Genetic polymorphisms of glucocorticoid receptor and their association with new-onset diabetes mellitus in kidney transplant recipients

Azadi, Soha; Azarpira, Negar; Roozbeh, Jamshid; Ezzatzadegan-Jahromi, Shahrokh; Raeesjalali, Ghanbar A.; Foroughinia, Farzaneh; Karimzadeh, Iman

doi:10.1016/j.gene.2022.147138

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…These SNPs are associated with reduced glucocorticoid sensitivity and increased vulnerability to developing PTSD following trauma exposure. Homozygous carriers of the Bcl-1 polymorphism (rs41423247) have been shown to have a higher risk of major depression and PTSD, as well as increased rates of suicide [ 18 , 19 , 20 ]. The 9β SNP variation in NR3C1 has also been linked to altered glucocorticoid sensitivity and investigated in relation to PTSD [ 21 ].…”

Section: Catalytic Factors Associated With Ptsdmentioning

confidence: 99%

Assessing and Modelling of Post-Traumatic Stress Disorder Using Molecular and Functional Biomarkers

Skolariki

Vrahatis

Krokidis

et al. 2023

Biology

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Post-traumatic stress disorder (PTSD) is a complex psychological disorder that develops following exposure to traumatic events. PTSD is influenced by catalytic factors such as dysregulated hypothalamic-pituitary-adrenal (HPA) axis, neurotransmitter imbalances, and oxidative stress. Genetic variations may act as important catalysts, impacting neurochemical signaling, synaptic plasticity, and stress response systems. Understanding the intricate gene networks and their interactions is vital for comprehending the underlying mechanisms of PTSD. Focusing on the catalytic factors of PTSD is essential because they provide valuable insights into the underlying mechanisms of the disorder. By understanding these factors and their interplay, researchers may uncover potential targets for interventions and therapies, leading to more effective and personalized treatments for individuals with PTSD. The aforementioned gene networks, composed of specific genes associated with the disorder, provide a comprehensive view of the molecular pathways and regulatory mechanisms involved in PTSD. Through this study valuable insights into the disorder’s underlying mechanisms and opening avenues for effective treatments, personalized interventions, and the development of biomarkers for early detection and monitoring are provided.

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Section: Catalytic Factors Associated With Ptsdmentioning

confidence: 99%

Assessing and Modelling of Post-Traumatic Stress Disorder Using Molecular and Functional Biomarkers

Skolariki

Vrahatis

Krokidis

et al. 2023

Biology

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“…There are some risks associated with constant immunosuppression, such as various bacterial, fungal, or viral infections, opportunistic infections, cancer, and metabolic complications. Therefore, an optimal balance between over- and under-immunosuppression must be maintained [ 6 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Endobiogenic Biology of Function Indices in a Cohort of Kidney Transplant Recipients

Mačionienė,

Serapinas,

Miglinas

2024

Medicina

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Background and Objectives: Endobiogeny is a global systems approach to human biology based on the concept that the endocrine system manages the metabolism. Biology of function (BoF) indices are diagnostic tools in endobiogenic medicine that reflect the action of the endocrine system on the cells and the metabolic activity of an organism. Kidney transplant recipients are a very specific patient population due to their constant use of immunosuppressive agents such as steroids and anamnesis of chronic kidney disease. The aim of this study was to assess the tendencies of endobiogenic BoF indices in a kidney transplant recipient population and to determine the relationship between BoF index values and histology-proven kidney transplant rejection. Materials and Methods: A total of 117 kidney transplant recipients undergoing surveillance or indication allograft biopsy were included in this study. Endobiogenic BoF indices were calculated from complete blood count tests taken before the kidney biopsy. Histology samples were evaluated by an experienced pathologist according to the Banff classification system. Clinical and follow-up data were collected from an electronic patient medical record system. Results: Overall, <35% of the patients had BoF index values assumed to be normal, according to the general population data. Additionally, >50% of the patients had lower-than-normal adaptation, leucocyte mobilization, genital, and adjusted genital ratio indices, while the Cata-Ana, genito-thyroid ratio, adrenal gland, and cortisol indices were increased in >50% of the transplant recipients. The adaptation index was significantly higher in patients with biopsy-proven transplant rejection and demonstrated an AUC value of 0.649 (95%CI 0.540–0.759) for discriminating rejectors from patients without transplant rejection. Conclusions: Most of the kidney transplant recipients had abnormal BoF index values, reflecting increased corticotropic effects on their cells. The adaptation index distinguished patients with biopsy-proven transplant rejection from those without it.

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Posttransplant complications: molecular mechanisms and therapeutic interventions

Liu,

Shen,

Yan

et al. 2024

MedComm

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Posttransplantation complications pose a major challenge to the long‐term survival and quality of life of organ transplant recipients. These complications encompass immune‐mediated complications, infectious complications, metabolic complications, and malignancies, with each type influenced by various risk factors and pathological mechanisms. The molecular mechanisms underlying posttransplantation complications involve a complex interplay of immunological, metabolic, and oncogenic processes, including innate and adaptive immune activation, immunosuppressant side effects, and viral reactivation. Here, we provide a comprehensive overview of the clinical features, risk factors, and molecular mechanisms of major posttransplantation complications. We systematically summarize the current understanding of the immunological basis of allograft rejection and graft‐versus‐host disease, the metabolic dysregulation associated with immunosuppressive agents, and the role of oncogenic viruses in posttransplantation malignancies. Furthermore, we discuss potential prevention and intervention strategies based on these mechanistic insights, highlighting the importance of optimizing immunosuppressive regimens, enhancing infection prophylaxis, and implementing targeted therapies. We also emphasize the need for future research to develop individualized complication control strategies under the guidance of precision medicine, ultimately improving the prognosis and quality of life of transplant recipients.

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Genetic polymorphisms of glucocorticoid receptor and their association with new-onset diabetes mellitus in kidney transplant recipients

Cited by 3 publications

References 42 publications

Assessing and Modelling of Post-Traumatic Stress Disorder Using Molecular and Functional Biomarkers

Assessing and Modelling of Post-Traumatic Stress Disorder Using Molecular and Functional Biomarkers

Endobiogenic Biology of Function Indices in a Cohort of Kidney Transplant Recipients

Posttransplant complications: molecular mechanisms and therapeutic interventions

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