Genetic Problems and Congenital Malformations in 1987 ICSI Children

Bonduelle, M; Aytoz, Ayse; Wilikens, Ann; Buysse, Andrea; Assche, Elvire Van; Devroey, Paul; Steirteghem, André Van; Liebaers, Inge

doi:10.1007/978-1-4612-1522-6_26

Male Sterility and Motility Disorders 1999

DOI: 10.1007/978-1-4612-1522-6_26

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Genetic Problems and Congenital Malformations in 1987 ICSI Children

M Bonduelle¹,

Ayse Aytoz²,

Ann Wilikens³

et al.

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2004

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“…We do not know the reason for the higher rate of birth defects detected in the ART-twin group, especially the ICSI-twin group. Previous studies indicated that some chromosomal anomalies, including de-novo structural anomalies or sex chromosomal anomalies, were observed more frequently in infants conceived by ICSI (Bonduelle et al, 2002b;Van Steirteghem, 1998). Although we have not analyzed chromosomes except in clinically suspicious cases, such increase in chromosomal abnormalities, if present in this series of ICSI infants, may partly account for the higher incidence of birth defects observed in the ICSI group.…”

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confidence: 98%

The Risk of Birth Defects in Dichorionic Twins Conceived by Assisted Reproductive Technology

Kuwata

Matsubara²,

Ohkuchi

et al. 2004

Twin Res

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The purpose of this study was to examine whether dichorionic twins conceived by assisted reproductive technology (ART; intracytoplasmic sperm injection [ICSI], in vitro fertilization [IVF], gamete-intrafallopian tube transfer [GIFT]) have a higher risk of birth defects compared to dichorionic twins conceived naturally. We reviewed the medical records of 406 mothers with dichorionic twin pregnancies, who received continuous antenatal care from < or = 20 weeks of gestation and gave birth to infants after > or = 24 weeks of gestation in our institute. Birth defects were diagnosed at the time of hospital discharge according to the International Classification of Diseases, 10th Revision. Occurrence of birth defects was compared between twins conceived by ART and those conceived naturally using logistic regression analysis. Overall, 51 of 812 infants (51/812 = 6.2%) had birth defects. The incidence of birth defects in ART-conceived twins was significantly higher than that of naturally conceived twins with an odds ratio of 6.9 (95% confidence interval [CI] 2.1, 22.5), 3.7 (95% CI 1.2, 12.0), and 4.3 (95% CI 1.4, 14.3) for ICSI, IVF, and GIFT, respectively. The higher frequency of birth defects in ART-conceived twins was still significant after adjusting for higher maternal age in the ART group, with an adjusted odds ratio of 6.7 (95% CI 2.1, 21.9), 3.6 (95% CI 1.1, 11.5), and 3.7 (95% CI 1.2-11.8) for ICSI, IVF, and GIFT, respectively. Dichorionic twins conceived by ART, compared to dichorionic twins conceived naturally, had a much higher risk for birth defects diagnosed at hospital discharge.

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mentioning

confidence: 98%

The Risk of Birth Defects in Dichorionic Twins Conceived by Assisted Reproductive Technology

Kuwata

Matsubara²,

Ohkuchi

et al. 2004

Twin Res

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Genetic Problems and Congenital Malformations in 1987 ICSI Children

Cited by 1 publication

References 27 publications

The Risk of Birth Defects in Dichorionic Twins Conceived by Assisted Reproductive Technology

The Risk of Birth Defects in Dichorionic Twins Conceived by Assisted Reproductive Technology

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