Genetic predisposition toward suicidal ideation in patients with acute coronary syndrome

Abstract

The genetic predisposition toward suicidal ideation has been explored to identify subgroups at high risk and to prevent suicide. Acute coronary syndrome (ACS) is associated with an increased risk of suicide, but few studies have explored the genetic predisposition toward suicide in ACS populations. Therefore, this longitudinal study explored the genetic predisposition toward suicidal ideation in ACS patients. In total, of 969 patients within 2 weeks after ACS, 711 were followed at 1 year after ACS. Suicidal ideation was evaluated with the relevant items on the Montgomery–Åsberg Depression Rating Scale. Ten genetic polymorphisms associated with serotonergic systems, neurotrophic factors, carbon metabolism, and inflammatory cytokines were examined. Associations between genetic polymorphisms and suicidal ideation within 2 weeks and 1 year of ACS were investigated using logistic regression models. The 5-HTTLPR s allele was significantly associated with suicidal ideation within 2 weeks of ACS after adjusting for covariates and after the Bonferroni correction. TNF-α –308G/A, IL-1β –511C/T, and IL-1β + 3953C/T were significantly associated with suicidal ideation within 2 weeks after ACS, but these associations did not reach significance after the Bonferroni correction in unadjusted analyses and after adjusting for covariance. However, no significant association between genetic polymorphisms and suicidal ideation was found at 1 year. Genetic predisposition, 5-HTTLPR s allele in particular, may confer susceptibility to suicidal ideation in ACS patients during the acute phase of ACS.

Length Polymorphisms in the Angiotensin I-Converting Enzyme Gene and the Serotonin-Transporter-Linked Polymorphic Region Constitute a Risk Haplotype for Depression in Patients with Coronary Artery Disease

“…In relation to stressful life events, individuals with one or two copies of the short allele exhibited more depressive symptoms and suicidality than subjects homozygous for the long allele. This observation was confirmed by Kang et al who demonstrated that the short allele may cause a genetic predisposition toward suicidal ideation in patients 2 weeks after an acute coronary syndrome (Kang et al 2017). While a meta-analysis found no evidence of a strong interaction between stress and the 5-HTTLPR genotype contributing to the development of depression (Culverhouse et al 2018), one study demonstrated effects of environmental stress and gender on associations among depressive symptoms and the 5-HTTLPR genotype (Brummett et al 2008a).…”

Dorsolateral and ventrolateral prefrontal cortex structural changes relative to suicidal ideation in patients with depression

“…stress and frustration in life) (Aaltonen et al, 2016;Zhang et al, 2016;Buckner et al, 2017). From a biological perspective, abnormalities in the serotonergic (5-hydroxytryptamine, 5-HT) system (Picouto et al, 2015), dysregulation of the hypothalamicpituitary-adrenal axis (Ghaziuddin et al, 2014), and a genetic contribution (Kang et al, 2017) to the risk of suicide have been found. Based on neuroimaging perspective, the present study observed that the left DLPFC GMV reductions as a biological factor may play a role in suicidal ideation in depression.…”

Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin

“…Some studies report different results such as an association of the lower expressing serotonin transporter S allele or S/S genotype of 5-HTTLPR polymorphism with extreme criminal behavior in Chinese male prisoners 76 and violent behavior in adult German criminal offenders with history of childhood ADHD 77 . Other studies also reported association of S allele or S/S genotype with antisocial alcoholism 78 , concussion history and personality traits in rugby players 79 , suicidal ideation in acute coronary syndrome patients 80 , higher impulsivity, hostility and neuroticism in anxiety phenotype 81 , hyperactivity-impulsivity in children moderated by peer problems earlier in childhood 82 and increased exposure to life stressors moderated by ADHD symptoms early in life 83 . Some meta-analyses also describe association of low expression allele/genotype of 5-HTTLPR polymorphism with anti-social behavior 84 , violent suicide attempts 85 and bipolar disorder 86 .…”