Genetic profile characterization and segregation analysis of 10 X-STRs in a sample from Santander, Colombia

Pico, Adriana Lucía; Castillo, A.; Vargas, Clara Inés; Amorim, António; Gusmão, Leonor

doi:10.1007/s00414-007-0215-1

Cited by 19 publications

(6 citation statements)

References 22 publications

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“…The allele 7 of GATA172D05 was reported in German, Korean, and Colombian population but is absent in the Pakistani population, consistent with the Italian population [4,[16][17][18][19]. The allele 10 of marker HPRTB was reported in German, Hungarian, Korean, African Americans, Hispanics, and Portuguese populations but were not observed in the Pakistani population [1,4,15,17]. Presence of new alleles was confirmed by sequencing the PCR products.…”

Section: Resultssupporting

confidence: 76%

Allele frequency distribution of 13 X-chromosomal STR loci in Pakistani population

2008

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Short tandem repeat (STR) markers are extensively being used for human identification as well as paternity and forensic case work. X-chromosome STR (X-STR) markers are a powerful complementary system especially in deficiency paternity testing. Many X-linked microsatellites have been evaluated but further studies are required to determine population specific statistics. Here, we report allele frequencies of 13 X-linked microsatellites (DXS8378, DXS9902, DXS6810, DXS7132, DXS981, DXS6793, DXS6801, DXS6789, GATA172D05, HPRTB, GATA31E08, DXS8377, and DXS7423) in the Pakistani population. Blood samples were collected from individuals representing all major ethnic groups of the Pakistan population. A total of 5-18 alleles were observed for each locus and altogether 109 alleles for all 13 X-STR loci. Heterozygosity in females ranged from 0.524 to 0.884. No significant deviation was observed from Hardy-Weinberg equilibrium for all 13 microsatellites. In addition, there was no evidence of linkage disequilibrium in any pairs of these markers. These results strongly suggest that the X-linked microsatellites described here can potentially serve as an extension to autosomal systems currently used in parentage analysis and forensic case work.

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Section: Resultssupporting

confidence: 76%

Allele frequency distribution of 13 X-chromosomal STR loci in Pakistani population

2008

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“…The p values of the 13 loci showed no significant differences (p>0.05). Among these data, two alleles of DXS8377 have not been reported previously [3,11,[16][17][18]. These two new alleles were sequenced for confirmation and the results are presented in Table 3.…”

Section: Resultsmentioning

confidence: 76%

Thirteen X-chromosomal short tandem repeat loci multiplex data from Taiwanese

Hwa

Chang²,

Lee

et al. 2009

Int J Legal Med

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Study results of variations in the X chromosome are useful tools in researching the genetic diversity of human populations and individual identification. We developed a 13 X chromosomal short tandem repeat (STR) multiplex system (DXS6807, DXS8378, DSX9902, DXS7132, DXS9898, DXS6809, DXS6789, DXS7424, DXS101, GATA172D05, HPRTB, DXS8377, DXS7423) amplified in one single polymerase chain reaction. DNA samples of 113 male and 108 female Taiwanese Han subjects were successfully analyzed using this 13 X-STR multiplex system. The distributions of allele frequencies were examined for independence. DXS8377, DXS101, DXS6789, and DXS6809 were found to be the most polymorphic markers in this study. High values of discrimination power and mean exclusion chance without significant evidence of association between these markers were obtained. In conclusion, this 13 X chromosomal STR multiplex system offers considerable forensic efficiency and may be useful in forensic identification casework.

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“…Recently, more and more X-STR loci have been reported for forensic purpose [2][3][4]. Some genetic polymorphisms of them have been conducted in a number of populations [5][6][7]. Although China is the largest multi-ethnic country in the world with a population of about 1.4 billion, there are few reports about both polymorphism and mutation rates of X-STR loci in Chinese populations.…”

Section: Introductionmentioning

confidence: 98%

Development of the nine X-STR loci typing system and genetic analysis in three nationality populations from China

Liu¹,

Lu²,

et al. 2010

Int J Legal Med

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This study is to develop a new multiplex polymerase chain reaction (PCR) system that simultaneously amplifies the nine X-chromosome short tandem repeats loci in the same PCR reaction, and to explore their polymorphism and mutation rate among three nationality populations from China. These loci included DXS6854, DXS9902, DXS6809, GATA172D05, HPRTB, DXS7423, DXS6807, DXS8378, and DXS8377. The samples of 890 (484 males and 406 females) unrelated individuals from Guangdong Han population, Xinjiang Uigur, and Inner-Mongolia Mongol were successfully analyzed using this multiplex system. The allele frequencies and mutation rates of the nine loci were investigated, and the comparison of allele frequency distribution among different populations was performed. There were 87 alleles for all the loci, and six to 18 alleles for each locus observed by our new multiplex PCR system. Polymorphism information content was 0.4998-0.9101, and power of discrimination in females was 0.6518-0.9846. Five cases with mutation of above loci were detected in 5,310 meioses. Pair-wise comparisons of allele frequencies distribution showed significant differences for most loci among different populations. Our results indicate that this multiplex system is very useful for identification analysis, and that the information about polymorphism and mutation rate is necessary for forensic application in three nationality populations from China.

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Genetic profile characterization and segregation analysis of 10 X-STRs in a sample from Santander, Colombia

Cited by 19 publications

References 22 publications

Allele frequency distribution of 13 X-chromosomal STR loci in Pakistani population

Allele frequency distribution of 13 X-chromosomal STR loci in Pakistani population

Thirteen X-chromosomal short tandem repeat loci multiplex data from Taiwanese

Development of the nine X-STR loci typing system and genetic analysis in three nationality populations from China

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