Genetic Polymorphisms of Drug-Metabolizing Enzymes and Anti-TB Drug-Induced Hepatitis

Kim, Sang Heon; Kim, Sang Hoon; Bahn, Jae Hoon; Kim, Yoon Keun; Chang, Yoon-Seok; Shin, Eak Kyun; Kim, Youn Seup; Park, Jae Seuk; Kim, Bo Hyung; Jang, In Jin; Song, Junghan; Kim, Seung Hyun; Park, Hae‐Sim; Min, Kyung Up; Jee, Young Koo

doi:10.2217/pgs.09.100

Cited by 66 publications

(68 citation statements)

References 36 publications

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“…• Antituberculous drug induced hepatitis: CYP2E1 in the Chinese [127] (but not in Korean and British), NAT2 (Nacetyltransferase) in Koreans [128] and GST (glutathione-S-transferase) genotypes in Caucasians [129].…”

Section: Genetics Of Drug Allergymentioning

confidence: 99%

Epidemiology and risk factors for drug allergy

Thong

Tan

2011

Brit J Clinical Pharma

290

217

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The aim of this review was to describe the current evidence-based knowledge of the epidemiology, prevalence, incidence, risk factors and genetic associations of drug allergy. Articles published between 1966 and 2010 were identified in MEDLINE using the key words adult, adverse drug reaction reporting systems, age factors, anaphylactoid, anaphylaxis, anaesthetics, antibiotics, child, drug allergy, drug eruptions, ethnic groups, hypersensitivity, neuromuscular depolarizing agents, neuromuscular nondepolarizing agents, sex factors, StevensJohnson syndrome and toxic epidermal necrolysis. Additional studies were identified from article reference lists. Relevant, peer-reviewed original research articles, case series and reviews were considered for review. Current epidemiological studies on adverse drug reactions (ADRs) have used different definitions for ADR-related terminology, often do not differentiate immunologically and non-immunologically mediated drug hypersensitivity, study different study populations (different ethnicities, inpatients or outpatients, adults or children), utilize different methodologies (spontaneous vs. non-spontaneous reporting, cohort vs. case-control studies), different methods of assessing drug imputability and different methods of data analyses. Potentially life-threatening severe cutaneous adverse reactions (SCAR) are associated with a high risk of morbidity and mortality. HLA associations for SCAR associated with allopurinol, carbamazepine and abacavir have been reported with the potential for clinical use in screening prior to prescription. Identification of risk factors for drug allergy and appropriate genetic screening of at-risk ethnic groups may improve the outcomes of drug-specific SCAR. Research and collaboration are necessary for the generation of clinically-relevant, translational pharmacoepidemiological and pharmacogenomic knowledge, and success of health outcomes research and policies on drug allergies.

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Section: Genetics Of Drug Allergymentioning

confidence: 99%

Epidemiology and risk factors for drug allergy

Thong

Tan

2011

Brit J Clinical Pharma

290

217

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“…The variation in the association of GST gene polymorphism in different ethnic groups was also found in the Spanish population; the GST T1/T1 genotype was significantly associated with anti-TB drug-induced hepatitis instead of the GST M1/M1 genotype [83]. The other drug-metabolizing enzymes including CYP2C9, CYP2C19, CYP2D6, UGT1A1, and UGT1A3 have also been investigated in a Korean population; however, no significant association was found [74 ].…”

Section: Adverse Reactions Associated With Antituberculus Drugsmentioning

confidence: 94%

“…Therefore, most genetic studies have focused on a few enzymes involved in metabolism including the cytochrome P450 (CYP450) enzymes [69][70][71][72][73]74 ], the hepatic enzyme N-acetyltransferase 2 (NAT2) [72,74 ,75-81], GST [82,83], and manganese superoxide dismutase (MnSOD) [84] (Table 4). The CYP2E1c1/c1 genotype has been found to be a genetic risk factor by increasing CYP2E1 activity and the production of hepatotoxic metabolites of these drugs [70].…”

Section: Adverse Reactions Associated With Antituberculus Drugsmentioning

confidence: 99%

Genetic and ethnic risk factors associated with drug hypersensitivity

Kim

Palikhe

et al. 2010

Current Opinion in Allergy &Amp; Clinical Immunology

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“…Several studies have examined the associations between genetic polymorphisms in NAT2 and the risk of hepatotoxicity across different ethnicities [60,62,65–67,174,176]. NAT2 polymorphisms that define its phenotypic acetylator status are shown in Table 3 [62,174].…”

Section: Antituberculous Drugsmentioning

confidence: 99%

Pharmacogenomics of Antimicrobial Agents

et al. 2014

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Antimicrobial efficacy and toxicity varies between individuals owing to multiple factors. Genetic variants that affect drug-metabolizing enzymes may influence antimicrobial pharmacokinetics and pharmacodynamics, thereby determining efficacy and/or toxicity. In addition, many severe immune-mediated reactions have been associated with HLA class I and class II genes. In the last two decades, understanding of pharmacogenomic factors that influence antimicrobial efficacy and toxicity has rapidly evolved, leading to translational success such as the routine use of HLA-B*57:01 screening to prevent abacavir hypersensitivity reactions. This article examines recent advances in the field of antimicrobial pharmacogenomics that potentially affect treatment efficacy and toxicity, and challenges that exist between pharmacogenomic discovery and translation into clinical use.

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Genetic Polymorphisms of Drug-Metabolizing Enzymes and Anti-TB Drug-Induced Hepatitis

Cited by 66 publications

References 36 publications

Epidemiology and risk factors for drug allergy

Epidemiology and risk factors for drug allergy

Genetic and ethnic risk factors associated with drug hypersensitivity

Pharmacogenomics of Antimicrobial Agents

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