Genetic Predisposition Scores Associate with Muscular Strength, Size, and Trainability

Thomaes, Tom; Thomis, Martine; Onkelinx, Steven; Goetschalckx, Kaatje; Fagard, Robert; Lambrechts, Diether; Vanhees, Luc

doi:10.1249/mss.0b013e31828983f7

Cited by 26 publications

(44 citation statements)

References 40 publications

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“…The insignificance of age might be due to close ages of participants and limited training period. Although the findings of Thomaes' study 20 which did not find a significant relation between GPS and isometric knee extension strength, ANCOVA analysis in our study showed that GPS was positively related to baseline PTIM60. This might be attributed to a larger SNP pool in the present study.…”

Section: Discussioncontrasting

confidence: 99%

“…Sibling and twin studies estimated the heritability of muscle strength and muscle mass, indicating that the individual genetic makeup can exert an influence on the development of muscle mass and strength 18 . This indicates that the response variability resulting from exercise might be related to inherited characteristics 19,20 .…”

Section: Introductionmentioning

confidence: 97%

“…Through the usage of GPS, heritability studies have been able to show the role genetic factors plays in the changes of muscular phenotypes after exercise intervention. Recent studies have been made on elite athletes 24,25 and patients with coronary artery disease 19,20 . To the best of our knowledge, no studies have been performed combining muscle-related genes with GPS to explain baseline muscular phenotypes and exercise-induced muscular changes in a healthy elderly population.…”

Section: Introductionmentioning

confidence: 99%

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Genetic predisposition score predicts the increases of knee strength and muscle mass after one-year exercise in healthy elderly

Roie

Bogaerts

et al. 2018

Experimental Gerontology

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This study aims to identify a genetic predisposition score from a set of candidate gene variants that predicts the response to a one-year exercise intervention. 200 participants (aged 60-83 years) were randomly assigned to a fitness (FIT), whole-body vibration (WBV) and control group. Participants in the exercise (FIT and WBV) groups performed a one-year intervention program. Whole-body skeletal muscle mass (SMM) and isometric knee extension strength (PT) were measured before and after the intervention. A set of 170 muscle-related single nucleotide polymorphisms (SNPs) were genotyped. Stepwise regression analysis was applied to select significantly contributing SNPs for baseline and relative change parameters. A data-driven genetic predisposition score (GPS) was calculated by adding up predisposing alleles for each of the phenotypes. GPS was calculated based on 4 to 8 SNPs which were significantly related to the corresponding phenotypes. These SNPs belong to genes that are involved in myoblast differentiation, muscle and bone growth, myofiber contraction, cytokines and DNA methylation. GPS was related to baseline PT and relative changes of SMM and PT in the exercise groups, explaining the variance of the corresponding parameter by 3.2%, 14% and 27%, respectively. Adding one increasing allele in the GPS increased baseline PTIM by 4.73 Nm, and exercise-induced relative changes of SMM and PT by 1.78% and 3.86% respectively. The identified genetic predisposition scores were positively related to baseline knee extension strength and muscle adaptations to exercise in healthy elderly. These findings provide supportive genetic explanations for high and low responders in exercise-induced muscle adaptations.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Genetic predisposition score predicts the increases of knee strength and muscle mass after one-year exercise in healthy elderly

Roie

Bogaerts

et al. 2018

Experimental Gerontology

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“…For instance, muscle maximal shortening velocity ( V max ) is positively correlated with fascicle length . Although no direct associations between TTN and fascicle length have been reported, the aforementioned C>T transition within the TTN gene has been identified as contributing significantly to a genetic predisposition for maximal isokinetic strength at 180°·s −1 but not 60°·s −1 , which could indirectly demonstrate that variability in V max is influenced by genotype‐dependent differences in fascicle length. Furthermore, enhanced efficiency of stretch‐shortening contractions can be expected in individuals possessing shorter muscle fascicles due to the lower metabolic cost of producing a given force.…”

Section: Introductionmentioning

confidence: 99%

TTN genotype is associated with fascicle length and marathon running performance

Stebbings

Williams

Herbert

et al. 2017

Scandinavian Med Sci Sports

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Titin provides a molecular blueprint for muscle sarcomere assembly, and sarcomere length can vary according to titin isoform expression. If variations in sarcomere length influence muscle fascicle length, this may provide an advantage for running performance. Thus, the aim of this study was to investigate whether the titin (TTN) rs10497520 polymorphism was associated with muscle fascicle length in recreationally active men (RA; n=137) and marathon personal best time in male marathon runners (MR; n=141). Fascicle length of the vastus lateralis was assessed in vivo using B-mode ultrasonography at 50% of muscle length in RA. All participants provided either a whole blood, saliva or buccal cell sample, from which DNA was isolated and genotyped using real-time polymerase chain reaction. Vastus lateralis fascicle length was 10.4% longer in CC homozygotes, those carrying two copies of the C-allele, than CT heterozygotes (P=.003) in RA. In the absence of any TT homozygotes, reflective of the low T-allele frequency within Caucasian populations, it is unclear whether fascicle length for this group would have been smaller still. No differences in genotype frequency between the RA and MR groups were observed (P=.500), although within the MR group, the T-allele carriers demonstrated marathon personal best times 2 minutes 25 seconds faster than CC homozygotes (P=.020). These results suggest that the T-allele at rs10497520 in the TTN gene is associated with shorter skeletal muscle fascicle length and conveys an advantage for marathon running performance in habitually trained men.

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“…Studies rely on these resources to obtain data related to the response to interventions related to exercise [18, 19]. Indeed, the possibility to identify genes and their allelic states that could determine which individuals would perform better in some sports disciplines brought the concept of genetic scores based on a personal genetic profile [20]. …”

Section: Commentmentioning

confidence: 99%

Letter to the editor: A genetic-based algorithm for personalized resistance training

Monnerat

Paulucio²,

Neto

et al. 2017

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Genetic Predisposition Scores Associate with Muscular Strength, Size, and Trainability

Abstract: GPS for muscular phenotypes showed to be associated with baseline KES, muscle diameter, and the response to training in cardiac rehabilitation patients.

Cited by 26 publications

References 40 publications

Genetic predisposition score predicts the increases of knee strength and muscle mass after one-year exercise in healthy elderly

Genetic predisposition score predicts the increases of knee strength and muscle mass after one-year exercise in healthy elderly

TTN genotype is associated with fascicle length and marathon running performance

Letter to the editor: A genetic-based algorithm for personalized resistance training

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