Genetic Polymorphisms of Estrogen Receptors in Patients with Premature Coronary Artery Disease

Mansur, Antônio de Pádua; Nogueira, Carlos César Montezino; Strunz, Célia Maria Cássaro; Aldrighi, José Mendes; Ramires, José Antônio Franchini

doi:10.1016/j.arcmed.2005.04.002

Cited by 66 publications

(57 citation statements)

References 32 publications

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“…Our results are inconsistent with the previous findings in non-Chinese populations, indicating significant associations between the ER-α gene and BMI variation in postmenopausal Caucasian women [20] , middle-aged Japanese women [22] , postmenopausal white women [21] , African-American families [24] , Brazilian subjects [25] , and men from the Framingham Heart Study [23] . However, our findings are consistent with the two previous studies performed on Chinese females [26,27] and a study in women from the Framingham Heart Study showing no effect of the ER-α gene on BMI variation [23] .…”

Section: Discussioncontrasting

confidence: 57%

“…ER and progesterone receptor status was used to define breast cancer risk factors [19] . Polymorphisms in the ER-α gene have been reported to be associated with BMI, though contradictory results were also reported [20][21][22][23][24][25][26][27] . Osteocalcin, also called bone Gla protein (BGP), is an osteoblast-specific protein that is known to play a role in bone growth and has recently been reported to function as a new metabolic hormone regulating the adiposity and glucose homeostasis in experimental animals [28][29][30] .…”

Section: Introductionmentioning

confidence: 78%

“…Recent studies of the association between the ER-α gene polymorphism and BMI have yielded conflicting results [20][21][22][23][24][25][26][27] . Our results are inconsistent with the previous findings in non-Chinese populations, indicating significant associations between the ER-α gene and BMI variation in postmenopausal Caucasian women [20] , middle-aged Japanese women [22] , postmenopausal white women [21] , African-American families [24] , Brazilian subjects [25] , and men from the Framingham Heart Study [23] .…”

Section: Discussionmentioning

confidence: 99%

“…The polymorphism of the PvuII site in the ER-α gene is the most extensively studied genetic marker in relation to BMI variation. However, the results so far have been largely inconsistent and controversial [20][21][22][23][24][25][26][27] . In addition, no data have been provided about the associations between BGP polymorphisms and BMI variation.…”

Section: Introductionmentioning

confidence: 99%

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Association analysis of genetic polymorphisms and potential interaction of the osteocalcin (BGP) and ER-α genes with body mass index (BMI) in premenopausal Chinese women

Xiao

Luo

et al. 2010

Acta Pharmacol Sin

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Aim: To investigate whether estrogen receptor α (ER-α) PvuII and osteocalcin (also known as bone Gla protein, or BGP) HindIII genetic polymorphisms and their potential interactions are associated with body mass index (BMI) variation. Methods: Data on BMI and ER-α PvuII and BGP HindIII genotypes were obtained from 328 healthy premenopausal Chinese women in east China. The study subjects were unrelated, at least 21 years old (mean age of 33.2±5.9 years), and had an average BMI of 21.58±2.59. All subjects were genotyped at the ER-α PvuII and BGP HindIII loci using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Results: The BGP HindIII genotypes were significantly associated with BMI (P=0.003). Carriers of the HH and Hh genotypes had approximately 2.73% and 1.27% higher BMI than those of the hh genotype, respectively. In contrast, the ER-α PvuII polymorphism was not significantly associated with BMI (P=0.454). In addition, there was no evidence of potential interactions between the ER-α and BGP genes in our subjects (P≥0.013). Conclusion:The HindIII polymorphism of the BGP gene, but not the PvuII polymorphism of the ER-α gene or their potential interaction, was associated with BMI in premenopausal Chinese women.

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Section: Discussioncontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association analysis of genetic polymorphisms and potential interaction of the osteocalcin (BGP) and ER-α genes with body mass index (BMI) in premenopausal Chinese women

Xiao

Luo

et al. 2010

Acta Pharmacol Sin

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“…However, the striking findings among overweight women, for whom ESR2 polymorphisms had a profound impact on prognosis, point towards the field of gene-environment interaction. The findings demonstrated in this study are in line with other studies on ESR2 polymorphisms and anthropometrics, i.e., an inverse relation between one ESR2 haplotype and overweight [11,16,25]. In the field of prostate cancer, Chae et al found an interactive association between BMI and genotypes of ESR2 and prostate cancer risk [2].…”

supporting

confidence: 92%

Given breast cancer, is fat better than thin? Impact of the estrogen receptor beta gene polymorphisms

Borgquist

Hjertberg

Henningson

et al. 2012

Breast Cancer Res Treat

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Given breast cancer, is fat better than thin? Impact of the estrogen receptor beta gene polymorphisms.Borgquist, Signe; Hjertberg, Maria; Henningson, Maria; Ingvar, Christian; Rose, Carsten; Jernström, Helena Link to publication Citation for published version (APA): Borgquist, S., Hjertberg, M., Henningson, M., Ingvar, C., Rose, C., & Jernström, H. (2013). Given breast cancer, is fat better than thin? Impact of the estrogen receptor beta gene polymorphisms. Breast Cancer Research and Treatment, 137(3), 849-862. DOI: 10.1007/s10549-012-2367-z General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Fewer studies have focused on the prognostic impact of ERβ polymorphisms. Therefore, we analyzed the associations between four previously identified haplotype tagging single nucleotide polymorphisms (htSNPs), associated haplo-and diplotypes, and breast cancer-free survival according to body constitution.The patient cohort included 634 women from the prospective breast cancer and blood study (BC-Blood study, Sweden) with a median follow-up of 4.92 years. Four htSNPs (i.e., rs4986938, rs1256049, rs1256031, rs3020450) in the ESR2 gene and the correlating haploand diplotypes were analyzed and correlated to selected patient and tumor characteristics and to disease-free survival, including stratification for BMI. Based on the four htSNPs, seven haplotypes and eight diplotypes were identified. The patient and tumor characteristics were well-balanced across all geno-and haplotypes. Disease-free survival differed according to rs4986938 and rs1256031 (Log-Rank p=0.045 and p=0.041, respectively) and the number of haplotype copies of the wildtype CCGC and TCAC (Log-Rank p=0.027 and p=0.038, respectively). In the survival analyses stratified for BMI, significant survival differences between alleles were observed among overweight women (rs4986938 and rs1256031 with Log-Rank p=0.001 and p=0.001, respectively). The BMI-stratified survival analyses based on haplotypes showed shorter disease-free survival for overweight women with null copies of CCGC (Log-Rank p=0.001) and for overweight women with any TCAC copy (Log-Rank p<0.0001). Markedly impaired disease-free survival was found for genotypes in two out of four ESR2 htSNPs and for two haplotypes.3 ESR2 polymorphisms seem to divide patients into good and poor survivors based on BMI, stressing the need of taking host factors into consideration in the evaluation of prognostic markers.

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Erratum: Analytical and compositional aspects of isoflavones in food and their biological effects

2009

Molecular Nutrition Food Res

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Genetic Polymorphisms of Estrogen Receptors in Patients with Premature Coronary Artery Disease

Cited by 66 publications

References 32 publications

Association analysis of genetic polymorphisms and potential interaction of the osteocalcin (BGP) and ER-α genes with body mass index (BMI) in premenopausal Chinese women

Association analysis of genetic polymorphisms and potential interaction of the osteocalcin (BGP) and ER-α genes with body mass index (BMI) in premenopausal Chinese women

Given breast cancer, is fat better than thin? Impact of the estrogen receptor beta gene polymorphisms

Erratum: Analytical and compositional aspects of isoflavones in food and their biological effects

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