Genetic polymorphisms of T-1131C APOA5 and ALOX5AP SG13S114 with the susceptibility of ischaemic stroke in Morocco

Abstract

Ischaemic stroke is a multifactorial disease. Genetic polymorphisms involved in lipid, inflammatory and thrombotic metabolisms play an important role in the development of ischaemic stroke. The present study aimed to assess the relationship between T1131C APOA5 and SG13S114 ALOX5AP polymorphisms and the risk of ischemic stroke in 175 cases and 201 controls. Genotyping was performed by high resolution melting and polymerase chain reaction restriction fragment length polymorphism methods. In the case of T-1131C APOA5, a modest risk of ischaemic stroke was noticed with CC (OR: 2.86; 95% CI = 1.24-6.58; Pc = 0.039) and C allele (OR: 1.54; 95% CI = 1.01-2.33; Pc = 0.014). For SG13S114 ALOX5AP, a significant association was observed among subjects with TT (OR: 2.57; 95% CI =1.49-4.83; Pc = 0.009) and T allele (OR: 1.59; 95% CI = 1.16-2.19; Pc = 0.008). According to the risk factors of ischaemic stroke, a positive correlation was observed only between SG13S114 variant of ALOX5AP gene and hypertension (Pc = 0.026). Despite lower sample size, T-1131C APOA5 and SG13S114 variants could be considered an independent genetic risk factor of ischaemic stroke in Moroccan population.

<p>Lack of association between <em>ALOX5AP</em> genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses</p>

“…Imaging (magnetic resonance imaging/computerized tomography) examination of the brain to support the clinical diagnosis was conducted in all studies. The distribution of genotypes in the controls of all studies was in agreement with HWE except for the studies by Cheng et al, Zhao et al, Xu et al, and Diakite et al21,26,29,37 Table 1 displays the study characteristics for the identified studies.…”

The association of lipid metabolism relative gene polymorphisms and ischemic stroke in Han and Uighur population of Xinjiang

“…Recent data revealed that a few protein genetic polymorphisms were significantly association with the risk for stroke [22–24]. Here, we investigated that ApoA5, LPL, CETP and LDLR gene polymorphisms in IS patients from Xinjiang region.…”

Ischemic stroke in Morocco: a systematic review

“…Studies included in the present critical review of the literature have revealed several risk factors associated with cerebral ischemia in the local populations of interest. Indeed, high blood pressure (HBP), diabetes, smoking and heart disease were the four main risk factors listed and are as follows: HBP was reported in ( n = 20) studies (31 to 65.4%) [13, 15, 17, 18, 20, 21, 23, 25–28, 30, 33, 35–38, 40–42], diabetes in ( n = 20) studies (12–41.8%) [13, 15, 17, 18, 20, 21, 23, 25–28, 30, 33, 35–38, 40–42], cardiac diseases in 14 studies (7–44.3%) [13, 15, 17, 20, 21, 23, 25–28, 30, 33, 35, 42], atrial fibrillation as associated heart disease was specified in 9 studies (2,5–22%), and smoking in ( n = 19) studies (4–41.8%) [13, 15, 17, 18, 20, 21, 23, 25–28, 30, 33, 35, 37, 38, 40–42].…”

“…In addition to these risk factors, other risk factors have been reported such as dyslipidemia in ( n = 16) studies (0–61.8%) [13, 15, 17, 18, 20, 23, 25–28, 30, 33, 35–37, 42], obesity in ( n = 6) studies (10.7–26.1%) [13, 17, 18, 26, 30, 35], the notion of a previous stroke was noted in ( n = 10) hospital series (5–26.6%) [13, 15, 23, 25–28, 30, 32, 35], alcoholism in ( n = 10) studies [13, 15, 20, 25, 32, 33, 35, 38, 40, 41], oral contraception in ( n = 3) studies (6.6–12.2%) [30, 32, 33], and migraine in a single study at 6.5% [30].…”

“…In addition, the same study explored also the risk of IS related to SG13S114 ALOX5AP and showed a significant association with TT and T alleles. Despite the reduced sample size, variants of T-1131C APOA5 and SG13S114 could be considered as an independent genetic risk factor IS in the Moroccan population [38]. Furthermore, the fifth study by Balar (2014), showed that MTHFR gene (patients with MTHFR CT/ TT patients without CT/TT) and other factors (sex, age, HBP, diabetes, smoking, alcoholism, dyslipidemia) did not reveal significant correlation [36].…”