Genetic predisposition to gastro-oesophageal cancer

Lao‐Sirieix, Pierre; Caldas, Carlos; Fitzgerald, Rebecca C.

doi:10.1016/j.gde.2010.03.002

Cited by 54 publications

(44 citation statements)

References 75 publications

(72 reference statements)

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“…Four reviews (35)(36)(37)(38) were also excluded. In addition, 3 studies (22,24,39) were excluded because of their unavailable or incomplete data.…”

Section: Results Of Literature Search and Selectionmentioning

confidence: 99%

Prostate Stem Cell Antigen Polymorphisms and Susceptibility to Gastric Cancer: A Systematic Review and Meta-analysis

Zhang¹,

Li²,

Wang³

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Many studies have reported that prostate stem cell antigen (PSCA) polymorphisms (rs2294008 and/or 2976392) are significantly associated with gastric cancer (GC) risk, although the published results are inconsistent. We conducted a systematic review and meta-analysis for relevant literatures to quantitatively evaluate the relationship between PSCA polymorphisms and GC susceptibility.Methods: Extensive searches were conducted in three databases up to November 1, 2011. ORs and 95% CIs were used to assess the strength of the associations. The data were further stratified by ethnicity, histopathology, subsite, and study design. All of the associations were evaluated with dominant model and recessive model, respectively. Heterogeneity and publication bias were also assessed by Q test, I

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“…Four reviews (35)(36)(37)(38) were also excluded. In addition, 3 studies (22,24,39) were excluded because of their unavailable or incomplete data.…”

Section: Results Of Literature Search and Selectionmentioning

confidence: 99%

Prostate Stem Cell Antigen Polymorphisms and Susceptibility to Gastric Cancer: A Systematic Review and Meta-analysis

Zhang¹,

Li²,

Wang³

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…The effect of the rs2294008 C > T polymorphism was greater in diffuse than in intestinaltype gastric cancer, consistent with previous reports. The genetic susceptibility factors may contribute more to diffuse-type gastric cancer development compared to intestinal-type gastric cancer (Lao-Sirieix et al, 2010), so genetic variations appear to be associated with an increased risk for diffuse-type gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of gastric cancer is regulated by multi-factors, including oncogene tumor suppressor gene in abnormal activation/ inactivation, immune changes, and etc. With the depth of new technologies, many efforts have been invested in identifying sources of genetic susceptibility to cancer in the last few decades (Dong et al, 2008;Lao-Sirieix et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Association of the PSCA rs2294008 C＞T Polymorphism with Gastric Cancer Risk: Evidence from a Meta-Analysis

Yao¹,

Gu²,

Gu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: Multiple studies have reported associations between the PSCA rs2294008 C > T polymorphism and GC, but susceptibility has proven inconsistent. Therefore, we estimates the relationship between the rs2294008 C > T polymorphism and GC by meta-analysis. Methods: PubMed, Embase and Web of Science databases were searched and nine independent case-control studies were included in this meta-analysis. Crude ORs with 95% CIs were extracted according to the Mantal-Haenszel method and pooled to assess the strength of the association. Results: We observed that the PSCA rs2294008 C > T polymorphism was significantly correlated with GC risk when all studies were pooled into the meta-analysis. Further subgroup analysis showed the polymorphism to be linked with diffuse and noncardia GC in the allele contrast model, homozygote codominant model, dominant model, and recessive model. However, no connection was apparent for intestinal and cardia GC. In the stratified analysis by ethnicity, significant associations were observed in Asians for the recessive model. Interestingly, the relationship was particularly significant in the Chinese population. Conclusions: Our findings suggest that the PSCA rs2294008 C > T polymorphism is a risk factor for GC, especially in diffuse and noncardia GC and in Chinese.

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“…Gastric cancer is one of the most common types of tumors worldwide, and it ranks as the second leading cause of cancer-related deaths (Lao-Sirieix et al, 2010). Its incidence shows wide geographical variation, and almost two-thirds of all gastric cancer cases occur in developing countries, with 42% of them occurring in China alone.…”

Section: Introductionmentioning

confidence: 99%

Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Epidemiological studies have indicated that folate metabolism is correlated with increased risk of gastric cancer. Since methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, in this study, we examined whether polymorphisms and haplotypes of MTHFR are correlated with the risk of gastric cancer. The polymorphisms MTHFR C677T and MTHFR A1298C were genotyped by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis in 285 patients and 570 healthy controls. Association analyses based on binary logistic regression were conducted to determine the odds ratio (OR) and its 95% confidence interval (95%CI) for each genotype. The MTHFR 677TT genotype was significantly related with a reduced risk of gastric cancer (OR = 0.60, 95%CI = 0.39-0.92) compared to the CC genotype. Similarly, the MTHFR 1298CC genotype was significantly MTHFR and risk of gastric cancer associated with a decreased risk of cancer (OR = 0.52, 95%CI = 0.32-0.81). Haplotype analysis showed that the TC haplotype was associated with a reduced risk of gastric cancer compared to the most common haplotype, CA (OR = 0.28, 95%CI = 0.12-0.60). Our results suggest that the MTHFR C677T and MTHFR A1298C polymorphisms are related to gastric cancer susceptibility in the Chinese population.

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Genetic predisposition to gastro-oesophageal cancer

Cited by 54 publications

References 75 publications

Prostate Stem Cell Antigen Polymorphisms and Susceptibility to Gastric Cancer: A Systematic Review and Meta-analysis

Prostate Stem Cell Antigen Polymorphisms and Susceptibility to Gastric Cancer: A Systematic Review and Meta-analysis

Association of the PSCA rs2294008 C＞T Polymorphism with Gastric Cancer Risk: Evidence from a Meta-Analysis

Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer

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