Genetic polymorphisms of glutathione S-transferase Mu 1, glutathione S-transferase theta 1, and glutathione S-transferase P1 in oral squamous cell carcinoma: A case-control study in Iranian population

Yaghmaei, Bahram; Yaghmaei, Kaveh; Jafarian, Mohammad; Golmohammadi, Shima

doi:10.4103/0975-8844.169762

Cited by 6 publications

(7 citation statements)

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“…Table 1 shows a summary of the studied gene polymorphisms in these articles. Jahnke, 1996 [8]; Kihara, 1997 [9]; Cheng, 1999 [10]; Hanna, 2001 [11]; Gajecka, 2005 [12]; Ruwali, 2011 [13]; Yaghmaei, 2015 [14];…”

Section: Resultsmentioning

confidence: 99%

“…Maniglia, 2020 [15]; GSTT1 null Fernández-Mateos, 2019 [4]; Trizna, 1995 [7]; Jahnke, 1996 [8]; Cheng, 1999 [10]; Hanna, 2001 [11]; Gajecka, 2005 [12]; Ruwali, 2011 [13]; Yaghmaei, 2015 [14]; Maniglia, 2020 [15] GSTM3 A, B Jahnke, 1996 [8]…”

Section: Resultsmentioning

confidence: 99%

“…In one study, A/G and A/G+ G/G genotypes of GSTP1 Ile105Val (rs1695) polymorphism were associated with significantly decreased risk of HNSCC [13]. In contrast, in other studies, there were not significant differences between the frequency of alleles and genotypes of this polymorphism between the HNSCC group and control group [4,[14][15][16]. The GA + GG genotypes of this polymorphism were significantly higher in heavy smoking HNSCC patients compared to non-smokers and light-smokers and were associated with HNSCC risk in a tobacco dose-dependent manner [16].…”

Section: Gstp1mentioning

confidence: 91%

“…Fernández-Mateos, 2019 [4]; Ruwali, 2011 [13]; Yaghmaei, 2015 [14]; Maniglia, 2020 [15]; Cho, 2006 [16] C341T Maniglia, 2020 [15] CYP2D6 *1, * Fernández-Mateos, 2019 [4]; Sturgis, 1999 [19]; Olshan, 2002 [20]; Gajecka, 2005 [21]; Kietthubthew, 2006 [22]; Costa, 2016 [23] Arg399Gln Fernández-Mateos, 2019 [4]; Sturgis, 1999 [19]; Olshan, 2002 [20]; Gajecka, 2005 [21]; Kietthubthew, 2006 [22]; Costa, 2016 [23];…”

Section: Iie105valmentioning

confidence: 99%

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Gene polymorphisms and risk of head and neck squamous cell carcinoma: a systematic review

Rajabi-Moghaddam

Abbaszadeh

2022

Rep Pract Oncol Radiother.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Gstp1mentioning

confidence: 91%

Section: Iie105valmentioning

confidence: 99%

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Gene polymorphisms and risk of head and neck squamous cell carcinoma: a systematic review

Rajabi-Moghaddam

Abbaszadeh

2022

Rep Pract Oncol Radiother.

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“…GSTM1 and GSTT1 null genotype were associated with the decrease in enzyme activity and related to GSH antioxidant level of changes [8], [9]. The previous study showed that GSTM1 and GSTT1 gene polymorphism had an impact on some certain diseases [10], [11], [12], [13]. Several populations in the world showed that GSTM1 gene null polymorphism and/or GSTT1 had the risk of type 2 DM (T2DM) compared with healthy control group [14], [15].…”

Section: Introductionmentioning

confidence: 99%

Role of Glutathione S-transferase Mu 1 and Glutathione S-transferases Theta 1 Polymorphism in the Risk of Developing Type 2 Diabetes Mellitus at Universitas Sumatera Utara Hospital, Medan

Tala

Sari

2021

Open Access Maced J Med Sci

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BACKGROUND: Diabetes mellitus is associated with an increased production of reactive oxygen species (ROS) and a reduction in antioxidant defense. Glutathione S-transferases (GSTs) is group of multifunction antioxidant enzyme can be used as important biomarkers for DM.. GSTM1, T1 genes variant polymorphism result in decreased or loss of enzyme activity. AIM: The study aimed to evaluate the role of GSTM1 and GSTT1 gene polymorphism in the risk of developing T2DM. METHODS: GSTM1 and GSTT1 polymorphisms were genotyped in 87 T2DM patients and 87 healthy control group to analyze their association with T2DM susceptibility by using multiplex Polymerase Chain Reaction (PCR). PCR products were electrophoresed using agarose 2%. Odds ratio (OR) with 95% confidence interval (CI) and P value were calculated using SPSS software (version 21.0). RESULTS: The genotype distribution of GSTM1 and GSTT1 were not different between T2DM patients and healthy control group (p = 0.542, OR= 0.780, CI 95%=0.350-1.737 and p=0.879, OR=1.047, CI 95%=0.577-1.903). The genotype distribution of combination of GSTM1 and GSTT1 were also not not different between T2DM patients and healthy control group (p = 0.640, OR= 0.640, CI 95%=0.224-1.83 and p=0.551, OR=0.721, CI 95%=0.245-2.120. CONCLUSION: In summary, this study showed that GSTT1 null, GSTM1 null, the combination of GSTM1 null and GSTT1 null genotype or combination of GSTM1 null and GSTT1 positive (or contrary) did not have any risk of developing T2DM at Universitas Sumatera Utara Hospital, Medan.

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The chemical changes in the total antioxidant status and biological activity of GSTP1 polymorphism on nasopharyngeal carcinoma patients

Farhat

Sari

Chrestella

et al. 2021

IOP Conf. Ser.: Earth Environ. Sci.

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Oxidative stress is associated with cancer, including NPC, which is developed by the relation of genetic alteration, EBV infection, and environmental risk. Ile/Val genotype of GSTP1 polymorphism decrease enzyme functions and result in lower total antioxidant status. This study aimed to identify the association of GSTP1 polymorphism and the TAS level. This was a cross-sectional design study. There were 29 NPC patients with their blood as the samples of the study. Blood as the samples for identifying GSTP1 polymorphism by PCR-RFLP-electrophoresis method and measurement of TAS using the ELISA method. There were 21 (72.4%) NPC patients with Ile/Val polymorphism and lower TAS. We found there was no significant association of GSTP1 polymorphism and TAS. Future research with larger samples and adding data about environmental risk such as smoking, alcohol consumption, and toxic substances exposure or multivitamin consumption of the patients can reveal more definitive results. The study may be used as references for determining antioxidant therapy in NPC as well as prevention. The identifying genetic risk factor may help the prevention of NPC.

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Genetic polymorphisms of glutathione S-transferase Mu 1, glutathione S-transferase theta 1, and glutathione S-transferase P1 in oral squamous cell carcinoma: A case-control study in Iranian population

Cited by 6 publications

References 0 publications

Gene polymorphisms and risk of head and neck squamous cell carcinoma: a systematic review

Gene polymorphisms and risk of head and neck squamous cell carcinoma: a systematic review

Role of Glutathione S-transferase Mu 1 and Glutathione S-transferases Theta 1 Polymorphism in the Risk of Developing Type 2 Diabetes Mellitus at Universitas Sumatera Utara Hospital, Medan

The chemical changes in the total antioxidant status and biological activity of GSTP1 polymorphism on nasopharyngeal carcinoma patients

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