Genetic Predisposition to Periodontitis and Risk of Migraine: A Two-Sample Mendelian Randomization Study

Abstract

Introduction: Previous observational studies have associated periodontitis (PD) with migraine; however, the results are inconclusive and the causality of the association between PD and migraine remains unclear. This two-sample Mendelian randomization (MR) study was performed to explore the bi-directional causal relationship between PD and migraine. Methods: To investigate the relationship between PD (17,353 cases; 28,210 controls) and migraine (1072 cases; 360,122 controls), we used genetic tools from the largest available genome-wide association study of European descent. Inverse variance-weighted (IVW) and a series of sensitivity analyses were used to explore the association between migraine and

A Mendelian Randomisation Analysis Reveals No Relationship Between Periodontitis and Coronary Atherosclerosis

“… 24 Given the urgency to investigate the potential causal link between periodontitis and coronary atherosclerosis. Scholars have employed MR analysis to study the relationship between periodontitis and multiple non-oral diseases, 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 including arthritis, hypertension, psoriasis, Parkinson's disease, inflammatory bowel disease (IBD), etc. However, most studies have not provided strong supporting a significant causal relationship between the periodontitis and these diseases, suggesting that periodontitis may be a comorbid condition or that other shared disease mechanisms are yet to be explored.…”