Genetic polymorphisms of vascular endothelial growth factor (VEGF) associated with gastric cancer recurrence after curative resection with adjuvant chemotherapy

Abstract

Background The relationship between polymorphisms in vascular endothelial growth factor (VEGF) and gastric cancer is still inconclusive. We investigated whether there is an association between VEGF genetic polymorphisms and risk of gastric cancer, and evaluated the recurrence of advanced gastric cancer after curative resection with adjuvant chemotherapy according to VEGF genetic polymorphisms. Methods The association of functional single nucleotide polymorphisms (SNPs) of the VEGF gene (+936C > T, − 634G > C, − 2578C > A, + 1612G > A) were evaluated. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. A total of 151 patients with gastric cancer were enrolled, and the control group consisted of 413 individuals with esophago-gastroduodenoscopy who were randomly selected through health screening. All of the enrolled patients had curative resections with completion of adjuvant capecitabine and oxaliplatin combination chemotherapy and the initial metastatic cases were excluded. During the regular follow-up protocol, the episodes of the recurrence were documented and the specific genotype and allelic frequencies were evaluated. Results As for the cancer risk, there were no significant differences in specific genotypes and allelic frequencies. The mean follow-up period was 28.82 ± 30.92 (12 ~ 72) months and the recurrence rate was 28.3%. In the patients carrying the 936-C allele, the recurrence rate of gastric cancer was high ( P = 0.02). Disease-free interval was significantly different between the patients carrying the 936-CC and 936-CT/TT genotype ( P = 0.02). Conclusions VEGF 936-C allele is associated with poor prognosis, but not risk of gastric cancer. In the patients carrying the 936-C allele, more potent adjuvant treatment would be considered.

Association of GAB2 with Quality of Life and Negative Emotions in Patients with Gastric Cancer after Postoperative Comprehensive Care

“…Patients received postoperative adjuvant combined chemotherapy and comprehensive care after chemotherapy [ 22 ]. The postoperative chemotherapy regimen was as follows: the patient was given a 3-week chemotherapy [ 23 ]. All patients had sufficient water and were administered standard preventive drugs to decrease toxicity.…”

Effects of VEGF Gene Polymorphisms on BEV Responsiveness in a Sample of Iraqi Colorectal Cancers Using HRM - PCR

“…Although VEGF has been targeted by BEV, the polymorphisms at the promoter region of VAGFA gene may cause accumulation of its product and lead to angiogenesis and subsequently may fundamentally impact the helpful adequacy of BEV chemotherapy. 17,18 Conflict of Interest: None Funding: Self Ethical Clearance: Not required…”

Impact of Angiogenesis- and Hypoxia-Associated Polymorphisms on Tumor Recurrence in Patients with Hepatocellular Carcinoma Undergoing Surgical Resection

“…While the level of circulating VEGF protein is increased in HCC patients and has been linked to poor oncological outcomes [ 45 ], the expression levels of VEGF protein also correlate directly with tumor size, metastasis, and poor prognosis in various malignancies [ 47 ]. Functional DNA sequence variations within the VEGF gene lead to altered serum levels and activity and, as such, also affect clinical outcomes in different types of malignant disease [ 48 , 49 ]. The VEGF C + 936T SNP has been associated with an increased susceptibility to breast, lung, and colon cancer as well as with a shorter disease-free survival in colon cancer [ 20 , 50 ].…”