Genetic Polymorphisms of NOD1 and IL-8, but not Polymorphisms of TLR4 Genes, Are Associated with Helicobacter pylori-Induced Duodenal Ulcer and Gastritis

Abstract

E266K CARD4/NOD1, but not the TLR4 gene polymorphism increases the risk of peptic ulceration in H. pylori-positive patients. The -251 IL-8 polymorphism was significantly associated with either gastritis or DU in H. pylori-infected subjects. Host factors including intracellular pathogen receptors and IL-8 production play an important role in H. pylori-induced gastric mucosal damage.

Volume 34 Number 3

“…Gil et al found that M. pneumoniae colonised at a higher rate in patients with asthma (24.7%) than those without (5.7%), possibly inducing the wheezing events 39 . Qasem and colleagues, in a study of both asthmatic and non-asthmatic patients, found that M. pneumoniae was more common in asthmatic patients and was also related to the exacerbation of asthma symptoms (patients with suspected viral infections were excluded from this study) 38 . In a study conducted in France of children with known asthma and children with a new diagnosis of asthma, Biscardi et al found that M. pneumoniae and C. pneumoniae were found in both groups of children, but at higher infection rates in those children with newly diagnosed asthma (50% of newly diagnosed patients had M. pneumoniae infection compared with 5.2% of stable asthma patients).…”

“…EBV infection is also associated with a number of non-Hodgkin's lymphomas (NHL), including Burkitt lymphoma (BL) and diffuse large B cell lymphoma (DLBCL) 38 . Although rare in Australia, EBVassociated BL is endemic in regions of Africa and Papua New Guinea 22 .…”

“…Recent studies of Mycoplasma pneumoniae, Chlamydia pneumoniae and Legionella pneumophila have looked at the associations of these atypical bacteria with both acute exacerbations and chronic cases of asthma 38 . Evidence from human studies have linked both M. pneumoniae and C. pneumoniae to cases of prevalent asthma and even new cases of wheezing indicating they could play possible roles in promoting airway inflammation 38 .…”

“…Evidence from human studies have linked both M. pneumoniae and C. pneumoniae to cases of prevalent asthma and even new cases of wheezing indicating they could play possible roles in promoting airway inflammation 38 . Gil et al found that M. pneumoniae colonised at a higher rate in patients with asthma (24.7%) than those without (5.7%), possibly inducing the wheezing events 39 .…”

Immunohistopathological Role of Bcl2 and P53 Gene Expression in Helicobacter Pylori Cytotoxin-Associated Gene a Positive Versus Cytotoxin-Associated Gene a Negative Antral Predominant Non-Atrophic Gastritis in Iraqi Patients

“…HP and inflammatory infiltrates start to produce oxidative stress in gastric microenvironment. HP-NAP stimulates (nicotinamide adenine dinucleotide) oxidase assembly and production of reactive oxygen species [41]. Neutrophils express the myeloperoxidase enzyme, which produces a powerful oxidant hypochlorous anion (OCl − ) from H 2 O 2 in the existence of Cl − .…”