Genetic polymorphisms of GSTP1 and mEPHX correlate with oxidative stress markers and lung function in COPD

EPHX1 polymorphisms, COPD and asthma in 47,000 individuals and in meta-analysis

“…[2,7,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]) investigating the EPHX1 T113C and A139G polymorphisms in relation to COPD or emphysema as the primary end-point were included. Two minor studies were excluded from the analyses, because we were unable to retrieve the original papers despite contacting the corresponding authors.…”

“…They do not find any effect on the risk of COPD for either the T113C or the A139G polymorphisms. [13] HERSH [28] FU [27] BRØGGER [2] CHENG [26] PARK [25] ZIDZIK [24] VIBHUTI [23] MATHESON [22] KORYTINA [20] BUDHI [19] RODRIGUEZ [18] XIAO [17] TAKEYABU [16] YIM [15] PARK [14] SMITH [21] CHAPPELL [7] Overall . Meta-analysis of EPHX1 A139G genotype and risk of chronic obstructive pulmonary disease (COPD); overall and stratified analyses using both random and fixed effect models.…”

A bioinformatics strategy for detecting the complexity of Chronic Obstructive Pulmonary Disease in Northern Chinese Han Population

“…Although the physical function of SERPINE2 in COPD and emphysema has not yet been fully resolved, it is suggested that SERPINE2 may play an important role in the pathogenesis of COPD. For another COPD-related gene GSTP1, it has been reported that 105V/114V alleles of GSTP1 are associated with imbalanced oxidative stress and lung function in patients (Vibhuti et al, 2007). Similarly, DeMeo et al (2007) concluded that the apical-predominant emphysematous destruction is influenced by polymorphisms in the xenophobic enzymes of GSTP1.…”

“…Recently, a series of studies have implicated that COPD represents a complex disease with genetics contributions from multiple genes. For example, Vibhuti et al (2007) approved that 113H/139H alleles of mEPHX and 105V/114V alleles of GSTP1 and the combination of genotypes with same alleles are associated with imbalanced oxidative stress and lung function in COPD patients. A genome-wide linkage analysis in the Boston Early-Onset COPD study suggested that SERPINE2 may be associated with the COPD-related phenotypes (Palmer et al, 2003;Silverman et al, 2002).…”

Πολυμορφισμοί Των TLR2 Και TLR4 Στη Χρόνια Αποφρακτική Πνευμονοπάθεια

“…Το wt αλληλόµορφο (Ile105) συσχετίστηκε µε την ανάπτυξη της νόσου σε Ιάπωνες [85], την κατ' εξοχήν εντόπι-ση του εµφυσήµατος στους άνω λοβούς µεταξύ ασθενών µε διαπιστωµένο εµφύσηµα [82], και σε οµοζυγωτία µε την ταχεία έκπτωση της αναπνευστικής λειτουργίας σε άτοµα µε οικο-γενειακό ιστορικό νόσου [86]. Αντίθετα, σε Ινδούς διαπιστώθηκε ότι τα αλλήλια 105V και 114V, καθώς και ο απλότυπος 105V/114V εµφανίζονταν συχνότερα µεταξύ των ασθενών µε ΧΑΠ συγκριτικά µε υγιείς µάρτυρες [77]. Ωστόσο, δεν υπήρξε επαναληψιµότητα των αποτε-λεσµάτων σε µελέτες σε Κορεάτες [87] και σε Κινέζους [88,74].…”