Genetic polymorphisms in TNFA/TNFR2 genes and Chagas disease in a Colombian endemic population

Criado, Libeth; Flórez, Óscar; Martı́n, Javier; González, Clara Isabel

doi:10.1016/j.cyto.2011.12.007

Cited by 19 publications

(13 citation statements)

References 55 publications

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“…In the acute phase of infection, IFN-γ acts in concert with TNF-α to induce macrophage activation, and consequently NO production to eliminate the parasite [22,23]. In present study, the CHD, group had significantly higher TNF-α levels than the NI group at T12, which is consistent with other studies that reported high levels of TNF-α in patients with Chagas disease compared with healthy individuals [24]. The increase in TNF-α levels is related to the evolution of Chagas disease from the asymptomatic form to the symptomatic form, and is associated with the course and severity of chronic Chagas heart disease, suggesting its involvement in the formation of chronic inflammation and cardiac lesions [24].…”

Section: Discussionsupporting

confidence: 82%

Physical training improves cardiopulmonary functional capacity and increases cytokine IL-10 levels in individuals with Chagas disease

Lopes¹,

Ferreira²,

Silva³

et al. 2017

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 82%

Physical training improves cardiopulmonary functional capacity and increases cytokine IL-10 levels in individuals with Chagas disease

Lopes¹,

Ferreira²,

Silva³

et al. 2017

Trop. J. Pharm Res

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“…Our group has studied several polymorphisms in Colombian and Peruvian samples in which we found associations with several cytokine genes, especially IL1B, IL12B, MIF, TGFB and IFNG, and cytokine receptor genes such as CCR2 and CCR5. [13][14][15][16][17][18][19][20][21][22] Cytokine IL-17A, which is encoded by the IL17A gene located on chromosome 6, is involved in the development of inflammation and host defense against infection by inducing the expression of genes encoding proinflammatory cytokines and chemokines. 23 In Chagas disease, IL-17A has been studied in mouse models and human samples and was shown to control parasitemia levels in mice inoculated with Trypanosoma cruzi and to have an important role in modulating the production of IFN-γ and TNF-α, thereby reducing heart damage.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the role of IL17A gene variants in Chagas disease

et al. 2015

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Human host genetic factors have been suggested to be determinants of the prevalence and clinical forms of Chagas disease. In this regard, IL-17A is believed to control parasitemia and protect against heart disease. In this work, we assessed whether IL17A gene polymorphisms are related to infection and/or development of the cardiac form of Chagas disease by genotyping for five IL17A SNPs (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909) in 1171 individuals from a Colombian region endemic for Chagas disease, classified as seronegative (n=595), seropositive asymptomatic (n=175) and chronic Chagas cardiomyopathy (n=401). Our results showed that SNP rs8193036, which is located upstream of the coding region of the gene, was slightly associated with protection against T. cruzi infection (P=0.0170, P(FDR)=0.0851, odds ratio (OR)=0.80, confidence interval (CI)=0.66-0.96) and associated with protection against the development of cardiomyopathy (P=0.0065, P(FDR)=0.0324, OR=0.75, CI=0.60-0.92). This finding suggests that this IL17A polymorphism could be associated with Trypanosoma cruzi infection and the development of chronic cardiomyopathy due to differential expression of cytokine IL-17A.

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“…Considering that cytokines, chemokine, and immunomodulatory molecules play an important role in the pathogenesis of many diseases, including Chagas disease, and gene polymorphisms may influence the expression of these molecules, different studies have reported the association between different clinical forms of Chagas disease and polymorphisms at TNF [ 57 – 61 ], IL-1β [ 62 ], IL-10 [ 63 ], IL-4 [ 64 ], INF-γ [ 65 ], TGF-β1 [ 66 ], IL-12B [ 67 ], CXCL9 [ 68 ], CXCL10 [ 68 ], CCR5 [ 68 – 70 ], CCL2 [ 71 ], and CTLA-4 [ 25 ] genes.…”

Section: Discussionmentioning

confidence: 99%

Human Leucocyte Antigen‐G (HLA‐G) and Its Murine Functional Homolog Qa2 in the Trypanosoma cruzi Infection

Dias

Mendes-Junior

Silva

et al. 2015

Mediators of Inflammation

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Genetic susceptibility factors, parasite strain, and an adequate modulation of the immune system seem to be crucial for disease progression after Trypanosoma cruzi infection. HLA-G and its murine functional homolog Qa2 have well-recognized immunomodulatory properties. We evaluated the HLA-G 3′ untranslated region (3′UTR) polymorphic sites (associated with mRNA stability and target for microRNA binding) and HLA-G tissue expression (heart, colon, and esophagus) in patients presenting Chagas disease, stratified according to the major clinical variants. Further, we investigated the transcriptional levels of Qa2 and other pro- and anti-inflammatory genes in affected mouse tissues during T. cruzi experimental acute and early chronic infection induced by the CL strain. Chagas disease patients exhibited differential HLA-G 3′UTR susceptibility allele/genotype/haplotype patterns, according to the major clinical variant (digestive/cardiac/mixed/indeterminate). HLA-G constitutive expression on cardiac muscle and colonic cells was decreased in Chagasic tissues; however, no difference was observed for Chagasic and non-Chagasic esophagus tissues. The transcriptional levels of Qa2 and other anti and proinflammatory (CTLA-4, PDCD1, IL-10, INF-γ, and NOS-2) genes were induced only during the acute T. cruzi infection in BALB/c and C57BL/6 mice. We present several lines of evidence indicating the role of immunomodulatory genes and molecules in human and experimental T. cruzi infection.

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Genetic polymorphisms in TNFA/TNFR2 genes and Chagas disease in a Colombian endemic population

Cited by 19 publications

References 55 publications

Physical training improves cardiopulmonary functional capacity and increases cytokine IL-10 levels in individuals with Chagas disease

Physical training improves cardiopulmonary functional capacity and increases cytokine IL-10 levels in individuals with Chagas disease

Investigation of the role of IL17A gene variants in Chagas disease

Human Leucocyte Antigen‐G (HLA‐G) and Its Murine Functional Homolog Qa2 in the Trypanosoma cruzi Infection

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