Genetic polymorphisms of reproductive hormones and their receptors in assisted reproduction technology for patients with polycystic ovary syndrome

Koloda, Yu.A.; Denisova, Yulia V.; Подзолкова, Н. М.

doi:10.1515/dmpt-2021-0123

Cited by 3 publications

(2 citation statements)

References 57 publications

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“…This surplus adipose tissue is thought to release a range of hormones and cytokines, such as estrogen and insulin-like growth factor 1 (IGF-1) [28,29]. The presence of these hormones may affect ovarian function by in uencing the production of estrogen in the local area, ultimately contributing to the onset of polycystic ovary syndrome (PCOS) [30]. Furthermore, a higher body mass index during childhood is indicative of a higher degree of insulin resistance [31].…”

Section: Discussionmentioning

confidence: 99%

Association between Childhood Obesity and Polycystic Ovary Syndrome: A Two-Sample Mendelian Randomization Study

Wei,

Wang,

Liu

et al. 2023

Preprint

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Background: The relationship between adult obesity and polycystic ovary syndrome(PCOS) have been previously reported, but the causal effect of childhood obesity on PCOS remains poorly understood. A two-sample Mendelian randomization analysis was performed to investigate the causal association of childhood obesity and PCOS. Methods: A genome-wide association study(GWAS)identifies SNPs associated with childhood obesity based on 13848 individuals of European ancestry. Data at the summary level for PCOS were obtained from a GWAS conducted by the FinnGen consortium, which included a large sample size of 118870 individuals, consisting of 642 cases and 118228 controls. Mendelian randomization（MR）methods including Inverse variance weighted (IVW), MR-Egger, weighted median, simple mode, and weighted mode analysis were performed in this study. Sensitivity analyses were conducted to evaluate the precision and robustness of the findings. Results: The impact of genetically determined childhood obesity on PCOS is substantial, as evidenced by the IVW analysis (OR=1.507, 95% CI 1.193-1.903; P=5.77×10−4) and the weighted median analysis (OR=1.578, 95% CI 1.829–2.104; P=1.91×10−3).The main findings were supported by sensitivity analyses, which yielded consistent estimates using the IVW and MR-Egger methods. Conclusion: It is suggested that an elevated prevalence of childhood obesity could be associated with an increased risk of PCOS. The prevention of PCOS should be promoted in childhood populations with high obesity. Additional investigation is necessary to confirm these discoveries and explore the underlying biological processes.

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Section: Discussionmentioning

confidence: 99%

Association between Childhood Obesity and Polycystic Ovary Syndrome: A Two-Sample Mendelian Randomization Study

Wei,

Wang,

Liu

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…Some studies have shown that excessive androgen in PCOS patients can promote the recruitment and growth of follicles, producing a large number of small and immature follicles, eventually leading to polycystic changes in the ovary. Conversely, when the follicle diameter reaches 2~8 mm, the increased androgen will promote atresia [ 3 , 4 ]. At the same time, these small follicles also secrete excessive levels of anti-Mullerian hormone to inhibit the aromatase activity induced by follicle-stimulating hormone (FSH) and hinder follicular development.…”

Section: Introductionmentioning

confidence: 99%

Cyproterone Acetate Mediates IRE1α Signaling Pathway to Alleviate Pyroptosis of Ovarian Granulosa Cells Induced by Hyperandrogen

Zhang

Xie

et al. 2022

Biology

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Objective: Hyperandrogenemia (HA) is the main pathophysiological change that takes place in polycystic ovary syndrome (PCOS). Cyproterone acetate (CYA) is a drug commonly used to reduce androgen in patients with PCOS. Long-term and continuous exposure to HA can cause ovarian granulosa cells (GCs), pyroptotic death, and follicular dysfunction in PCOS mice. The aim of this study was to investigate whether CYA could ameliorate the hyperandrogenemia-induced pyroptosis of PCOS ovarian GCs by alleviating the activation of the IRE1α signaling pathway. Methods: Firstly, thirty PCOS patients with HA as their main clinical manifestation were selected as the study group, and thirty non-PCOS patients were selected as the control group. The GCs and follicular fluid of the patients were collected, and the expression of pyroptosis-related proteins was detected. Secondly, a PCOS mouse model induced by dehydroepiandrosterone (DHEA) was constructed, and the treatment group model was constructed with the subcutaneous injection of cyproterone acetate in PCOS mice. The expression of pyroptosis-related protein in ovarian GCs was detected to explore the alleviating effect of CYA on the pyroptosis of ovarian GCs in PCOS mice. Thirdly, KGN cells-i.e., from the human GC line-were cultured with dihydrotestosterone, CYA, and ERN1 (IRE1α gene) small interfering RNA in vitro to explore whether CYA can alleviate the activation of the IRE1α signaling pathway and ameliorate the hyperandrogenemia-induced pyroptosis of PCOS ovarian GCs. Results: The expression of pyroptosis-related proteins was significantly increased in ovarian GCs of PCOS patients with HA as the main clinical manifestation, and in the PCOS mouse model induced by DHEA. After treatment with CYA, the expression of pyroptosis-related proteins in the ovarian GCs of mice was significantly lower than that in PCOS mice. In vitro experiments showed that CYA could ameliorate KGN cells’ pyroptosis by alleviating the activation of the IRE1α signaling pathway. Conclusion: This study showed that CYA could ameliorate the activation of the IRE1α signaling pathway in mouse GCs and KGN cells, and also alleviate pyroptosis in ovarian GCs. This study provides a new mechanism and evidential support for CYA in the treatment of PCOS patients.

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The Relationship between Thyroid Hormones and Insulin Resistance in Polycystic Ovary Syndrome Women

Hao,

Ma,

Zhang

et al. 2024

Gynecol Obstet Invest

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Objective: This study aimed to investigate the changes in thyroid hormones in the serum of patients with polycystic ovary syndrome (PCOS) and their correlation with insulin resistance. Design: This is a retrospective study. Participants: 84 patients having insulin resistance and 76 patients without insulin resistance were included. 90 women without history of PCOS were selected as a healthy control group. Settings: This study was conducted at Shijiazhuang Fourth Hospital. Methods: Blood samples were collected from each group on days 3-5 of their menstrual cycle, and their triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) levels were analyzed and compared between groups. Results: We investigated the changes of serum thyroid hormones in patients with PCOS and their correlation with insulin resistance. We found that serum levels of T3 and T4 were significantly decreased, while TSH levels were significantly increased in PCOS patients compared with healthy controls. Moreover, we found that patients with insulin resistance had significantly lower levels of serum T3 and T4 and higher levels of TSH compared to those PCOS participants without insulin resistance. Limitations: This study was a retrospective and single-center study, which had selection bias, information bias, and confounding variables may affect the accuracy and reliability of the conclusion. Conclusions: Insulin resistance negative correlates with their serum T3, T4, and positive correlates with their TSH levels. Our results develop a combined test model with the serum T3, T4 and TSH levels for the clinical diagnosis of insulin resistance in PCOS women.

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Genetic polymorphisms of reproductive hormones and their receptors in assisted reproduction technology for patients with polycystic ovary syndrome

Cited by 3 publications

References 57 publications

Association between Childhood Obesity and Polycystic Ovary Syndrome: A Two-Sample Mendelian Randomization Study

Association between Childhood Obesity and Polycystic Ovary Syndrome: A Two-Sample Mendelian Randomization Study

Cyproterone Acetate Mediates IRE1α Signaling Pathway to Alleviate Pyroptosis of Ovarian Granulosa Cells Induced by Hyperandrogen

The Relationship between Thyroid Hormones and Insulin Resistance in Polycystic Ovary Syndrome Women

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