Genetic population structure of two African-Ecuadorian communities of Esmeraldas

Martínez-Labarga, C; Rickards, Olga; Scacchi, R.; Corbo, Rosa Maria; Biondi, G.; Peña, José A.; Vieira, Christophe; Guevara, Angel; Santurino, M.S. Mesa; Stefano, G. F. De

doi:10.1002/(sici)1096-8644(199906)109:2<159::aid-ajpa2>3.0.co;2-4

Cited by 17 publications

(9 citation statements)

References 35 publications

(47 reference statements)

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“…The genotypic frequencies were significantly different among the three groups for all the STR except for the HUMHPRTB (p= To characterize further the genetic structure of the Cuban population, the F-statistics were estimated by analysis of variance. The Fst value obtained (1.4%) was well in agreement with values reported for other populations of the world (Martínez-Labarga et al 1999). The estimated value of F is for the Cuban groups was not statistically different from zero.…”

Section: Resultssupporting

confidence: 89%

Genetic structure of a Cuban population based on nine short tandem repeat loci

Carpio

Peña²,

Santiesteban³

et al. 2005

Int J Legal Med

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Cuba is a multiethnic and multiracial society. Here we describe the genetic variation of a sample of the Cuban population, which include the three most common racial groups, Caucasians, Negroids and Mestizos, by means of a set of nine microsatellites (HUMTH01, HUMTPOX, HUMCFS1PO, HUMVWA, HUMFESFPS, HUMF13A, HUMF13B, HUMLPL and HUMHPRTB). The analysis presented here indicates that these STR loci are highly informative for forensic purposes. The genetic data on the major racial groups is in good agreement with current demographic tendencies and with historic events that took place during the formation of the Cuban population.

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Section: Resultssupporting

confidence: 89%

Genetic structure of a Cuban population based on nine short tandem repeat loci

Carpio

Peña²,

Santiesteban³

et al. 2005

Int J Legal Med

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“…New World populations of African ancestry have been of great anthropological interest (Da Silva et al, 1999;Martinez-Labarga et al, 1999). Afro-Caribbean human groups have received attention in part because of the interaction of natural selection and gene flow in shaping their population structure.…”

Section: Discussionmentioning

confidence: 99%

Ethnicity, gene flow, and population subdivision in Lim�n, Costa Rica

Madrigal

Ware

Miller

et al. 2001

Am. J. Phys. Anthropol.

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In this paper we examine the effects of ethnicity on the gene flow between two groups living in Limón, Costa Rica. Our main interest is to determine if ethnicity has acted as a barrier to the exchange of genes, and if the groups have remained distinct genetically. We report the admixture estimates, F(st) values, and inbreeding coefficients of the two samples. The data consist of blood samples and surnames obtained from 375 individuals. The subjects' two surnames were analyzed to determine the ethnicity of their parents (individuals carry their father's and mother's first surnames). We used the formula of Crow and Mange ([1965] Eugen Q 12:199-203) to compute F(t), F(n), and F(r) with the surnames. Admixture estimates were computed for both groups using the computer program ADMIX.PAS kindly provided by Jeffrey Long. The estimates for the Hispanic-Limonense group are M1 = 0.5866 European, M2 = 0.3383 Amerindian, and M3 = 0.0751 African ancestry. For the Afro-Limonense group, the admixture estimates indicate M1 = 0.1047 European, M2 = 0.1357 Amerindian, and M3 = 0.7595 African ancestry. The F(st) values are F(st) = 0.00558 for the Hispanic group and F(st) = 0.05137 for the Afro-Limonense group. These F(st) values indicate that the Afro-Limonense group has experienced more genetic drift than has the other group, possibly as a result of its long history of isolation in Costa Rica. Indeed, when plotted along a scaled eigenvector R matrix of Caribbean gene frequencies, the two Limonense groups did not cluster with each other. Thus we conclude that the two ethnic groups have remained distinct breeding populations.

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“…The newly genotyped population samples included (Table ): 95 north Africans from Morocco (Baassi et al, ) and 110 from Libya (Galgani et al, ); 56 Oromo from Asela, Oromia Region, central Ethiopia (Messina et al, ); 148 donors from two Ecuadorian communities of African ancestry living in the Esmeraldas province: 100 along Rio Cayapas and 48 in Viche village (Martínez‐Labarga et al, ; Rickards et al, ); 52 samples from China; 179 Ecuadorian Native Americans: 99 Cayapa Indians (Rickards, Martínez‐Labarga, Lum, De Stefano, & Cann, ) and 80 Tsáchila Indians (Babalini et al, ); 86 individuals from the Ladakh region of northern India; 1,204 Europeans (74 individuals from Albania, 100 Spaniards sampled in Vera and Bejar valleys, Sierra de Gredos, central Spain [Varano et al, ]; 1,030 Italians from different geographical regions [Supporting Information Table S1]), and 203 individuals of European ancestry living in Busselton, Western Australia.…”

Section: Methodsmentioning

confidence: 99%

Concerted variation of the 3′ regulatory region of Ig heavy chain and Gm haplotypes across human continental populations

Frezza

Martínez-Labarga

Giambra³

et al. 2020

American J Phys Anthropol

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Objectives The 3′ regulatory region of the immunoglobulin heavy chain gene (IGH) includes the HS1.2 enhancer displaying length polymorphism with four known variants. The goal of the research was to provide an overview of this variability and of its evolutionary significance across human populations. Materials and Methods We compiled published and original data on HS1.2 polymorphism in 3,100 subjects from 26 human populations. Moreover, we imputed the haplotypic arrangement of the HS1.2 region in the 1000 Genomes Project (1KGP). In this dataset, imputation could also be obtained for the G1m‐G3m allotype by virtue of the precise correspondence between serological types and amino acid (and DNA) substitutions in IGHG1 and IGHG3. Results HS1.2 variant frequencies displayed similar patterns of continental partitioning as those reported in the literature for the physically neighboring IGHG1‐IGHG3 system. The 1KGP data revealed that linkage disequilibrium (LD) can explain the spread of joint HS1.2‐IGHG1‐IGHG3 associations across continents and within continental populations, with stronger LD out of Africa and the features of an evolutionarily stable genomic block with differential expression in lymphoblastoid cell lines. Discussion Strong population structuring involves at least the entire 70 kb genomic region here considered, due to the tight LD which maintained HS1.2, IGHG1, and IGHG3 in nonrandom arrangements. This might be key to better understand the evolutionary path of the entire genomic region driven by immune response capabilities, during the formation of continental gene pools.

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Genetic population structure of two African-Ecuadorian communities of Esmeraldas

Cited by 17 publications

References 35 publications

Genetic structure of a Cuban population based on nine short tandem repeat loci

Genetic structure of a Cuban population based on nine short tandem repeat loci

Ethnicity, gene flow, and population subdivision in Lim�n, Costa Rica

Concerted variation of the 3′ regulatory region of Ig heavy chain and Gm haplotypes across human continental populations

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