Genetic Polymorphisms of Matrix Metalloproteinases and Protein Levels in Chronic Obstructive Pulmonary Disease in a Mexican Population

Abstract

Polymorphisms in MMP2 and MMP9 but not in MMP1 and MMP12 are associated with the risk of COPD in the Mexican mestizo population.

MMP‐3 (–1171 5A/6A; Lys45Glu) variants affect serum levels of matrix metalloproteinase (MMP)‐3 and correlate with severity of COPD: A study of MMP‐3, MMP‐7 and MMP‐12 in a Tunisian population

“…Up to now, the association between the (–82) A/G variation and COPD risk was investigated in many studies, although the results remain controversial. Our findings agree with previous studies reporting a lack of correlation between the MMP‐12 (–82) A/G polymorphism and the risk of COPD among Mexican, Brazilian and Russian populations, although they are discordant with data from Hunninghake et al . and Tacheva et al .…”

Differential diagnosis of lung cancer, its metastasis and chronic obstructive pulmonary disease based on serum Vegf, Il-8 and MMP-9

“…However, our results are in agreement of another study, which showed MMP-9 as better prognostic marker than MMP-2 in patients with mixed types of lung cancer37. A limited literature exists studying the level of MMP-2 in COPD patients, which however were contradictory in terms of increased38 or decreased39 levels in COPD patients compared to healthy subjects. Our results also showed slight decrease in the level of MMP-2 in COPD patients (than HD), which is in agreement with the recent study39.…”

“…A limited literature exists studying the level of MMP-2 in COPD patients, which however were contradictory in terms of increased38 or decreased39 levels in COPD patients compared to healthy subjects. Our results also showed slight decrease in the level of MMP-2 in COPD patients (than HD), which is in agreement with the recent study39. Moreover, this study also showed genetic polymorphism and protein level variation in COPD patients of Mexican population.…”

Role of Genetic Susceptibility in Nicotine Addiction and Chronic Obstructive Pulmonary Disease

“…In MMP2, the homozygous genotype T of the polymorphism rs243865 (C-1306T), located in the intron, shows a significant association with the FEV1 decrease in Caucasian populations 127 , while in Tunisian populations, it was correlated with disease severity 128 . In Mexican populations, rs243864 and rs11646643 were associated with the risk of COPD, and in addition, MMP-2 serum levels were lower 129 .…”

“…Our group used SNP tagging and determined that the rs3918253 of MMP9 associated with COPD risk increased in serum levels in a group of patients with stable COPD 129 .…”