Genetic Polymorphisms of the Interleukin-1 beta (IL-1.BETA.) -511 and +3954 Single Nucleotide Polymorphisms (SNPs) in Malaysian Systemic Lupus Erythematosus (SLE) Patients

Chua, Kek Heng; Lau, Tze-Pheng; Tee, Zhuang-Yun; Tan, Si-Yen; Lian, Lay-Hoong

doi:10.1248/jhs.55.657

Cited by 18 publications

(12 citation statements)

References 21 publications

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“…Similar statistical analysis as reported previously has been carried in this study (Chua et al, 2009b). The distribution of genetic polymorphisms was obtained by calculating both allelic and genotypic frequencies.…”

Section: Discussionsupporting

confidence: 54%

Lack of association between TYK2 and STAT3 genes and Crohn’s disease in the Malaysian population

Lian

Lau²,

Lee³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. This study aimed to investigate the potential association of TYK2 and STAT3 genes with the susceptibility to Crohn's disease (CD) among Malaysians. DNA samples were obtained from 80 CD patients and 100 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism methods were employed for genotyping, followed by statistical analysis. In our current study, none of the single nucleotide polymorphisms of either TYK2 or STAT3 was statistically associated with the susceptibility to CD in our local population (P > 0.05). In contrast, there was a statistically significant association between the G/G homozygotes of the STAT3 rs2293152 and the healthy control group (χ 2 = 6.229, P < 0.05). In conclusion, our study does not support the role of the TYK2 and STAT3 genes influencing CD susceptibility.

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Section: Discussionsupporting

confidence: 54%

Lack of association between TYK2 and STAT3 genes and Crohn’s disease in the Malaysian population

Lian

Lau²,

Lee³

et al. 2013

Genet. Mol. Res.

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“…Others studies have also shown the predominance of the ancestral allele (C), ranging from 60% to 70%. [27][28][29] We observed a higher frequency of CC genotype (51.0%), followed by CT (31.8%) and TT (17.2%). This is consistent with the previously cited studies.…”

Section: Discussionmentioning

confidence: 59%

“…This is consistent with the previously cited studies. [27][28][29] Pro-inflammatory cytokines are produced in various organ after tissue damage not only in experimental immune-response models but also in various types of insults, including infection, ischemia, trauma, cryo-ablation and burns, [12] by various types of cells, including residential immune-related cells (such as leukocytes, macrophages, microglia, and dendritic cells), neurons and glia in the central nervous system. [25] As disruption of the blood-labyrinth barrier is associated with increased permeability of blood vessels in the inner ear, inflammation may be related to the etiology of these inner ear diseases.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-1β gene polymorphism and hearing loss related to the history of occupational noise exposure in Brazilian elderly

et al. 2013

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Hearing loss is the most common sensory impairment in older people, and may have social and psychological consequences, such as social isolation, frustration and depression. Noise-induced hearing loss (NIHL) is an interaction of both genetic and environmental factors. Some studies have led to the identification of possible NIHL susceptibility genes. The aim of the present study was to investigate whether the polymorphism of the interleukin (IL)-1β gene at position + 3954 was associated with complaints of hearing loss due to occupational exposure. The sample was composed of elderly people with hearing loss (age ≥ 60 years) divided into two groups: 99 with occupational exposure to noise and 193 without exposure. Information on occupational exposure to noise was obtained through interviews using a semi-structured questionnaire. Hearing acuity was measured from 500 to 6000 Hz and the IL-1β genotype was obtained by the polymerase chain reaction- restriction fragment length polymorphism technique. Differences in allelic and genotypic frequencies, and the association between genotypic frequencies and complaints of hearing loss due to occupational exposure, were analyzed by the Chi-square test at the 5% significance level. Fifty-one percent of the elderly were homozygous for the ancestral allele (C), 17.2% were homozygous for the polymorphic allele (T) and 31.8% were heterozygous. The frequency was found to be 67-33% C to allele T. There was no significant association between polymorphism in gene IL-1β and hearing loss associated with occupational exposure (χ2 = 0.538; P = 0.676). No association was found with the polymorphism of the IL-1β +3954 C/T gene and hearing loss associated with the occupational noise exposure history.

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“…In Taiwan, no association between IL-1 β −511 C/T polymorphism and SLE was observed [53]. In a similar study carried out by Chua and coworkers [27], a significant correlation of another IL-1 β polymorphism (+3954 E1/E2 in exon 5) with SLE susceptibility in Malaysian population was noted, with E1 allele rather than the E2 at higher frequency among patients. This was also the case in Columbian SLE patients but not in the Taiwanese [53, 54].…”

Section: Candidate Genesmentioning

confidence: 99%

Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population: A Minireview

Chai

Phipps

Chua

2012

Clinical and Developmental Immunology

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SLE is an autoimmune disease that is not uncommon in Malaysia. In contrast to Malays and Indians, the Chinese seem to be most affected. SLE is characterized by deficiency of body's immune response that leads to production of autoantibodies and failure of immune complex clearance. This minireview attempts to summarize the association of several candidate genes with risk for SLE in the Malaysian population and discuss the genetic heterogeneity that exists locally in Asians and in comparison with SLE in Caucasians. Several groups of researchers have been actively investigating genes that are associated with SLE susceptibility in the Malaysian population by screening possible reported candidate genes across the SLE patients and healthy controls. These candidate genes include MHC genes and genes encoding complement components, TNF, FcγR, T-cell receptors, and interleukins. However, most of the polymorphisms investigated in these genes did not show significant associations with susceptibility to SLE in the Malaysian scenario, except for those occurring in MHC genes and genes coding for TNF-α, IL-1β, IL-1RN, and IL-6.

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Genetic Polymorphisms of the Interleukin-1 beta (IL-1.BETA.) -511 and +3954 Single Nucleotide Polymorphisms (SNPs) in Malaysian Systemic Lupus Erythematosus (SLE) Patients

Cited by 18 publications

References 21 publications

Lack of association between TYK2 and STAT3 genes and Crohn’s disease in the Malaysian population

Lack of association between TYK2 and STAT3 genes and Crohn’s disease in the Malaysian population

Interleukin-1β gene polymorphism and hearing loss related to the history of occupational noise exposure in Brazilian elderly

Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population: A Minireview

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