Genetic polymorphisms of <i>cyclooxygenase‐2</i> and colorectal adenoma risk: The Self Defense Forces Health Study

Ueda, Naoyuki; Maehara, Yoshihiko; Tajima, O.; Tabata, Shinji; Wakabayashi, Keiji; Kono, Suminori

doi:10.1111/j.1349-7006.2007.00711.x

Cited by 20 publications

(14 citation statements)

References 29 publications

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“…No significant difference was detected in the frequency of SNP of the −765G>C SNP between patients and controls. The frequencies of the −1195G>A and −765G>C SNP in the healthy controls were similar to those obtained from a large Japanese population study 28 . These results suggest that the −1195GG genotype is protective against HCV infection.…”

Section: Resultssupporting

confidence: 83%

Cyclooxygenase‐2 gene promoter polymorphisms affect susceptibility to hepatitis C virus infection and disease progression

Sakaki¹,

Makino

Hiroishi³

et al. 2010

Hepatology Research

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Section: Resultssupporting

confidence: 83%

Cyclooxygenase‐2 gene promoter polymorphisms affect susceptibility to hepatitis C virus infection and disease progression

Sakaki¹,

Makino

Hiroishi³

et al. 2010

Hepatology Research

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“…One possible reason for COX-2 polymorphisms being only associated with certain cancer types (22,28,36,37,41) might be due to different cancers having distinct molecular signatures. For example, the lung carcinogenesis activation pathway occurs through a variety of mechanisms, including activating mutations in the genes for epidermal growth factor receptor ( EGFR ), KRAS , p53, and also echinoderm microtubule-associated protein-like 4 ( EML4 ) and anaplastic lymphoma kinase ( ALK ) fusions.…”

Section: Discussionmentioning

confidence: 99%

Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer

Moraes

Aran

et al. 2017

Molecular and Clinical Oncology

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The enzyme cyclooxygenase 2 (COX-2) is known to be involved in tumorigenesis and metastasis in certain types of cancer. Nevertheless, the prognostic value of COX-2 overexpression and its polymorphisms in patients with non-small cell lung cancer (NSCLC) have yet to be fully elucidated. The aim of the present study was to investigate the association between the three most commonly studied COX-2 gene polymorphisms (−1195 G/A, −765 G/C and 8473 T/C) with COX-2 expression and lung cancer risk in a Brazilian cohort. In the present hospital based, case-control retrospective study, 104 patients with NSCLC and 202 cancer free control subjects were genotyped for −1195 G/A, −765 G/C and 8473 T/C polymorphisms using allelic discrimination with a reverse transcription quantitative polymerase chain reaction method. COX-2 mRNA expression was analyzed in surgically resected tumors from 34 patients with NSCLC. The results revealed that COX-2 expression levels were higher in tumor tissue compared with normal lung tissue. However, this overexpression of COX-2 was not associated with the patient outcome, and furthermore, none of the analyzed polymorphisms were associated with the risk of developing lung cancer, COX-2 overexpression, or the overall survival of the patients with NSCLC. Taken together, the findings described in the present study do not support a major role for COX-2 polymorphisms and COX-2 overexpression in lung carcinogenesis within the Brazilian population.

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“…Thus, a final total of 38 case-control studies in 37 articles which met our inclusion criteria were identified, including 10814 cases and 16174 controls. Among 38 cases and controls, there were 20 case-controls of Asians (Hamajima et al, 2001;Koh et al, 2004;Liu et al, 2006;Guo et al, 2007;Tan et al, 2007;Chiang et al, 2008;Lin et al, 2008;Saxena et al, 2008;Ueda et al, 2008;Xing et al, 2008;Xu et al, 2008;Tang et al, 2009;Upadhyay et al, 2009;Zhao et al, 2009;Mittal et al, 2010;He et al, 2011;Chang et al, 2012;Li et al, 2012;Shin et al, 2012), 11 of Caucasians (Cox et al, 2004;Pereira et al, 2006;Hou et al, 2007;Moons et al, 2007;Sitarz et al, 2008;Andersen et al, 2009;Hoff et al, 2009;Iglesias et al, 2009;Kristinsson et al, 2009;Pereira et al, 2010;Daraei et al, 2012), 4 of Americans (Ulrich et al, 2005;Gunter et al, 2006;Gong et al, 2009;Thompson et al, 2009), and 1 of Africans (Bye et al, 2011), and 2 of Mixed (Bye et al, 2011;Wang et al, 2012). 9 investigated gastric cancer (Liu ...…”

Section: Study Inclusion and Characteristicsmentioning

confidence: 99%

“…9 investigated gastric cancer (Liu et al, 2006;Pereira et al, 2006;Hou et al, 2007;Saxena et al, 2008;Sitarz et al, 2008;Tang et al, 2009;Li et al, 2012;Shin et al, 2012), 16 investigated colorectal cancer (Hamajima et al, 2001;Cox et al, 2004;Koh et al, 2004;Ulrich et al, 2005;Gunter et al, 2006;Xing et al, 2008;Ueda et al, 2008;Andersen et al, 2009;Gong et al, 2009;Hoff et al, 2009;Iglesias et al, 2009;Thompson et al, 2009;Pereira et al, 2010;Daraei et al, 2012;Wang et al, 2012), 3 investigated oral cancer (Chiang et al, 2008;Lin et al, 2008;Mittal et al, 2010), 6 investigated esophageal cancer (Guo et al, 2007;Moons et al, 2007;Kristinsson et al, 2009;Upadhyay et al, 2009;Bye et al, 2011), and 4 investigated pancreatic cancer and hepatocellular carcinoma (HCC) (Xu et al, 2008;Zhao et al, 2009;He et al, 2011;Chang et al, 2012). Of these articles, 18 studies were performed in HB (Hamajima et al, 2001;Cox et al, 2004;Gunter et al, 2006;Pereira et al, 2006;…”

Section: Study Inclusion and Characteristicsmentioning

confidence: 99%

The -765G>C Polymorphism in the Cyclooxygenase-2 Gene and Digestive System Cancer: a Meta-analysis

Zhao

Cao²,

Zhu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Published data regarding associations between the -765G>C polymorphism in cyclooxygenase-2 (COX-2) gene and digestive system cancer risk have been inconclusive. The aim of this study was to comprehensively evaluate the genetic risk of the -765G>C polymorphism in the COX-2 gene for digestive system cancer. Materials and Methods: A search was performed in Pubmed, Medline (Ovid), Embase, CNKI, Weipu, Wanfang and CBM databases, covering all studies until Feb 10, 2014. Statistical analysis was performed using Revman5.2. Results: A total of 10,814 cases and 16,174 controls in 38 case-control studies were included in this meta-analysis. The results indicated that C allele carriers (GC+CC) had a 20% increased risk of digestive system cancer when compared with the homozygote GG (odds ratio (OR)=1.20, 95% confidence interval (CI), 1.00-1.44 for GC+CC vs GG). In the subgroup analysis by ethnicity, significant elevated risks were associated with C allele carriers (GC+CC) in Asians (OR = 1.46, 95% CI=1.07-2.01, and p=0.02) and Africans (OR=2.12, 95% CI=1.57-2.87, and p< 0.00001), but not among Caucasians, Americans and mixed groups. For subgroup analysis by cancer type (GC+CC vs GG), significant associations were found between the -765G>C polymorphism and higher risk for gastric cancer (OR=1.64, 95% CI=1.03-2.61, and p=0.04), but not for colorectal cancer, oral cancer, esophageal cancer, and others. Regarding study design (GC+CC vs GG), no significant associations were found in then population-based case-control (PCC), hospital-based case-control (HCC) and family-based case-control (FCC) studies. Conclusions: This meta-analysis suggested that the -765G>C polymorphism of the COX-2 gene is a potential risk factor for digestive system cancer in Asians and Africans and gastric cancer overall.

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Genetic polymorphisms of cyclooxygenase‐2 and colorectal adenoma risk: The Self Defense Forces Health Study

Cited by 20 publications

References 29 publications

Cyclooxygenase‐2 gene promoter polymorphisms affect susceptibility to hepatitis C virus infection and disease progression

Cyclooxygenase‐2 gene promoter polymorphisms affect susceptibility to hepatitis C virus infection and disease progression

Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer

The -765G>C Polymorphism in the Cyclooxygenase-2 Gene and Digestive System Cancer: a Meta-analysis

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