimulation (rTMS) applied to the motor cortex provides supplementary relief for some individuals with chronic pain who are refractory to pharmacological treatment. As rTMS slowly enters treatment guidelines for pain relief, its starts to be confronted with challenges long known to pharmacological approaches: efficacy at the group‐level does not grant pain relief for a particular patient. In this review, we present and discuss a series of ongoing attempts to overcome this therapeutic challenge in a personalized medicine framework.Databases and Data TreatmentRelevant scientific publications published in main databases such as PubMed and EMBASE from inception until March 2023 were systematically assessed, as well as a wide number of studies dedicated to the exploration of the mechanistic grounds of rTMS analgesic effects in humans, primates and rodents.ResultsThe main strategies reported to personalize cortical neuromodulation are: (i) the use of rTMS to predict individual response to implanted motor cortex stimulation; (ii) modifications of motor cortex stimulation patterns; (iii) stimulation of extra‐motor targets; (iv) assessment of individual cortical networks and rhythms to personalize treatment; (v) deep sensory phenotyping; (vi) personalization of location, precision and intensity of motor rTMS. All approaches except (i) have so far low or moderate levels of evidence.ConclusionsAlthough current evidence for most strategies under study remains at best moderate, the multiple mechanisms set up by cortical stimulation are an advantage over single‐target ‘clean’ drugs, as they can influence multiple pathophysiologic paths and offer multiple possibilities of individualization.SignificanceNon‐invasive neuromodulation is on the verge of personalised medicine. Strategies ranging from integration of detailed clinical phenotyping into treatment design to advanced patient neurophysiological characterisation are being actively explored and creating a framework for actual individualisation of care.

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Section: Genotyping To Select Candidates?mentioning

confidence: 99%

Beyond trial‐and‐error: Individualizing therapeutic transcranial neuromodulation for chronic pain

Ciampi de Andrade,

García‐Larrea

2023

European Journal of Pain

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Anatomo-physiological basis and applied techniques of electrical neuromodulation in chronic pain

Guzzi,

Della Torre,

Bruni

et al. 2024

J Anesth Analg Crit Care

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Chronic pain, a complex and debilitating condition, poses a significant challenge to both patients and healthcare providers worldwide. Conventional pharmacological interventions often prove inadequate in delivering satisfactory relief while carrying the risks of addiction and adverse reactions. In recent years, electric neuromodulation emerged as a promising alternative in chronic pain management. This method entails the precise administration of electrical stimulation to specific nerves or regions within the central nervous system to regulate pain signals. Through mechanisms that include the alteration of neural activity and the release of endogenous pain-relieving substances, electric neuromodulation can effectively alleviate pain and improve patients' quality of life. Several modalities of electric neuromodulation, with a different grade of invasiveness, provide tailored strategies to tackle various forms and origins of chronic pain. Through an exploration of the anatomical and physiological pathways of chronic pain, encompassing neurotransmitter involvement, this narrative review offers insights into electrical therapies’ mechanisms of action, clinical utility, and future perspectives in chronic pain management.

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Genetic profile for dopamine signaling predicts brain functional reactivity to repetitive transcranial magnetic stimulation

Cited by 2 publications

References 77 publications

Beyond trial‐and‐error: Individualizing therapeutic transcranial neuromodulation for chronic pain

Beyond trial‐and‐error: Individualizing therapeutic transcranial neuromodulation for chronic pain

Anatomo-physiological basis and applied techniques of electrical neuromodulation in chronic pain

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