Genetic polymorphisms in Toll-like receptor 3 gene are associated with the risk of hepatitis B virus-related liver diseases in a Chinese population

Huang, Xiamei; Li, Haiwei; Wang, Jian; Huang, Chuan; Yu, Lu; Qin, Xue; Li, Shan

doi:10.1016/j.gene.2015.05.054

Cited by 32 publications

(30 citation statements)

References 43 publications

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“…We found TLR3 À7C/A A allele frequency was 17.5% in controls in this study, in Japan population it was reported to be 22.6% in controls [Ishizaki et al, 2008]; 18% in African-American population, 13% in Caucasian population, and 23% in Chinese population [Cheng et al, 2007]. While in our study the TLR3 c.1377 TT genotype frequency was 4.7% in controls, it was reported to be 8% in an other Turkish population study [Etem et al, 2011]; 3.6% in North Indian population [Mandal et al, 2012], 18.3% in Chinese population [Huang et al, 2015]. The frequency of the TLR3 c.1377 TT genotype, (homozygous mutant genotype), in CCHF patients was significantly higher than that of the controls, in this study.…”

Section: Discussioncontrasting

confidence: 65%

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Is there any relationship between Toll‐like receptor 3 c.1377C/T and −7C/A polymorphisms and susceptibility to Crimean Congo hemorrhagic fever?

Engin

Arslan

Özbilüm

et al. 2016

Journal of Medical Virology

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Crimean-Congo hemorrhagic fever (CCHF) is an infectious disease that is caused by CCHF virus. A family of transmembrane receptors called as Toll-like receptors (TLRs) selectively acts in recognizing a wide range of microbial components and endogenous molecules released by damaged tissue and have been preserved throughout evolution. TLRs initiate some signaling cascades which activate the innate immune system. Mainly four TLRs act in protection against viral infections; TLR3 is one of them. TLR3 identifies dsRNA. By producing inflammatory cytokines and type I interferons, it generates an antiviral immune response. Proper response to TLR ligands may be impaired by single nucleotide polymorphisms (SNPs) within TLR genes in some indviduals, and this can cause varied susceptibility to infections. In the present work, polymerase chain reaction-based restriction fragment length polymorphism is used to analyze the frequencies of TLR3 (c.1377C/T and -7C/A) polymorphisms in 149 CCHF patients and 171 healthy adults as controls, in Cumhuriyet University, Sivas/Turkey. We also investigated the relation between these polymorphisms and severity or mortality of CCHF disease. This is the first study investigating the TLR3 SNPs in patients with CCHF. In the present study, the frequency of the TLR3 (c.1377C/T and -7A/C) genotypes in fatal and non-fatal cases were comparable, however, the homozygous mutant (TT) genotype frequency of TLR3 c.1377C/T in CCHF patients was significantly higher than that of the healthy controls. In conclusion, presence of TLR3 c.1377 TT genotype may have a role in the susceptibility to CCHF. J. Med. Virol. 88:1690-1696, 2016. © 2016 Wiley Periodicals, Inc.

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Section: Discussioncontrasting

confidence: 65%

“…A study carried out by Huang et al [] revealed a lower TT genotype of TLR3 rs3775290 frequency in patients with chronic hepatitis B than in healthy controls. They also reported that the subjects carrying the TT genotype had a decreased risk for hepatocellular carcinoma compared with the subjects carrying the CC genotype.…”

Section: Discussionmentioning

confidence: 99%

Is there any relationship between Toll‐like receptor 3 c.1377C/T and −7C/A polymorphisms and susceptibility to Crimean Congo hemorrhagic fever?

Engin

Arslan

Özbilüm

et al. 2016

Journal of Medical Virology

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“…However, several studies have suggested that TLR3 may contribute to resistance against HCV infection, even though TLR3 appears to have no role in disease advancement after a chronic infection is established [16, 40]. TLR3 polymorphisms (rs1879026 and rs3775290) have been described to be associated with a risk for HBV-related liver diseases in a Chinese population [41], whereas the same nine SNPs of our study were not correlated with any susceptibility to HBV-related liver diseases in the Saudi Arabian population [15]. Therefore, the impact of TLR3 polymorphisms may act in an ethnic- and viral-specific manner.…”

Section: Discussionmentioning

confidence: 99%

Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection

Al-Anazi

Matou‐Nasri

Abdo

et al. 2017

Journal of Immunology Research

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Toll-like receptor 3 (TLR3) plays a key role in innate immunity by recognizing pathogenic, double-stranded RNAs. Thus, activation of TLR3 is a major factor in antiviral defense and tumor eradication. Although downregulation of TLR3 gene expression has been mainly reported in patients infected with hepatitis C virus (HCV), the influence of TLR3 genotype on the risk of HCV infection, HCV-related cirrhosis, and/or hepatocellular carcinoma (HCC) remains to be determined. Single-nucleotide polymorphisms (SNPs) within the TLR3 gene and their associations with HCV-related disease risk were investigated in a Saudi Arabian population in this study. Eight TLR3 SNPs were analyzed in 563 patients with HCV, which consisted of 437 patients with chronic HCV infections, 88 with HCV-induced liver cirrhosis, and 38 with HCC. A total of 599 healthy control subjects were recruited to the study. Among the eight TLR3 SNPs studied, the rs78726532 SNP was strongly associated with HCV infection when compared to that in healthy control subjects. The rs5743314 was also strongly associated with HCV-related liver disease progression (cirrhosis and HCC). In summary, these results indicate that distinct genetic variants of TLR3 SNPs are associated with HCV infection and HCV-mediated liver disease progression in the Saudi Arabian population.

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“…HSC also undergo transformation into myofibroblasts, leading to increased production of extracellular matrix proteins; this process is a host-protective response, but causes scarring and liver fibrosis when dysregulated [79]. As noted above, TLR3 signalling has been implicated in host responses during HBV infection [40][41][42]. However, growing evidence suggests that TLR3 also contributes to the inactivation or death of activated HSC and Kupffer cells during liver injury, contributing to protective responses against liver damage [80] and fibrosis [81,82].…”

Section: Livermentioning

confidence: 99%

“…Tlr3 -/-mice displayed enhanced replication of HSV-1 in the CNS [38], and an increased susceptibility to HSV-2 infection in the CNS after vaginal inoculation [39]. In humans, TLR3 polymorphisms (C1234T, rs1879026 G/T) have also been linked to increased risk to chronic hepatitis B virus (HBV) infection and HBV-induced hepatocellular carcinoma [40,41], while the C13766T TLR3 polymorphism was suggested to be protective against HBV infection and HBV-related liver disease [42]. A study analysing Saudi Arabian patients with HBV infections reported a TLR3 single nucleotide polymorphism (rs1879026 G/T) that was found more frequently in HBV-infected patients [40].…”

Section: Role Of Tlr3 In Host Defencementioning

confidence: 99%

The toll-like receptor 3 pathway in homeostasis, responses to injury and wound repair

Ramnath

Powell

Scholz

et al. 2017

Seminars in Cell & Developmental Biology

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In addition to their established roles in host defence, Tolllike Receptors (TLRs) have emerging roles in control of homeostasis, injury and wound repair. The dsRNA-sensing receptor, TLR3, has been particularly implicated in such processes in several different tissues including the skin, intestine and liver, as well as in the control of reparative mechanisms in the brain, heart and kidneys, following ischemia reperfusion injury. In this review, we provide an overview of TLR3 signalling and functions in inflammation, tissue damage and repair processes, as well as therapeutic opportunities that may arise in the future from knowledge of such pathways.

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Genetic polymorphisms in Toll-like receptor 3 gene are associated with the risk of hepatitis B virus-related liver diseases in a Chinese population

Cited by 32 publications

References 43 publications

Is there any relationship between Toll‐like receptor 3 c.1377C/T and −7C/A polymorphisms and susceptibility to Crimean Congo hemorrhagic fever?

Is there any relationship between Toll‐like receptor 3 c.1377C/T and −7C/A polymorphisms and susceptibility to Crimean Congo hemorrhagic fever?

Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection

The toll-like receptor 3 pathway in homeostasis, responses to injury and wound repair

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