Genetic Predisposition, Fruit Intake and Incident Stroke: A Prospective Chinese Cohort Study

Abstract

The aim of this study was to evaluate the association between fruit intake and stroke risk considering the genetic predisposition. We used data from 34,871 participants from the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR project) from 2007 to 2020. A polygenic risk score comprising 534 genetic variants associated with stroke and its related factors was constructed to categorize individuals into low, intermediate, and high genetic risk groups. The associations of genetic and fruit intake with incident stroke were assessed by the Cox proportional hazard regression. We documented 2586 incident strokes during a median follow-up of 11.2 years. Compared with fruit intake < 200 g/week, similar relative risk reductions in stroke with adherence to fruit intake > 100 g/day across the genetic risk categories were observed (28–32%), but the absolute risk reductions were relatively larger in the highest genetic risk group (p for trend = 0.03). In comparison to those with a fruit intake < 200 g/week, those with a fruit intake >100 g/day in the low, intermediate, and high genetic risk groups had an average of 1.45 (95% CI, 0.61–2.31), 2.12 (1.63–2.59), and 2.19 (1.13–3.22) additional stroke-free years at aged 35, respectively. Our findings suggest that individuals with a high genetic risk could gain more absolute risk reductions and stroke-free years than those with a low genetic risk from increasing fruit intake for the stroke primary prevention.

Fruit and vegetable intake and the risk of arterial hypertension in China: A prospective cohort study

“…In line with these results, our study found that a long‐term higher TFV intake was associated with a lower risk of incident hypertension. Recently, results from the same cohorts indicated that an increased TFV intake was associated with a decreased risk of stroke, cardiovascular disease (CVD), and all‐cause mortality 27,28 . These results are strongly supported by our findings that the incidence of hypertension, an important risk factor for incident CVD, decreased with increasing TFV intake.…”

“…(CVD), and all-cause mortality. 27,28 These results are strongly supported by our findings that the incidence of hypertension, an important risk factor for incident CVD, decreased with increasing TFV intake.…”

SERPINE1 mRNA Binding Protein 1 Is Associated with Ischemic Stroke Risk: A Comprehensive Molecular–Genetic and Bioinformatics Analysis of SERBP1 SNPs

“…Nonetheless, the most important finding is that four SNPs showed an association with APTT in the presence of a risk factor such as low consumption of fresh vegetables and fruits, suggesting that the prothrombotic effects of SERBP1 risk alleles are significantly modified by this risk factor. Low consumption of fresh vegetables and fruits primarily correlates with oxidative stress [44,45], the role of which in the risk of IS and IS-related phenotypes has been demonstrated in a substantial number of studies [6,[46][47][48][49][50]. Plant-based diets usually contain phenolic acids, flavonoids, and carotenoids, which have strong antioxidant properties and therefore eliminate an excess of active oxygen from the body and protect cells from damage, thereby reducing the risk of cardiovascular diseases [51].…”

Dietary Patterns, Physical Activity, and Lifestyle in the Onset, Prevention, and Management of Noncommunicable Diseases

“…Wang et al [9] conducted a prospective cohort study that investigated the association between fruit intake and stroke with consideration for genetic disposition in a cohort of almost 35,000 individuals from the project Prediction for Atherosclerotic Cardiovascular Disease Risk in China (CHINA-PAR). This study reported that a greater amount of fruit consumption was associated with a lower risk of stroke (28-32%), whereby individuals who had a higher genetic risk of stroke may gain more benefits in terms of more stroke-free years and absolute risk reduction.…”