Genetic Polymorphisms of Immunoregulatory Proteins in Acute Renal Allograft Rejection

Krichen, Henda; Sfar, Imen; Jendoubi-Ayed, S.; Makhlouf, M.; Rhomdhane, Thouraya Ben; Bardi, R.; Aouadi, Houda; Abdallah, T. Ben; Ayed, K.; Gorgi, Yousr

doi:10.1016/j.transproceed.2009.08.032

Cited by 23 publications

(11 citation statements)

References 10 publications

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“…Krichen et al investigated the association of CTLA4 318, 49 and CD28 gene polymorphisms with renal transplant outcomes. The results did not show any significant differences between the genotypes or the allele distribution and acute rejection or non-acute rejection patients (Krichen et al, 2009). CTLA4 CT60 G allele and liver acute rejection were shown to be related in Muro et al's (2008) study, But in another study, Azarpira et al did not show any association between CTLA4 CT60 and liver acute rejection (Azarpira et al, 2010).…”

Section: Haplotype 3 Ctacgacggcmentioning

confidence: 87%

Association of genetic variation in co-stimulatory molecule genes with outcome of liver transplant in Iranian patients

Karimi

Motazedian

Abedi

et al. 2012

Gene

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Section: Haplotype 3 Ctacgacggcmentioning

confidence: 87%

Association of genetic variation in co-stimulatory molecule genes with outcome of liver transplant in Iranian patients

Karimi

Motazedian

Abedi

et al. 2012

Gene

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“…[15][16][17][18][19] In particular, some studies of genetic polymorphisms in human liver and kidney transplant have suggested that CTLA-4 may play a minor role in allograft rejection. 7,20 Many of the reports have been inconclusive 21 ; therefore, they can be considered as substantial genes for determining non-HLA risk related to organ transplant. Costimulatory molecules are important in regulating immune response, and polymorphisms are associated with the expression or function of these molecules in some parts of the genes for these molecules.…”

Section: Articlementioning

confidence: 99%

Untitled

Niknam

Karimi²,

Geramizadeh³

et al. 2017

Exp Clin Transplant

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Objectives: Costimulatory molecules are important factors determining the outcome of transplant. The aim of the present study was to investigate the effect of CTLA-4, CD28, PD-1, and ICOS gene polymorphisms on the outcome of kidney transplant. Materials and Methods: A total of 172 kidney transplant recipients were included in this study. There were 45 recipients (26%) who experienced acute rejection. The CTLA-4, PD-1, ICOS, and CD28 gene polymorphisms were evaluated by polymerase chain reaction and restriction fragment length polymorphism methods. Results: There were no differences between kidney transplant recipients with or without acute rejection in the distribution of genotypes and alleles of studied costimulatory molecules. Significant associations were observed between the AA genotype and the A allele of CTLA-4 1661 (P = .04, P = .05) and also CT and TT genotypes of PD-1.9 in the male compared with female subgroup of patients, with low frequency in the acute rejection group (P = .03; P = .04). Significant associations were observed between the AA genotype and the A allele of CTLA-4 -1661 (P = .02; P = .01) and also GA genotype of PD-1.3 (P = .03) in the male subgroup compared with female subgroup with low frequency of acute rejection. A significant association was observed between TC genotype of CD28 in the female compared with male subgroup of patients with high frequency of acute rejection (P = .05). Conclusions:The above results suggest that genetic polymorphisms of costimulatory molecules function as sex-dependent risk factors for development of acute rejection. Further studies are needed in different populations.

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“…Fourteen studies [5][6][7][8][9][10][11][12][13][14][15][16][17][18] reporting the relationship between CTLA4 +49A/G gene polymorphism and acute rejection risk in renal transplantation were recruited into this meta-analysis. The data of our interest were extracted, and the frequencies of G allele of CTLA4 +49A/G for case group and control group were calculated.…”

Section: Study Characteristicsmentioning

confidence: 99%

Association of cytotoxic T‐lymphocyte antigen 4 +49A/G gene polymorphism with acute rejection risk in renal transplantation

Yang

Chen

et al. 2017

Pediatric Transplantation

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The conclusions on the association between cytotoxic T-lymphocyte antigen 4 (CTLA4) +49A/G gene polymorphism and acute rejection risk in renal transplantation are still debated. This meta-analysis was performed to update the association between CTLA4 +49A/G and acute rejection risk in renal transplantation. The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method. Fourteen reports were included into this meta-analysis for the association of CTLA4 A/G gene polymorphism and acute rejection risk in renal transplantation, consisting of 962 acute rejection patients and 2084 non-acute rejection controls. The association between CTLA4 G allele/GG genotype and acute rejection risk in renal transplantation was found in this meta-analysis (G allele: OR=1.21, 95% CI: 1.03-1.44, P=.02; GG genotype: OR=1.37, 95% CI: 1.10-1.69, P=.004). However, the AA genotype was not associated with acute rejection risk in renal transplantation. In conclusion, CTLA4 G allele/GG genotype is associated with the acute rejection risk in renal transplantation.

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Genetic Polymorphisms of Immunoregulatory Proteins in Acute Renal Allograft Rejection

Cited by 23 publications

References 10 publications

Association of genetic variation in co-stimulatory molecule genes with outcome of liver transplant in Iranian patients

Association of genetic variation in co-stimulatory molecule genes with outcome of liver transplant in Iranian patients

Untitled

Association of cytotoxic T‐lymphocyte antigen 4 +49A/G gene polymorphism with acute rejection risk in renal transplantation

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