Genetic predisposition to gestational glucose metabolism and gestational diabetes mellitus risk in a Chinese population

Abstract

Background Genome‐wide association studies (GWAS) have identified several genetic variants affecting gestational glucose metabolism. However, information regarding their known associations with gestational diabetes mellitus (GDM) risk remains scarce. Methods This study examined the associations of 12 gestational glucose metabolism‐related variants with GDM risk in a Chinese population (964 GDM cases, 1021 controls). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression analysis. Results Rs10830963 in melatonin receptor 1B (MTNR1B) was found to be associated with an increased risk of GDM, after adjusting for age, prepregnancy body mass index, parity, abnormal pregnancy history, and family history of diabetes (OR 1.20; 95% CI 1.05‐1.36; P = 0.007). Compared with women with a family history of diabetes, there was a significant association of rs7936247 with GDM risk among pregnant women without a family history of diabetes (OR 1.20; 95% CI 1.04‐1.38; P = 0.014; Pheterogeneity = 0.035). Further functional annotations showed that rs10830963 and rs7936247 fell in the functional elements of human pancreatic islets. Genotype‐phenotype associations indicated that the variants may contribute to GDM risk by affecting the expression of nearby or distant genes. Conclusions The findings of this study suggest that rs10830963 and rs7936247 may be markers for susceptibility to GDM in a Chinese population. Additional studies are warranted to validate our findings and clarify the underlying mechanism.

Need to establish a new adolescent suicide prevention programme in South Korea

“…50 Although several suicide prevention activities or strategies have been implemented, strategies proven effective in reducing suicide rates, such as early intervention for youth with mental health disorders, are often not available. Only through a comprehensive and in-depth investigation on the genetic architecture, biomarkers and comorbidities, can the high-risk population at pre-diagnostic or prodromal or asymptomatic stages be targeted, [51][52][53][54][55] and clinical patients can be classified 56 and be treated individually. 50 57 Currently, Korea has implemented a suicide report system with the information mainly provided by the teachers who have a suicidal student.…”

Gestational Diabetes Mellitus: The Genetic Susceptibility Behind the Disease

“…Gestational diabetes mellitus (GDM), a type of pregnancy-specific glucose intolerance or hyperglycemia, is one of the most common metabolic disorders in pregnant women [1]. GDM has emerged as an urgent public health concern, with more than a 30 % increase in prevalence over the past few decades [2]. According to the International Diabetes Federation, the global prevalence of gestational hyperglycemia is 16.9 %, including all cases of diabetes in pregnancy (i. e., known and previously undiagnosed diabetes) and gestational diabetes [3].…”

“…Furthermore, in a 5-10-year perspective, it was estimated that approximately 50 % of the women diagnosed with GDM will develop T2DM [5]. Thus, it is of paramount clinical value to identify potential risk factors for GDM, and to provide evidence for early-prevention measures [2].…”

“…Although multiple risk factors for GDM have been identified, the mechanism of action underlying these risk factors remains arcane. However, an increasing number of reports indicate that GDM carries a strong genetic susceptibility [2]. We searched the PubMed, Embase and Web of Science databases for association studies identifying the susceptibility gene of GDM.…”

Acculturation and endocrine disrupting chemical-associated personal care product use among US-based foreign-born Chinese women of reproductive age

“…Despite having a lower body mass index, Asian ethnicity has independently been associated with higher insulin resistance during pregnancy [ 6 ]. Previous studies have focused on the contributions of dietary [ 7 ] and genetic [ 8 ] factors to GDM in Chinese women. However, differences in reproductive and birth outcomes between foreign- and US-born women demonstrate the need to investigate explanations beyond genetic components for racial/ethnic differences [ 9 – 11 ].…”