Genetic Polymorphisms of Multidrug Resistance Gene‐1 (<i>MDR1/ABCB1</i>) and Glutathione S‐Transferase Gene and the Risk of Inflammatory Bowel Disease among Moroccan Patients

Senhaji, Nezha; Kassogue, Yaya; Fahimi, Mina; Serbati, Nadia; Badre, Wafaa; Nadifi, Sellama

doi:10.1155/2015/248060

Cited by 24 publications

(22 citation statements)

References 47 publications

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“…2.5.2.18) are belongs to a family of multifunctional enzymes which conjugate electrophilic intermediates with the endogenous tripeptide glutathione (GSH) [1]. GSTs are ubiquitous, multitalented enzymes which catalyse the nucleophilic addition of the glutathione (Glu-Cys-Gly) to numerous hazardous xenobiotic including phase I electrophilic and carcinogenic metabolites [2]. There are cytosolic, mitochondrial and membrane associated GSTs, but detoxification is the key function of cytosolic GSTs [1].…”

Section: Introductionmentioning

confidence: 99%

Glutathione S-transferases Detoxify Endogenous and Exogenous Toxic Agents- Minireview

Dasari¹

2017

JDVAR

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Oxidative stress can lead to different lesions in DNA which are direct modification of bases of nucleotides including single and double strands breaks. Among all the bases of the nucleotides, guanine is most susceptible to oxidative changes, due to its lower reduction potential and hydroxyl radicals interact with imidazole ring of this nitrogenous base [9]. The well-studied marker for AbstractGlutathione S-transferases (GSTs) are belongs to phage II detoxification enzymes which play an important role in detoxification/biotransformation of endogenous and exogenous toxic agents like reactive oxygen species (ROS), reactive nitrogen species (RNS) and xenobiotic including environmental carcinogens. The generation of reactive oxygen/nitrogen species is known as oxidative stress which causes molecular damage. Oxidation of proteins leads to loss of certain function. Oxidation of lipids causes the disruption of biological membrane. That the DNA mutation and oxidative DNA lesions which are critical in carcinogenesis. This mini review discussed about the detoxification role of GSTs against endogenous and exogenous toxic compounds.

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Section: Introductionmentioning

confidence: 99%

Glutathione S-transferases Detoxify Endogenous and Exogenous Toxic Agents- Minireview

Dasari¹

2017

JDVAR

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“…GSTs are widely distributed in nature and are present in both prokaryotes and eukaryotes as the principal Phase II detoxifying enzymes [2]. They constitute a superfamily of ubiquitous, multifunctional enzymes (GSTs; EC 2.5.1.18) which catalyze the nucleophilic addition of the tripeptide glutathione (GSH; g-Glu-Cys-Gly) to several hazardous xenobiotics, including phase I electrophilic and carcinogenic metabolites [3][4][5] thereby, neutralizing their electrophilic sites and rendering the products more water-soluble and facilitating their elimination from the cell by Phase III enzymes [6]. In addition, GSTs can serve as peroxidases, isomerases and thiol transferases [7].…”

Section: Introductionmentioning

confidence: 99%

Glutathione S Transferases: Biochemistry, Polymorphism and Role in Colorectal Carcinogenesis

Nissar¹,

Sameer²,

Rasool³

et al. 2017

J Carcinog Mutagen

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Glutathione S-transferases (GSTs) are enzymes detoxifying a wide range of hazardous substances both of endogenous or exogenous origin, such as reactive oxygen species (ROS) or xenobiotics and environmental carcinogens; thereby imparting protection to DNA against oxidative damage. GST gene polymorphisms on the other hand, exert an effect on the functioning of enzymes encoded by these genes at both gene expression level and the activity of the protein. In this way it may influence the possibility of detoxification of carcinogens, and consequently, the level of DNA damage; thus it may have an effect on the risk of development of cancer. In this review we aim to understand the function of GSTs in the xenobiotic metabolism and their role in modulation of colorectal cancer (CRC).

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“…There were five publications that assessed the association of the GSTT1 null genotype with CD and five publications for UC. Thus, we extracted 10 individual studies [17-21]. As a result, 16 individual studies from 11 publications were included in the analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Ernst et al reported the GSTT1 null genotype was not associated with UC or CD [19]. Previous studies also reported conflicting findings on the association between the GSTT1 null genotype and IBD [18, 21-24]. Therefore, we conducted a meta-analysis of observational studies to evaluate the association.…”

Section: Introductionmentioning

confidence: 99%

Glutathione S-Transferase T1 Null Genotype is Associated with Susceptibility to Inflammatory Bowel Disease

Qian¹,

Song

et al. 2017

Cell Physiol Biochem

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Background: The published literature contains conflicting results regarding the impact of the glutathione S-transferase T1 (GSTT1) null genotype on the susceptibility to inflammatory bowel disease. Therefore, we conducted a meta-analysis of observational studies to assess the association. Methods: We searched four online databases for eligible studies. The odds ratio (OR) with 95% CI was used to assess the gene-disease association. We also performed subgroup analyses by type of inflammatory bowel disease and ethnicity. Results: There were 16 individual studies from 11 publications included in the analysis. There were 3366 cases with inflammatory bowel disease and 6013 controls. The meta-analysis of all 16 studies showed the GSTT1 null genotype was associated with increased susceptibility to inflammatory bowel disease (OR = 1.98, 95%CI 1.39-2.84, P < 0.001). The subgroup analysis by ethnicity further identified an association between the GSTT1 null genotype and inflammatory bowel disease in Caucasians, Asians, and Africans. The GSTT1 null genotype was associated with both ulcerative colitis (OR = 1.96, P = 0.004) and Crohn’s disease (OR = 2.01, P = 0.022). The GSTT1 null genotype was still significantly associated with ulcerative colitis (OR = 1.63, P < 0.0001) and Crohn’s disease (OR = 1.40, P = 0.023) after adjusting for study heterogeneity. Conclusion: The GSTT1 null genotype is significantly associated with an increased susceptibility to inflammatory bowel disease and is a risk factor for both ulcerative colitis and Crohn’s disease.

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Genetic Polymorphisms of Multidrug Resistance Gene‐1 (MDR1/ABCB1) and Glutathione S‐Transferase Gene and the Risk of Inflammatory Bowel Disease among Moroccan Patients

Cited by 24 publications

References 47 publications

Glutathione S-transferases Detoxify Endogenous and Exogenous Toxic Agents- Minireview

Glutathione S-transferases Detoxify Endogenous and Exogenous Toxic Agents- Minireview

Glutathione S Transferases: Biochemistry, Polymorphism and Role in Colorectal Carcinogenesis

Glutathione S-Transferase T1 Null Genotype is Associated with Susceptibility to Inflammatory Bowel Disease

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