Genetic polymorphisms of XRCC1 (at codons 194 and 399) in Shiraz population (Fars province, southern Iran)

Mohamadynejad, Parisa; Saadat, Mostafa

doi:10.1007/s11033-007-9138-7

Cited by 38 publications

(14 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 Standard (Dynacom Co, Ltd. Kanagawa, Japan). The closed physical proximity of the polymorphisms at codons 194 and 399 of XRCC1 place them in linkage disequilibrium (D 0 = 0.839, P \ 0.001), confirming our previous reports from Iranian population [9,15]. Comparisons of SRB between combination genotypes of XRCC1 showed that only combination genotype of ''Arg/Trp Arg/Arg'' (at codons 194 and 399, respectively) had higher male offspring (OR = 2.19; 95% CI = 1.…”

Section: To the Editorsupporting

confidence: 89%

Association between polymorphisms of XRCC1 and offspring sex ratio at births in families of female breast cancer patients

Saadat

2009

Breast Cancer Res Treat

Self Cite

View full text Add to dashboard Cite

Section: To the Editorsupporting

confidence: 89%

Association between polymorphisms of XRCC1 and offspring sex ratio at births in families of female breast cancer patients

Saadat

2009

Breast Cancer Res Treat

Self Cite

View full text Add to dashboard Cite

“…The closed physical proximity of the polymorphisms at codons 194 and 399 of XRCC1 should place them in linkage disequilibrium. Based on several studies, the polymorphisms of Arg194Trp and Arg399Gln showed linkage disequilibrium [39,46]. In all studies Arg194Trp and Arg399Gln polymorphisms showed linkage disequilibrium, except the study of Mitra et al [37] from India.…”

Section: Resultsmentioning

confidence: 98%

Haplotype analysis of XRCC1 (at codons 194 and 399) and susceptibility to breast cancer, a meta-analysis of the literatures

Saadat

2010

Breast Cancer Res Treat

Self Cite

View full text Add to dashboard Cite

To clarify the association between XRCC1 haplotypes and susceptibility to breast cancer, a meta-analysis of case-control studies were conducted. Eligible studies were identified by searching several databases for relevant reports published before March 2010. In total, 10 studies were included in the present meta-analysis. XRCC1 haplotypes for Arg194Trp and Arg399Gln polymorphisms were included in the analysis. The association was measured using random-effect model or fixed-effect model odds ratio (OR) combined with 95% confidence intervals (CIs) according to the between studies' heterogeneity. Large between-study heterogeneity was observed (Q = 25.587, df = 9, P < 0.001). The meta-analysis showed a borderline increased risk of breast cancer associated with the Arg194-Gln399 haplotype versus the Arg194-Arg399 haplotype (OR = 1.07, 95% CI: 1.01-1.14). There was no significant association between XRCC1 haplotypes and risk of breast cancer among Caucasoid subjects. In the next step, studies were classified according to geographical locations. Studies reported form Western populations did not show heterogeneity, and the Arg194-Gln399 haplotype was not associated with risk of breast cancer in comparison with the Arg194-Arg399 haplotype (OR = 1.02, 95% CI: 0.95-1.09). Among studies reported form Asian countries, significant heterogeneity was observed. After excluding of one study which did not show linkage disequilibrium, heterogeneity between studies decreased and haplotype Arg194-Gln399 revealed significant association with increased risk of breast cancer compared with haplotype Arg194-Arg399 (OR = 1.26, 95% CI: 1.04-1.50). There was no significant association between Trp194-Arg399 haplotype and risk of breast cancer, neither in Western nor Asian countries. The present meta-analysis has indicated that the Arg194-Gln399 haplotype of XRCC1 might be a risk factor for breast cancer in Asian countries.

show abstract

“…XRCC1 gene is mapped to human chromosome 19q13.2-13.3 (Mohrenweiser et al, 1989;Thompson et al, 1989) and consists of 17 exons (Wood et al, 2001). It encodes a protein of 633 amino acids (Mohamadynejad and Saadat, 2008) that functions in base excision repair (BER) (Caldecott et al, 1996) and in single-strand breaks (SSB) of damaged bases caused by endogenous and exogenous oxidants (Skjelbred et al, 2006). Proteins that associated to XRCC1 in facilitating the BER and SSB repair processes are polymerase beta, DNA ligase III and poly (ADP-ribose) polymerase (PARP) (Caldecott et al, 1996;Wood et al, 2001;Horton et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Variant Alleles in XRCC1 Arg194Trp and Arg399Gln Polymorphisms Increase Risk of Gastrointestinal Cancer in Sabah, North Borneo

Halim¹,

Chong²,

Goh³

et al. 2016

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: The XRCC1 protein facilitates various DNA repair pathways; single-nucleotide polymorphisms (SNPs) in this gene are associated with a risk of gastrointestinal cancer (GIC) with inconsistent results, but no data have been previously reported for the Sabah, North Borneo, population. We accordingly investigated the XRCC1 Arg194Trp and Arg399Gln SNPs in terms of GIC risk in Sabah. Materials and Methods: We performed genotyping for both SNPs for 250 GIC patients and 572 healthy volunteers using a polymerase chain reactionrestriction fragment length polymorphism approach. We validated heterozygosity and homozygosity for both SNPs using direct sequencing. Results: The presence of a variant 194Trp allele in the Arg194Trp SNP was significantly associated with a higher risk of GIC, especially with gastric and colorectal cancers. We additionally found that the variant 399Gln allele in Arg399Gln SNP was associated with a greater risk of developing gastric cancer. Our combined analysis revealed that inheritance of variant alleles in both SNPs increased the GIC risk in Sabah population. Based on our etiological analysis, we found that subjects ≥50 years and males who carrying the variant 194Trp allele, and Bajau subjects carrying the 399Gln allele had a significantly increased risk of GIC. Conclusions: Our findings suggest that inheritance of variant alleles in XRCC1 Arg194Trp and Arg399Gln SNPs may act as biomarkers for the early detection of GIC, especially for gastric and colorectal cancers in the Sabah population.

show abstract

Genetic polymorphisms of XRCC1 (at codons 194 and 399) in Shiraz population (Fars province, southern Iran)

Abstract: The present results indicated that the allelic frequencies in Iranian populations showed intermediate frequencies in comparison with European and other Asian countries.

Cited by 38 publications

References 16 publications

Association between polymorphisms of XRCC1 and offspring sex ratio at births in families of female breast cancer patients

Association between polymorphisms of XRCC1 and offspring sex ratio at births in families of female breast cancer patients

Haplotype analysis of XRCC1 (at codons 194 and 399) and susceptibility to breast cancer, a meta-analysis of the literatures

Variant Alleles in XRCC1 Arg194Trp and Arg399Gln Polymorphisms Increase Risk of Gastrointestinal Cancer in Sabah, North Borneo

Contact Info

Product

Resources

About