Genetic polymorphisms of alcohol-metabolizing enzymes and their association with alcoholism risk, personality and anthropometric traits among Malaysian university students

Ong, Hing-Huat; Khor, Foong-Vai; Balasupramaniam, Kausalyah; Say, Yee‐How

doi:10.1080/13548506.2017.1338737

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…The μ-opioid receptor (MOR) is a specific type of G-protein-coupled receptor that has a significant impact on reward and pleasure processes and has been associated with addictive behaviour [ 33 ]. This receptor has been found in the mesolimbic dopaminergic system of animal models, including in structures such as the basal ganglia and ventral tegmental area [ 34 , 35 ]. There is evidence suggesting that alcohol causes the release of endogenous opioids in the brain and indirectly activates opioid signalling pathways and that the rewarding effects and positive reinforcement experienced after alcohol consumption are regulated by opioid receptors [ 2 , 9 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that openness to experience is associated with certain genotypes and alleles of ADH1C and ALDH2 [ 35 ], but there have been no data about the correlation between the OPRM1 gene and personality traits up to now. Our data presented above are the first to prove that openness to experience may be related to OPRM1 gene polymorphisms.…”

Section: Discussionmentioning

confidence: 99%

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OPRM1 Gene Polymorphism in Women with Alcohol Use Disorder

Boroń,

Suchanecka,

Chmielowiec

et al. 2024

IJMS

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The main aims of the present study were to explore the relationship of the OPRM1 gene rs1074287 polymorphism in alcohol-dependent women with their personality traits and to try to find out whether any specific features may influence alcohol cravings and be a prognostic for alcohol dependency and treatment in AUD women. Our study found a notable correlation between openness and the interaction of the ORIM1 gene and AUD. The alcohol use disorder subjects with genotype AG showed a higher level of openness compared to the control group with genotypes AG (p = 0.0001) and AA (p = 0.0125). The alcohol use disorder subjects with the AA genotype displayed higher levels of openness than the control group with genotype AG (p = 0.0271). However, the alcohol use disorder subjects with the AA genotype displayed lower levels of openness than the control group with genotype GG (p = 0.0212). Our study indicates that openness as a personality trait is correlated with the OPRM1 gene rs1074287 polymorphism in alcohol-dependent women. These are the first data and results exploring such a relationship between opioid and alcohol pathways and the mental construction of AUD women. Personality traits such as openness to experience and neuroticism might play major roles in the addiction mechanism, especially in genetically predisposed females, independent of the reward system involved in the emotional disturbances that coexist with anxiety and depression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

OPRM1 Gene Polymorphism in Women with Alcohol Use Disorder

Boroń,

Suchanecka,

Chmielowiec

et al. 2024

IJMS

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“…Variation in metabolism rate, compulsive alcohol use, altered behavior, and deleterious effects has been attributed to Single Nucleotide Polymorphisms (SNPs) occurrence in alcohol metabolizing genes in PAE fetuses and alcohol users (Ong et al, 2018;Katsarou et al, 2017). Non-synonymous SNPs (nsSNPs) comprise a group of SNPs that, together with SNPs in regulatory regions, are believed to have the highest impact on phenotype (Abid et al, 2023;Robert and Pelletier, 2018).…”

Section: Introductionmentioning

confidence: 99%

Alcohol Intubation and Synergistic Effect of Folic Acid and Egg Yolk Powder Solution on Alcohol Dehydrogenase [ADH] Class I Gene Expression and Single Nucleotide Polymorphism Frequency in Parent and Prenatal Alcohol Exposed Wistar Rats

Obajuluwa,

Iyiola,

Morakinyo

et al. 2024

OnLine Journal of Biological Sciences

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Point mutation detections in alcohol metabolizing genes could unravel molecular targets of gestational alcohol and epigenetic remodeling capacity of maternal nutrition, which underscores growth and health endpoints in Prenatal Alcohol Exposed (PAE) fetuses. gene expression was assayed using sequenced target and internal control gene primers in a twostep thermal cycling process from isolated RNA in purely bred alcohol male and female Norway rats weighing between 200-220 g. They were mated and grouped as follows: (A) Distilled water only [negative control)., (B) Local gin only, (C) Local gin supplemented with egg yolk solution, (D) Local gin supplemented with egg yolk solution and folic acid (E) EtOH only (positive control). Equal doses of 3.0 mL/kg/bw were administered before, during, and after gestation via oral gavage. ADHI gene subtypes in the pups of mated rats were analyzed by the methods used in the parental stocks. The PCR products were electrophoresed on a 2.5% agarose gel while bioinformatics databases for SNP detection were used for the sequenced data analyses in the alcohol-dosed parent and PAE rats. a total number of 35,838 bp coding DNA of the ADH1 gene were sequenced in the experimental rats with 115 random synonymous and non-synonymous SNP distributions. Parent-of-origin inheritance pattern of ADHI was confirmed in PAE neonates while SNPs frequency in sequence data of ADHI subtypes in groups' B-E dicts functional alcohol effects and changes in resultant protein. Hence, this study provides evidence for paternal and maternal contributions and nutrient-gene interactions in PAE rats.

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