Genetic predisposition of RSV infection-related respiratory morbidity in preterm infants

Drysdale, Simon B.; Prendergast, Michael; Alcazar-Paris, Mireia; Wilson, Theresa; Smith, M. A.; Zuckerman, Mark; Broughton, Simon; Rafferty, Gerrard F.; Johnston, Sebastian L.; Hodemaekers, Hennie M.; Janssen, Riny; Bont, Louis; Greenough, Anne

doi:10.1007/s00431-014-2263-0

Cited by 40 publications

(40 citation statements)

References 33 publications

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“…Previous genetic studies have demonstrated a significant association between the inherited polymorphisms in several immunological and surfactant protein genes and the incidence of severe viral infection and level of infection-related morbidity among preterm infants [50,51]. Also, pre-existing impairments in lung function have also been attributed to increased susceptibility to severe viral infection and infection-related morbidity among preterm infants, particularly during early life [52–54].…”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

“…Although it is possible that the immature lungs in preterm infants might be particularly susceptible to long-term damage following severe RSV-related respiratory illness during early life [66,73], RSV infection during such a critical period of lung growth and development can also result in chronic alterations and remodelling of the developing airways independent of pre-existing neonatal factors [50,72]. The underlying mechanisms through which RSV could promote the development of suboptimal lung health and function later in life are yet to be fully elucidated.…”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

“…Several mechanistic pathways have been hypothesised to describe the potential role of severe RSV-related respiratory illnesses in the pathogenesis of asthma and wheezing disorders later in life, including persistent activation of atypical immune responses and alterations to the structure and function of the developing airway [50,72,74]. Mouse models have also demonstrated the ability of RSV to induce and maintain prolonged inflammatory responses leading to significant damage to the airway epithelium, as well as chronic airway remodelling and persistent airway hyperresponsiveness following the initial infection [75–77].…”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

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The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased burden of viral respiratory infections is likely to have long term implications for lung health and function in individuals born preterm, particularly those with bronchopulmonary dysplasia. Several hypotheses have been put forward to explain the association between early life viral respiratory infection and development of suboptimal lung health and function later in life following preterm birth. Although preterm infants with diminished lung function, particularly small airways, might be particularly susceptible to asthma and wheezing disorders following viral infection, there is evidence that respiratory viruses can activate number of inflammatory and airway re-modelling pathways. Therefore, the aim of this review is to highlight the perinatal and early life risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants during early life and to understand how respiratory viral infection may influence the development of abnormal lung health and function later in life.

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Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

See 1 more Smart Citation

The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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“…61,97 Preterm infants with poor initial IFNγ responses may therefore have more severe symptoms upon LRI viral infections in infancy and beyond. Finally, a genetic susceptibility to morbidity after RSV infection may also contribute to severity of disease after LRI, 98 and it is possible that such associations exist with HMPV.…”

Section: Hmpv In Preterm Infantsmentioning

confidence: 99%

Human metapneumovirus in the preterm neonate: current perspectives

Maitre

Williams

2016

RRN

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Premature birth (<37 weeks gestation) occurs in ~11% of all births in the US. These infants are at risk of chronic lung disease and respiratory conditions, including bronchopulmonary dysplasia. Respiratory viruses are important causes of acute respiratory illness (ARI) in preterm infants, leading to rehospitalization, increased health care burden, and long-term morbidity. Human metapneumovirus (HMPV) is a paramyxovirus discovered in 2001 that is related to respiratory syncytial virus. Epidemiologic studies show that HMPV is a leading cause of ARI in children and adults worldwide. Prematurity is a major risk factor for severe HMPV disease, requiring hospitalization. Moreover, limited data suggest that HMPV infection during infancy is associated with asthma and recurrent wheezing, which are common long-term pulmonary complication of prematurity. HMPV causes nosocomial outbreaks of ARI in hospitals and long-term care facilities, although there are few studies of the prevalence of HMPV in neonatal intensive care unit populations. HMPV is a common and important virus in premature infants, and caregivers for preterm infants should consider this virus in patients with acute respiratory symptoms.

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“…To assess whether some premature infants are genetically predisposed to clinical bronchiolitis, DRYSDALE et al [90] followed infants discharged from a single maternity unit, and tested nasopharyngeal aspirates whenever infants had a lower respiratory tract infection. When these data were linked to 11 single nucleotide polymorphisms, an association was found between an single nucleotide polymorphisms in ADAM33 and increased risk of developing an RSV-associated lower respiratory tract infection.…”

Section: Viral Infectionsmentioning

confidence: 99%