Genetic polymorphisms of superoxide dismutase 1 are associated with the serum lipid profiles of Han Chinese adults in a sexually dimorphic manner

Abstract

Inspired by the mechanistic correlations between superoxide dismutase 1 (SOD1) and lipid metabolism, the associations of SOD1 single nucleotide polymorphisms (SNPs) with circulating lipid levels were explored. In 2621 Chinese Han adults, randomly recruited from a health examination center without organic diseases, cancers, and pregnancy, three tag SNPs, rs4998557, rs1041740, and rs17880487 selected by Haploview software were genotyped with a probe-based real-time quantitative PCR method. In both genders, most parameters of the dyslipidemia adults were inferior (P < 0.001) to those of the non-dyslipidemia adults, and genotype frequencies of rs4998557 and rs17880487 were significantly different (P < 0.05) between the normal and abnormal subgroups of total cholesterol (TC) or highdensity lipoprotein cholesterol (HDLC). Adjusted for confounding factors, logistic regression analyses revealed that in males rs4998557A, rs1041740T, and rs17880487T reduced the risk of high TC and/or LDLC (P < 0.05), and rs4998557A and rs17880487T increased the risk of low HDLC (P < 0.05); but in females, none of the SNPs had associations with any of the lipid parameters (P > 0.05). Conclusively, characterized by a sexual dimorphism, the SOD1 polymorphisms were associated with the lipid disorders in the adult males but not females of the Chinese Han population.

Genetic variations of antioxidant genes and their association with male infertility in Vietnamese men

“…SOD1 and SOD2 play an important role in eliminating ROS and these antioxidant enzymes protect cells from free radicals and damage by oxidative stress. The polymorphism 7958G>A (rs4998557) of SOD1 was reported to be possibly associated with colorectal cancer, 30 sexually dimorphic manner, 31 sudden sensorineural hearing loss in the Japanese population, 32 or Alzheimer's disease 33 . To date, although there has been no study on the influence of SOD1 gene polymorphisms on infertility in humans, studies on mice have shown that there was impaired fertility in SOD1 deficient mouse sperm 34 or a decreased of spermatogenic cells in sod1‐knockout mice under heat stress 35 .…”

Molecular and genetic aspects of health risks and their association with adverse environmental conditions and diets (systemic review)

“…They are a widely spread group of antioxidant metallo-__________________________ proteinases, which consists altogether of three genetically different isoforms coded by the SOD1, SOD2, and SOD3 genes, the activity of which is apparent in the cytoplasm, mitochondria, and extracellular space, respectively. The best-studied SOD1 gene affects lipid metabolism by inhibiting activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [31,32]. Single nucleotide polymorphisms (SNPs) in workers exposed to occupational hazards can change gene activity, moderate the protein function, and have some other effects at the molecular level.…”