Genetic predisposition and its impact on natural history of idiopathic acute and acute recurrent pancreatitis in children

Poddar, Ujjal; Yachha, Surender Kumar; Mathias, Amrita; Choudhuri, Gourdas

doi:10.1016/j.dld.2015.04.012

Cited by 30 publications

(15 citation statements)

References 33 publications

(50 reference statements)

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“…Poddar et al . [8] studied mutations in PRSS1 gene, SPINK1 gene, and CFTR gene. Thirty-three percent children with AP, 45.4% with acute recurrent, and 54.4% with CP of unknown origin were genetically predisposed.…”

Section: Discussionmentioning

confidence: 99%

Pediatric pancreatitis: Outcomes and current understanding

Vepakomma

2020

J Indian Assoc Pediatr Surg

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Aim:The aim of this study was to analyze the clinical spectrum of pediatric pancreatitis and review current literature with regard to concepts of disease and management approaches.Materials and Methods:This is a retrospective analysis of pancreatitis patients admitted to a tertiary referral pediatric surgical unit from March 2013 to September 2018.Results:There were 106 patients from 1 year to 18 years with median age group between 11 and 15 years and equal gender distribution. Sixty-two children had acute pancreatitis (AP), with 13 of them having recurrent episodes. Forty-four patients had chronic pancreatitis (CP). Definite etiology was found in 11 AP patients. All patients had radiological changes. All AP patients were treated symptomatically except those with correctable underlying etiology. Sixteen with CP required intervention in the form of endoscopic retrograde cholangiopancreatography sphincterotomy/stenting or surgery. There were two mortalities. One with acute necrotizing pancreatitis and one CP girl due to the complication of diabetes mellitus, unrelated to episode of pancreatitis. All others are well at the last follow-up.Conclusion:Pediatric pancreatitis is a disease with a wide spectrum, but management can be standardized. Newer studies reveal that certain genetic mutations make children more susceptible to pancreatitis. Increasing incidence must prompt us to evaluate further so as to better equip ourselves to managing this disease entity in all its forms and evolve preventive strategies.

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Section: Discussionmentioning

confidence: 99%

Pediatric pancreatitis: Outcomes and current understanding

Vepakomma

2020

J Indian Assoc Pediatr Surg

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“…Several pediatric series have described the high prevalence of genetic mutations in IAP (1)(2)(3)(4)(5), the most common involving PRSS1, CFTR and SPINK1 genes. A B…”

Section: Discussionmentioning

confidence: 99%

Genetics in idiopathic pancreatitis and acute recurrent pancreatitis

Martínez-Barona

Ribes-Koninckx

2017

Rev Esp Enferm Dig

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“…Poddar U и соавт. [21] изучали мутации в генах PRSS1, SPINK1 и CFTR. У 33% детей с острым п анкреатитом, у 45,4% с рецидивирующим и у 54,4% с хроническим панкреатитом были обнаружены генетические изменения.…”

Section: этиология и патогенезunclassified

Chronic pancreatitis in children: between gastroenterologist and surgeon

Кулевич

Разумовский

Smirnov

et al. 2020

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The pancreas is an organ that plays a key role in the digestive process, preparing food ingredients such as proteins, fats and carbohydrates for adequate absorption in the small intestine. Today, a wide range of pathological conditions is known in which the tissue of the pancreas is affected and its functions are lost. The literature review examined various diseases that phenotypically manifest as pancreatitis, as well as various diagnostic and therapeutic strategies.

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Genetic predisposition and its impact on natural history of idiopathic acute and acute recurrent pancreatitis in children

Cited by 30 publications

References 33 publications

Pediatric pancreatitis: Outcomes and current understanding

Pediatric pancreatitis: Outcomes and current understanding

Genetics in idiopathic pancreatitis and acute recurrent pancreatitis

Chronic pancreatitis in children: between gastroenterologist and surgeon

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