Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender‐specific manner (the SELGEN study)

Méplan, Catherine; Crosley, Lynne K.; Nicol, Fergus; Beckett, Geoffrey J.; Howie, A F; Hill, Kristina E.; Horgan, Graham; Mathers, John C.; Arthur, John R.; Hesketh, John E.

doi:10.1096/fj.07-8166com

Cited by 180 publications

(208 citation statements)

References 34 publications

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“…Our result is in opposition with most European surveys (Arnaud et al, 2006;Meplan et al, 2007;Ortega et al, 2012) or US populations (Bleys et al, 2009), in which obese patients have lower serum selenium concentration, but in agreement with Dewailly's survey of a French Polynesian sampling in which selenium concentration in blood was positively linked to BMI , the regression coefficient (β) being 0.02, i.e. ten times higher than in our study, among the controls (β=0.002).…”

Section: Discussioncontrasting

confidence: 62%

Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

Ren

Kitahara²,

González³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Numerous studies have suggested that selenium deficiency may be associated with an increased risk for several types of cancer, but few have focused on thyroid cancer. Materials and Methods: We examined the association between post-diagnostic fingernail selenium levels and differentiated thyroid cancer risk in a French Polynesian matched case-control study. Conditional logistic regression models were used to estimate odds ratios and 95% confidence intervals. Results: The median selenium concentration among controls was 0.76 μg/g. Significantly, we found no association between fingernail selenium levels and thyroid cancer risk after conditioning on year of birth and sex and additionally adjusting for date of birth (highest versus lowest quartile: odds-ratio=1.12, 95% confidence interval: 0.66-1.90; p-trend=0.30). After additional adjustment for other covariates, this association remained non-significant (p-trend=0.60). When restricting the analysis to thyroid cancer of 10 mm or more, selenium in nails was non-significantly positively linked to thyroid cancer risk (p-trend=0.09). Although no significant interaction was evidenced between iodine in nails and selenium in nails effect (p=0.70), a non-significant (p-trend =0.10) positive association between selenium and thyroid cancer risk was seen in patients with less than 3 ppm of iodine in nails. The highest fingernail selenium concentration in French Polynesia was in the Marquises Islands (M=0.87 μg/g) and in the Tuamotu-Gambier Archipelago (M=0.86 μg/g). Conclusions: Our results do not support, among individuals with sufficient levels of selenium, that greater long-term exposure to selenium may reduce thyroid cancer risk. Because these findings are based on post-diagnostic measures, studies with prediagnostic selenium are needed for corroboration.

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Section: Discussioncontrasting

confidence: 62%

Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

Ren

Kitahara²,

González³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Dietary intervention studies in which genotyping of several genes and assessment of phenotypic response is built into the study protocol at the outset, can provide valuable information [38,40,44]. However, these studies are often too small, or may be subject to statistical bias because of different numbers of participants in genotypic sub-groups or are conducted amongst high-risk individuals, which are not representative of the genetic heterogeneity within the overall population [41].…”

Section: Genetic Variation and Nutritionmentioning

confidence: 99%

“…However, these studies are often too small, or may be subject to statistical bias because of different numbers of participants in genotypic sub-groups or are conducted amongst high-risk individuals, which are not representative of the genetic heterogeneity within the overall population [41]. There are very few dietary intervention studies in which individuals are recruited prospectively in order to study specific diet-genotype interactions [15,40]. However, a number of studies are expected to report in the near future, including a prospective study of the impact of apo E genotype on blood lipid responses to fish oil fatty acids, which has also been designed to include equal numbers of both genders in each genotypic sub-group [44].…”

Section: Genetic Variation and Nutritionmentioning

confidence: 99%

The challenges for molecular nutrition research 1: linking genotype to healthy nutrition

Williams¹,

Ordovas

Lairon

et al. 2008

Genes Nutr

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Nutrition science finds itself at a major crossroad. On the one hand we can continue the current path, which has resulted in some substantial advances, but also many conflicting messages which impair the trust of the general population, especially those who are motivated to improve their health through diet. The other road is uncharted and is being built over the many exciting new developments in life sciences. This new era of nutrition recognizes the complex relation between the health of the individual, its genome, and the life-long dietary exposure, and has lead to the realisation that nutrition is essentially a gene-environment interaction science. This review on the relation between genotype, diet and health is the first of a series dealing with the major challenges in molecular nutrition, analyzing the foundations of nutrition research. With the unravelling of the human genome and the linking of its variability to a multitude of phenotypes from ''healthy'' to an enormously complex range of predispositions, the dietary modulation of these propensities has become an area of active research. Classical genetic approaches applied so far in medical genetics have steered away from incorporating dietary effects in their models and paradoxically, most genetic studies analyzing diet-associated phenotypes and diseases simply ignore diet. Yet, a modest but increasing number of studies are accounting for diet as a modulator of genetic associations. These range from observational cohorts to intervention studies with prospectively selected genotypes. New statistical and All authors are member of The European Nutrigenomics Organisation (http://www.nugo.org). bioinformatics approaches are becoming available to aid in design and evaluation of these studies. This review discusses the various approaches used and provides concrete recommendations for future research. C. M. Williams (&)Hugh

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“…For example, rs1050450 causes a Pro-Leu amino acid change in glutathione peroxidise 1 and affects protein function [12], rs713041 causes a T-C substitution in a region of the glutathione peroxidise 4 (GPX4) gene corresponding to the 3 0 UTR of the mRNA and alters the protein binding to the 3 0 UTR and reporter gene activity [3,21], rs5859 and rs5845 in the 3 0 UTR of the 15-kDa selenoprotein affect reporter gene activity [13] and rs7579 and rs3877899 in the SEPP1 gene affect biomarkers of selenoprotein status in vivo [20]. Variants in the promoter of SELS are functional in that they modulate SelS expression and plasma levels of inflammatory cytokines [10].…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer

et al. 2010

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Selenium (Se), a dietary trace metal essential for human health, is incorporated into *25 selenoproteins including selenoprotein S (SelS) and the 15-kDa selenoprotein (Sep15) both of which have functions in the endoplasmic reticulum protein unfolding response. The aim of this study was to investigate whether genetic variants in such selenoprotein genes are associated with altered risk of colorectal cancer (CRC). A Korean population of 827 patients with CRC and 733 healthy controls was genotyped for 7 SNPs in selenoprotein genes and one SNP in the gene encoding manganese superoxide dismutase using Sequenom technology. Multivariate logistic regression analysis showed that after adjustment for lifestyle factors three SNP variants were associated with altered disease risk. There was a mean odds ratio of 2.25 [95% CI 1.13,4.48] in females homozygous TT for rs34713741 in SELS with the T variant being associated with higher risk of rectal cancer, and odds ratios of 2.47 and 2.51, respectively, for rs5845 and rs5859 in SEP15 with the minor A and T alleles being associated with increased risk of male rectal cancer. The data indicate that the minor alleles for rs5845, rs5859 and rs34713741 are associated with increased rectal cancer risk and that the effects of the three SNPs are dependent on gender. The results highlight potential links between Se, the function of two selenoproteins involved in the protein unfolding response and CRC risk. Further studies are required to investigate whether the effects of the variants on CRC risk are also modulated by dietary Se intake.

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Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender‐specific manner (the SELGEN study)

Cited by 180 publications

References 34 publications

Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

The challenges for molecular nutrition research 1: linking genotype to healthy nutrition

Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer

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