Genetic polymorphisms of FAS and EVER genes in a Greek population and their susceptibility to cervical cancer: a case control study

Abstract

BackgroundThe aim of the study was to evaluate the association of two SNPs of EVER1/2 genes’ region (rs2290907, rs16970849) and the FAS-670 polymorphism with the susceptibility to precancerous lesions and cervical cancer in a Greek population.MethodsAmong the 515 women who were included in the statistical analysis, 113 belong to the case group and present with precancerous lesions or cervical cancer (27 with persistent CIN1, 66 with CIN2/3 and 20 with cervical cancer) and 402 belong to the control group. The chi-squared test was used to compare the case and the control groups with an allelic and a genotype-based analysis.ResultsThe results of the statistical analysis comparing the case and the control groups for all the SNPs tested were not statistically significant. Borderline significant difference (p value = 0.079) was only found by the allelic model between the control group and the CIN1/CIN2 patients’ subgroup for the polymorphism rs16970849. The comparison of the other case subgroups with the control group did not show any statistically significant difference.ConclusionsNone of the SNPs included in the study can be associated with statistical significance with the development of precancerous lesions or cervical cancer.

Genetic Susceptibility for Cervical Cancer in African Populations: What Are the Host Genetic Drivers?

“…In addition, Zoodsma et al (2005) showed a relationship between FasR 670A ‡G and increased risk of adenocarcinoma and not squamous cell carcinoma of the cervix. However, in another study conducted in Chinese women, as well as in Caucasian populations, there was no association between Fas SNPs and cervical cancer susceptibility (Chen et al, 2013;Du et al, 2013;Engelmark et al, 2004b;Pavlidou et al, 2016;Sun et al, 2005) resonating with the findings from African populations (Table 3).…”

“…The FasR 670G Allele is correlated with high-grade squamous intraepithelial lesions. The impact of the 670A ‡G change in the FASR gene decreases FAS expression, thus, abolishing gamma interferon signal transduction, leading to decreased apoptotic activity (Pavlidou et al, 2016). The FasR 670A allele is more common in Caucasians (51%) compared with Africans (29.5%) (Dybikowska et al, 2004;Lai et al, 2003;Pinti et al, 2002).…”

Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions

“…Cervical cancer is estimated to be the fourth most frequent type of cancer among women worldwide ( 1 ) and the fourth leading cause of cancer-related mortality ( 1 – 3 ). Environmental factors, living habits and human papillomavirus (HPV) infection have been linked to the development of cervical cancer ( 4 – 6 ).…”

“…Specifically, HPV infection is considered to be one of the most important causal factors related to cervical cancer ( 7 ). However, HPV alone, appears to not be sufficient for the development of cervical cancer ( 8 ), as only a small amount of HPV-infected women finally develop cervical cancer ( 3 , 9 ).…”

“…A number studies have provided evidence of familial clustering of cervical cancer, supporting the existence of genetic effects ( 10 – 12 ). Moreover, several association studies have demonstrated a number of genetic variants that possibly confer susceptibility to cervical cancer by affecting immune responses, DNA repair or viral cell entry and infection ( 3 , 13 , 14 ). However, uncertainty for the effect size of genetic variants, particularly in different ethnic backgrounds still exists, as the results of different genetic studies have been conflicting ( 13 ).…”