Genetic polymorphisms of ICAM 1 and IL28 as predictors of liver fibrosis severity and viral clearance in hepatitis C genotype 4

Rizk, Nasser; Derbala, Moutaz

doi:10.1016/j.clinre.2012.09.012

Cited by 20 publications

(17 citation statements)

References 28 publications

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“…Clinical researches showed that the level of sICAM-1 was significantly higher in HCC group than that in the benign tumor group and normal control group, and was positively correlated with the degree of cirrhosis (Jung et al, 2012). The same conclusion was detected at gene level (Rizk et al, 2012). Thus, sICAM-1 has a value of auxiliary diagnosis in AFP negative or suspicious positive patients.…”

Section: Significance Of Icam-1 In Hcc Diagnosis and Prognosissupporting

confidence: 73%

Expression and Role of ICAM-1 in the Occurrence and Development of Hepatocellular Carcinoma

Zhu¹,

Gong²

2013

Asian Pacific Journal of Cancer Prevention

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Intercellular adhesion molecule-1 (ICAM-1) is a member of the immunoglobulin superfamily, its main function being to participate in recognition and adhesion between cells. ICAM-1 is considered closely related to occurrence, development, metastasis and invasion process of hepatocellular carcinoma (HCC). A variety of inflammatory cytokines and stimulus affect its expression through the nuclear factor-kappa B (NF-κB) signal transduction pathway. In the initial stage of inflammation, hepatocirrhosis and tumor development, ICAM-1 is expressed differently, and has varied effects on different cells to promote occurrence of malignancy and metastasis. ICAM-1 has diagnostic significance for AFP-negative or suspected HCC, and may be a prognositic significance. It is thus widely used in studies as a biomarker which reflects cancer cells metastasis as well as curative effect of drugs. Many new treatments of HCC may be based on the effects of ICAM-1 on different levels of function.

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Section: Significance Of Icam-1 In Hcc Diagnosis and Prognosissupporting

confidence: 73%

Expression and Role of ICAM-1 in the Occurrence and Development of Hepatocellular Carcinoma

Zhu¹,

Gong²

2013

Asian Pacific Journal of Cancer Prevention

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“…The SNP selection was performed following the work of Ito et al (2011), and genotyping was performed as published previously by Rizk and Derbala (2012). Genomic DNA was extracted from EDTA whole blood samples using the QiaAmp DNA Blood Mini Kit #51166 (Qiagen GmbH, Hilden, Germany) followed by assessment of DNA concentration using a Nanodrop spectrophotometer.…”

Section: Genotyping Of 4 Polymorphism Variants (Snps) Of Il28bmentioning

confidence: 99%

The predictive value of IL28B rs12979860, rs11881222 and rs8099917 polymorphisms and IP-10 in the therapeutic response of Egyptian genotype 4 patients

et al. 2013

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In genotype 4 cases, the IL28B SNPs rs12979860 rs8099917, and rs11881222 are the strongest predictors of a response, while IP-10 is a strong negative biomarker of a response. Accounting for this factor is important in the individualization of treatment and enhances the degree of predictiveness of the IL28 polymorphism in the final treatment outcome. The frequent distribution of C, A and T alleles of IL28 polymorphism are higher among TVR, which may reflect sensitivity to prolonged course.

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“…During hepatic fibrosis, the activation of hepatic stellate cells and subsequent interaction of these cells with immune cells, mediated by ICAM-1, result in a positive feedback circuit, which promotes the formation of hepatic fibrosis [24]. In the present study, following the development of hepatic fibrosis in the model mice, the serum levels and mRNA levels of ICAM-1 increased.…”

Section: Discussionmentioning

confidence: 62%

Effect of Huagantongluofang, a Chinese Traditional Medicine, in Hepatic Fibrogenesis in a Mouse Model of Biliary Cirrhosis

Xuan¹,

Wen²,

Wang

et al. 2017

Cell Physiol Biochem

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Background: Biliary cirrhosis (BC) is a chronic cholestatic liver disease, in which hepatic fibrosis is an early symptom. This study aimed to identify the biological function and the therapeutic effect of a Chinese traditional medicine, HuaGanTongLuoFang (HGTLF), in a mouse model of BC. Methods: The mice (n = 72) were randomly divided into a sham group (n =12) and BC group (n = 60). The animals in the BC group were then randomly divided into five groups (n = 12 in each) and treated with three different doses of HGTLF, ureodeoxycholic acid (UDCA), or normal saline (the model group). Four weeks later, serum and liver tissues were obtained from all the animals for analyses. Hematoxylin and eosin (H&E) staining was used to quantify the hepatic morphology, while real-time PCR and Enzyme-linked immunosorbent assay (ELISA) were used to determine the level of hepatic fibrosis-related genes. Results: Compared with the model group, all three doses of HGTLF improved hepatic function, as well as reducing inflammation and fibrogenesis. The best therapeutic effect was observed in the high-dose HGTLF group. Furthermore, HGTLF contributed to down-regulation of hepatic fibrosis-related genes (platelet-derived growth factor [PDGF], transforming growth factor-β [TGF-β], p38, nuclear factor-κB [NF-kB], intercellular adhesion molecular-1 [ICAM-1], and tissue inhibitor of metalloproteinase-1 [TIMP-1]). Conclusion: The data suggested that HGTLF effectively improved liver function and the morphology of the liver tissue in a mouse model of BC, possibly via suppression of hepatic fibrosis-related signals.

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Genetic polymorphisms of ICAM 1 and IL28 as predictors of liver fibrosis severity and viral clearance in hepatitis C genotype 4

Cited by 20 publications

References 28 publications

Expression and Role of ICAM-1 in the Occurrence and Development of Hepatocellular Carcinoma

Expression and Role of ICAM-1 in the Occurrence and Development of Hepatocellular Carcinoma

The predictive value of IL28B rs12979860, rs11881222 and rs8099917 polymorphisms and IP-10 in the therapeutic response of Egyptian genotype 4 patients

Effect of Huagantongluofang, a Chinese Traditional Medicine, in Hepatic Fibrogenesis in a Mouse Model of Biliary Cirrhosis

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