Genetic Polymorphisms of Cytochromes P450 in Finno-Permic Populations of Russia

Abstract

Cytochrome P450 is an enzyme involved in the metabolism of phase 1 xenobiotics, toxins, endogenous hormones, and drugs, including those used in COVID-19 treatment. Cytochrome p450 genes are linked to the pathogenesis of some multifactorial traits and diseases, such as cancer, particularly prostate cancer, colorectal cancer, breast cancer, and cervical cancer. Genotyping was performed on 540 supposedly healthy individuals of 5 Finno-Permic populations from the territories of the European part of the Russian Federation. There was a statistically significant difference between Veps and most of the studied populations in the rs4986774 locus of the CYP2D6 gene; data on the rs3892097 locus of the CYP2D6 gene shows that Izhemsky Komis are different from the Mordovian and Udmurt populations.

Effect of CADM1 on TPF-induced chemotherapy in laryngeal squamous cell carcinoma

“… 16 – 18 Cytochrome P450 is an enzyme involved in the metabolism of phase 1 xenobiotics, toxins, and cancer drugs that can affect carcinogenesis, treatment outcomes, and cancer drug resistance. 19 , 20 Chockley et al. found that epithelial-mesenchymal transition (EMT)-induced modulation of E-cadherin levels and CADM1 overexpression could mediate increased tumor susceptibility to NK cytotoxicity, leading to inefficient metastasis.…”