Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (<scp>MMP</scp>‐2, <scp>MMP</scp>‐9, <scp>MMP</scp>‐12) and their inhibitor <scp>TIMP</scp>‐2

Slonková, Veronika; Vašků, Anna; Vašků, Vladimı́r

doi:10.1111/jdv.14447

Cited by 17 publications

(13 citation statements)

References 28 publications

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“…Although a number of genes have been implicated, 89 to date, no causal association has been proved. 90 GWASs in >400 000 individuals established 12 candidate loci for varicose veins in individuals with European ancestry, highlighting the SNPs CASZ1 , PIEZO1 , PPP3R1 , EBF1 , STIM2 , HFE , GATA2 , NFATC2 , and SOX9 .…”

Section: Venous Thromboembolism (Deep Vein Thrombosis and Pulmonary E...mentioning

confidence: 99%

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2022

Circulation

3,064

2,336

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Background: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). Methods: The American Heart Association, through its Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update. The 2022 Statistical Update is the product of a full year’s worth of effort by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. This year’s edition includes data on the monitoring and benefits of cardiovascular health in the population and an enhanced focus on social determinants of health, adverse pregnancy outcomes, vascular contributions to brain health, and the global burden of cardiovascular disease and healthy life expectancy. Results: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. Conclusions: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

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Section: Venous Thromboembolism (Deep Vein Thrombosis and Pulmonary E...mentioning

confidence: 99%

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2022

Circulation

3,064

2,336

View full text Add to dashboard Cite

show abstract

“…More recently, it has been shown (7,18) that specific polymorphisms in the MMP-9 and TIMP-2 genes potentially increase the risk of developing varicose veins in patients. Vein remodeling and associated gene expression were also studied, but the results did not correlate with the development and severity of PTS [5,12]. However, their preliminary data showed an increase in MMP-9 expression and a decrease in Toll-like receptor 9 expression in acute deep vein thrombosis.…”

Section: Research Results and Discussionmentioning

confidence: 99%

“…Both MMP and TIMP regulate extracellular matrix homeostasis. MMPs are involved in the degradation of extracellular matrix components, while TIMPs affect vascular remodeling by causing changes in venous elasticity [6,12]. MMPs can also influence biologically active molecules present on the cell surface through G protein-coupled receptors (GPCRs) and regulate the cellular environment [13].…”

Section: The Actualitymentioning

confidence: 99%

The Role of Genetic Polymorphism in the Pathogenesis of Chronic Venous Insufficiency

E.A.¹

2022

ijcsrr

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Chronic venous diseases (CVD), including varicose veins, are among the most common diseases in developed countries in Europe and the United States and affect one third to one half of the population, especially women. Among many achievements in the knowledge of the pathogenesis of achievements, it should be noted the identification of the role of matrix metalloproteinases (MMPs) as important mediators of the degenerative process associated with the onset and progression of venous insufficiency. The study included 98 patients aged 20 to 78 years with chronic venous insufficiency, including, in accordance with the CEAP classification, 45 patients with moderate CVI (class C3–C4) and 53 patients with severe CVI (class C5–C6). The results obtained in the course of the study reliably indicate the presence of an association between the carriage of the Arg allele and the Gln/Arg and Arg/Arg genotypes of the Gln279Arg polymorphism in the MMP9 gene with the risk of developing complicated forms of CVI.

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“…We must emphasize that after the visit of a Vascular Specialist the prescription of venoactive drugs and graduated compression stockings rose 3-fold. This clearly shows the importance of being taken in charge by a vascular specialist (6, [26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Delphi case: Sharing of clinical experiences for improvement in the treatment of chronic venous disease

Camporese

Aloi²,

Santoliquido³

2022

Front. Cardiovasc. Med.

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Chronic venous disease (CVD) is a common condition with major health consequences that is associated with poor long-term prognosis, significant socioeconomic impact, disabling symptoms, and reduced quality of life. To provide a novel evidence-based approach in the management of CVD, a consensus process (“Delphi Case”) following a first Delphi Consensus was conceived. With a real-life fashion analysis, a steering committee formed by 3 expert leaders on chronic venous disease drove a panel of 77 expert Italian angiologists/vascular surgeons along a collegial discussion, integrating data coming from the guidelines recommendations of different Vascular Scientific Societies with the consensus agreement statements gathered from the first Delphi Consensus, and with data coming from the discussion of few statements in which there was disagreement. From July 15 to October 16, 2020, demographic, anamnestic, objective, and therapeutic data coming from a total of 2,275 patients were collected by the experts panel using a predefined case report form. The results of this second consensus provided a real-life picture of CVD management in the Italian population and clearly showed that a tailored therapeutic approach together with an appropriate lifestyle (e.g., diet, physical activity, weight loss) must be considered as the milestones for the CVD-related signs and symptoms clinical improvement in daily clinical practice. An evaluation of the adherence and of the efficacy of the prescribed pharmacological and compressive treatment in a medium-long term follow-up of the study population has been planned as the last step of this course and will be object of a future final publication.

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Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP‐2, MMP‐9, MMP‐12) and their inhibitor TIMP‐2

Abstract: Studying these polymorphisms can contribute to better identification of patients at higher risk of developing CVD, while providing the most appropriate prevention and treatment strategies for limiting the progression and complications of CVD.

Cited by 17 publications

References 28 publications

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

The Role of Genetic Polymorphism in the Pathogenesis of Chronic Venous Insufficiency

Delphi case: Sharing of clinical experiences for improvement in the treatment of chronic venous disease

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