Genetic predisposition of SNPs in miRNA-149 (rs2292832) and FOXE1 (rs3758249) in thyroid Cancer

Khan, Rashida; Shaheen, Hamayun; Mansoor, Qaisar; Abbasi, Samina Asghar; Fatima, Shazia; Ammar, Ayesha; Baig, Ruqia Mehmood

doi:10.1007/s11033-021-06795-y

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…However, the studies carried out by Wei et al predicted that the rs2910164 is playing a key role in transferring the benign nodules into PTCs [ 11 ]. It was found that miRNAs have many targets and have the potential to fine-tune gene expression and different physiological and pathological processes which initiate the cancer [ 12 ]. This study aimed to understand the possible association of this SNP with PTC in the Pakistani population.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Rare Alleles of miRNA-146a (rs2910164) and miRNA-34b/c (rs4938723) as a Prognostic Marker in Thyroid Cancer in Pakistani Population

et al. 2022

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Papillary thyroid cancer (PTC) patients with age and gender-matched controls were recruited for the present study. DNA extraction, genotyping of rs2910164 and rs4938723 was carried out by ARMS-PCR. Statistical analyses were carried out using SPSS software (version 20). Results: The odds ratio for risk allele C of rs2910164 for patients and controls was 23.0168 (3.0321–174.7208) with a p-value of <0.0001, showing that the frequency of the major allele G was lower in patients while the frequency of minor allele C was higher in patients. Similarly, the odds ratio for risk allele C of rs4938723 was 1.8621 (1.0321–3.3596) with a p-value of <0.03788 showing significant association with the development of thyroid cancer. Conclusions: The study highlights the significant association of miRNAs SNPs as one of the genetic risk factor for PTC. It was concluded that miRNA-146a (rs2910164) showed higher frequency of minor allele C in patients. Similarly in miRNA-34b/c gene SNP rs4938723 was observed to have a strong association with the development of thyroid cancer as the frequency of rare allele C was higher in patients.

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Section: Introductionmentioning

confidence: 99%

Analysis of Rare Alleles of miRNA-146a (rs2910164) and miRNA-34b/c (rs4938723) as a Prognostic Marker in Thyroid Cancer in Pakistani Population

et al. 2022

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“…The miRNAs are small, non-coding RNAs that regulate gene expression, and their dysfunction alters the expression of oncogenic or tumor-suppressor target genes [ 97 ]. Recently, Khan et al demonstrated a strong association between miRNA-149 ( MIR149 ) gene SNP rs2292832 and thyroid cancer, specifically the mutation T > C ( p = 0.0004) [ 98 ]. Furthermore, Khan et al observed that miRNA-34b/c ( MIR34B ) gene SNP rs4938723 had a strong association with thyroid cancer occurrence [ 99 ].…”

Section: Single Nucleotide Polymorphism and Thyroid Cancermentioning

confidence: 99%

The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 Update

Tiucă

Paşcanu

2023

Biomedicines

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Thyroid cancer is the most common endocrine malignancy, with an increasing trend in the past decades. It has a variety of different histological subtypes, the most frequent one being differentiated thyroid cancer, which refers to papillary carcinoma, the most common histological type, followed by follicular carcinoma. Associations between genetic polymorphisms and thyroid cancer have been investigated over the years and are an intriguing topic for the scientific world. To date, the results of associations of single nucleotide polymorphisms, the most common genetic variations in the genome, with thyroid cancer have been inconsistent, but many promising results could potentially influence future research toward developing new targeted therapies and new prognostic biomarkers, thus consolidating a more personalized management for these patients. This review focuses on emphasizing the existing literature data regarding genetic polymorphisms investigated for their potential association with differentiated thyroid cancer and highlights the opportunity of using genetic variations as biomarkers of diagnosis and prognosis for thyroid cancer patients.

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“…PCR-restriction fragment length polymorphism (PCR-RFLP) has been used to identify SNPs in RNA. The method rely on PCR followed by enzymatic digestion to detect allelic variations by gel separation [5][6][7]. The major limitation of this method is the need to identify and apply only SNPs that overlap restriction enzyme recognition sites.…”

Section: Introductionmentioning

confidence: 99%

Mutations in microRNA-128-2-3p identified with amplification-free hybridization assay

Slott,

Krüger-Jensen,

Ferreira da Silva

et al. 2023

PLoS ONE

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We describe a quantitative detection method for mutated microRNA in human plasma samples. Specific oligonucleotides designed from a Peyrard-Bishop model allowed accurate prediction of target:probe recognition affinity and specificity. Our amplification-free tandem bead-based hybridization assay had limit of detection of 2.2 pM. Thereby, the assay allowed identification of single-nucleotide polymorphism mismatch profiles in clinically relevant microRNA-128-2-3p, showing terminal mutations that correlate positively with inflammatory colitis and colorectal cancer.

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Genetic predisposition of SNPs in miRNA-149 (rs2292832) and FOXE1 (rs3758249) in thyroid Cancer

Cited by 4 publications

References 33 publications

Analysis of Rare Alleles of miRNA-146a (rs2910164) and miRNA-34b/c (rs4938723) as a Prognostic Marker in Thyroid Cancer in Pakistani Population

Analysis of Rare Alleles of miRNA-146a (rs2910164) and miRNA-34b/c (rs4938723) as a Prognostic Marker in Thyroid Cancer in Pakistani Population

The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 Update

Mutations in microRNA-128-2-3p identified with amplification-free hybridization assay

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