Genetic predisposition to periodontitis in children and young adults

Hodge, Penny; Michalowicz, Bryan S.

doi:10.1034/j.1600-0757.2001.2260106.x

Cited by 65 publications

(50 citation statements)

References 186 publications

(275 reference statements)

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“…34,35 Moreover, although AP is comparatively rare in the general population, studies of this disorder may reveal genetic variants which may also influence the onset, severity and progression of adult periodontitis. 36 In contrast to genetic associations in chronic periodontitis, several reports on AP indicate that the composite IL-1 genotype is not associated with this form of periodontal disease.…”

Section: Discussionmentioning

confidence: 99%

“…18 Recently, some comprehensive and detailed reviews have presented convincing evidence for heritable components of both susceptibility and progression (or severity) of periodontal diseases. [19][20][21][22][23] Many studies have focused on the potential role of several cytokines involved in the inflammatory response, among which some of the most investigated are the IL-1a, IL-1b and IL-1Ra, [24][25][26][27][28] genes which are all located on the long arm of chromosome 2 (region 2q13-14).…”

Section: Introductionmentioning

confidence: 99%

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Linkage disequilibrium analysis of case–control data: an application to generalized aggressive periodontitis

et al. 2004

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Several studies have shown a role for the involvement of interleukin (IL)-1 gene cluster polymorphisms in the risk of periodontal diseases. In the present study, we tested polymorphisms, derived from genes of the IL-1 cluster, for association with generalized aggressive periodontitis (GAP) through both allelic association and by constructing a linkage disequilibrium (LD) map of the 2q13-14 disease candidate region. The IL-1RN (VNTR) genotype distribution observed was significantly different in GAP and control subjects (P ¼ 0.019). We also observed some evidence for an association between GAP and the IL-1B þ 3953 polymorphism (P ¼ 0.039). The pattern of association in the region, represented as an LD map, identifies a recombination hot area between the IL-1B þ 3953 and IL-1B À511 polymorphisms. Multilocus modelling of association with disease gives a location for the peak association at the IL-1B þ 3953 marker, although support for the peak is not significant. Haplotype analysis identifies a IL-1B þ 3953 -IL-1B À511 haplotype as having the lowest P-value in the region. Recognition of the presence of a recombination hot area between the IL-1B þ 3953 and IL-1B À511 polymorphisms will have an important bearing on future efforts to develop higher resolution SNP analysis in this region for both this and other diseases for which this cluster is implicated.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Linkage disequilibrium analysis of case–control data: an application to generalized aggressive periodontitis

et al. 2004

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“…The underlying mechanisms causing these pathological changes are still unclear. Strong evidence exists that different genes may play a role in the predisposition to and in the progression of periodontal diseases (4). A number of genetic deficiencies or genetic variations in the host's tissue makeup, such as epithelial and fibroblast defects, may contribute to genetic susceptibility to aggressive periodontitis (5).…”

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confidence: 99%

Transforming Growth Factor Beta 1 and Vascular Endothelial Growth Factor Levels in the Pathogenesis of Periodontal Disease

et al. 2013

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Periodontal disease is characterized by inflammation and bone loss. The balance between inflammatory mediators and their counter-regulatory molecules may be fundamental for determining the outcome of immune pathology of periodontal disease. Cytokines play crucial roles in the maintenance of tissue homeostasis, a process which requires a delicate balance between anabolic and catabolic activities. In particular, two families of growth factors-such as transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor (VEGF) are thought to play important roles in modulating the proliferation and/or migration of structural cells involved in inflammation and regulation of immune responses. The aim of this work was to analyze gingival samples and periodontal tissue specimens collected from thirty-eight patients with chronic periodontal disease and from forty healthy individuals, in order to detect the expression and distribution of TGF-β1 and VEGF between the two groups. TGF-β1 and VEGF expression levels were detected using immunohistochemical analysis and computer-assisted morphometric analysis. The findings presented here suggest that biomarker such as TGF-β1 and VEGF have an important regulating role in the orchestration of the immune response, which in turn influence the outcome of disease establishment and evolution.

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“…There has been increasing evidence indicating that genes play a role in determining the susceptibility to and progression of periodontitis. 27,28 For instance, a clustering of aggressive periodontitis strongly suggests a genetic component of the disease.…”

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confidence: 99%

An Update on Novel Non‐Invasive Approaches for Periodontal Diagnosis

Xiang

Sowa

Iacopino

et al. 2010

Journal of Periodontology

102

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READ THESE TERMS AND CONDITIONS CAREFULLY BEFORE USING THIS WEBSITE.Access and use of this website and the material on it are subject to the Terms and Conditions set forth at http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/jsp/nparc_cp.jsp?lang=en An Update on Novel Non-Invasive Approaches for Periodontal DiagnosisXiang, Xiaoming; Sowa, Michael G.; Iacopino , Anthony M.; Maev, Roman G.; Hewko, Mark D.; Man, Angela; Liu, Kan-Zhi Abstract For decades there has been an ongoing search for clinically acceptable methods for the accurate, non-invasive diagnosis and prognosis of periodontitis. There are several well-known inherent drawbacks with current clinical procedures. The purpose of this review is to summarize some of the newly emerging diagnostic approaches, namely, infrared spectroscopy, optical coherence tomography (OCT), and ultrasound. The history and attractive features of these new approaches are briefly illustrated, and the interesting and significant inventions related to dental applications are discussed. The particularly attractive aspects for the dental community are that some of these methods are totally non-invasive, do not impose any discomforts to the patients during the procedure, and require no tissue to be extracted. For instance, multiple inflammatory indices withdrawn from near infrared spectra have the potential to identify early signs of inflammation leading to tissue breakdown. Morphologically, some other non-invasive imaging modalities, such as OCT and ultrasound, could be employed to accurately measure probing depths and assess the status of periodontal attachment, the front-line of disease progression. Given that these methods reflect a completely different assessment of periodontal inflammation, if clinically validated, these methods could either replace traditional clinical examinations for the diagnosis of periodontitis or at least serve as attractive complementary diagnostic tools. However, the potential of these techniques should be interpreted more cautiously given the multifactorial character of periodontal disease. In addition to these novel tools in the field of periodontal inflammatory diseases, other alternative modalities like microbiologic and genetic approaches are only briefly mentioned in this review because they have been thoroughly discussed in other comprehensive reviews.Periodontitis is an endemic infectious disease of the tissues surrounding the teeth occurring in 50% of the population and may result in significant debilitation for about half of these persons. 1As the leading cause of edentulism, periodontitis may also have important implications for systemic health including an increased risk for cardiovascular disease and low birth weight/preterm delivery.2 According to a report by the World Health Organization, 3 severe periodontitis leading to tooth loss was found in 5% to 15% of most populations worldwide. Therefore, it is considered one of the most important global oral health burdens.Periodontitis is a multifactorial disease with microbial dental plaque as the in...

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Genetic predisposition to periodontitis in children and young adults

Cited by 65 publications

References 186 publications

Linkage disequilibrium analysis of case–control data: an application to generalized aggressive periodontitis

Linkage disequilibrium analysis of case–control data: an application to generalized aggressive periodontitis

Transforming Growth Factor Beta 1 and Vascular Endothelial Growth Factor Levels in the Pathogenesis of Periodontal Disease

An Update on Novel Non‐Invasive Approaches for Periodontal Diagnosis

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