Genetic Polymorphisms in Sepsis and Cardiovascular Disease

Nakada, Taka‐aki; Takahashi, Waka; Nakada, Emiri; Shimada, Tadanaga; Russell, James A.; Walley, Keith R.

doi:10.1016/j.chest.2019.01.003

Cited by 18 publications

(6 citation statements)

References 76 publications

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“…To note, we found that among patients with higher NETosis markers, carriers of T allele were 3-fold more frequent than CC patients. The concept of sepsis and cardiovascular diseases sharing a common pathophysiology has been recently explored 45 . Common gene signaling pathways for both sepsis and cardiovascular diseases were explored and genetic variations in miR-146a targets such as IL6 or IRAK1, were shared in patients with both diseases 45 .…”

Section: Discussionmentioning

confidence: 99%

“…The concept of sepsis and cardiovascular diseases sharing a common pathophysiology has been recently explored 45 . Common gene signaling pathways for both sepsis and cardiovascular diseases were explored and genetic variations in miR-146a targets such as IL6 or IRAK1, were shared in patients with both diseases 45 . Although sepsis and cardiovascular disease etiology is not identical, they share the same end-points of inflammation, coagulation, and endothelial activation 46,47 .…”

Section: Discussionmentioning

confidence: 99%

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miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis

et al. 2020

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“…In a genome-wide association study, the CD14 locus was shown to be associated with CV disease [ 37 ]. In particular, the SNP rs2569190 was related to the occurrence of CV diseases in case-control studies as well as meta-analysis [ 16 , 38 , 39 ]. In meta-analyses, the TT genotype and T allele of rs2569190 have been associated with ischemic heart diseases [ 38 ] and the susceptibility and development of cardiovascular disease [ 16 ], particularly in the East Asian population but not European population.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

Schulz

Zielske

Schneider

et al. 2021

Mediators of Inflammation

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Background. The biological link between severe periodontitis and cardiovascular disease is well established. Both complex inflammatory diseases are influenced by genetic background. Therefore, the impact of genetic variations of receptors of the innate immune system—(Toll-like receptors (TLRs)) TLR2, TLR4, cluster of differentiation 14 (CD14), and the transcription factor nuclear factor-κΒ (NF-κB)—was investigated. Materials and Methods. In this study (ClinicalTrials.gov identifier: NCT01045070), 1002 cardiovascular (CV) patients were included. In a 3-year follow-up period, new vascular events were assessed. SNPs in CD14 (rs2569190), NF-κΒ (rs28362491), TLR2 (rs5743708), and TLR4 (rs4986790) were genotyped. The impact of these genetic variants on severe periodontitis as well as on CV outcome was assessed. Results. All investigated genetic variants were not associated with preexisting CV events or severe periodontitis in CV patients. In Kaplan-Meier survival analyses, the CT genotype of CD14 single-nucleotide polymorphism (SNP) rs2569190 was shown to be an independent predictor for combined CV endpoint (log rank: p = 0.035 ; cox regression; hazard ratio: 1.572; p = 0.044 ) as well as cardiovascular death (log rank: p = 0.019 ; cox regression; hazard ratio: 1.585; p = 0.040 ) after three years of follow-up. Conclusions. SNPs in CD14, NF-κΒ, TLR2, and TLR4 are no risk modulators for preexisting CV events or severe periodontitis in CV patients. The CT genotype of CD14 SNP rs2569190 provides prognostic value for further CV events within 3 years of follow-up.

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“…Many of these studies have been conducted in populations of a specific ethnic origin, so their relevance has a local or geographical character, depending on the size and characteristics of the population included in the study. Several studies analyze the association of gene polymorphisms with cardiovascular disease in the Caucasian population [25][26][27] . These and many other studies show that the presence of polymorphic variants in numerous genes involved in cardiovascular regulation may favor the risk or predisposition to a broad spectrum of cardiovascular disorders.…”

Section: Discussionmentioning

confidence: 99%

Association of Alk1 and Endoglin Polymorphisms with Cardiovascular Damage

Garzon-Martinez

Perretta-Tejedor

Gómez‐Marcos

et al. 2020

Sci Rep

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Cardiovascular diseases are associated to risk factors as obesity, hypertension and diabetes. The transforming growth factor-β1 receptors ALK1 and endoglin regulate blood pressure and vascular homeostasis. However, no studies relate the association of ALK1 and endoglin polymorphisms with cardiovascular risk factors. We analysed the predictive value of the ALK1 and endoglin polymorphisms on cardiovascular target organ damage in hypertensive and diabetic patients in 379 subjects with or without hypertension and diabetes in a Primary Care setting. The ALK1 rs2071219 polymorphism (AA genotype) is associated with a lower presence of diabetic retinopathy and with the absence of altered basal glycaemia. Being carrier of the ALK1 rs3847859 polymorphism (G allele) is associated with lower basal heart rate and with higher LDL-cholesterol levels. The endoglin rs3739817 polymorphism (AA genotype) is associated with higher levels of LDL-cholesterol, and being carrier of the endoglin rs10987759 polymorphism (C allele) is associated with higher haemoglobin levels and with an increased heart rate. Summarizing, several ALK1 and endoglin gene polymorphisms increase the risk of cardiovascular events. The analysis of these polymorphisms in populations at risk, in combination with the determination of other parameters and biomarkers, could implement the diagnosis and prognosis of susceptibility to cardiovascular damage.

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Genetic Polymorphisms in Sepsis and Cardiovascular Disease

Cited by 18 publications

References 76 publications

miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis

miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis

Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

Association of Alk1 and Endoglin Polymorphisms with Cardiovascular Damage

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