Genetic polymorphisms in oxidative stress‐related genes are associated with outcomes following treatment for aggressive B‐cell non‐Hodgkin lymphoma

Gustafson, Heather L.; Yao, Song; Goldman, Bryan; Lee, Kristy; Spier, Catherine M.; LeBlanc, Michael; Rimsza, Lisa M.; Cerhan, James R.; Habermann, Thomas M.; Link, Brian K.; Maurer, Mathew S.; Slager, Susan L.; Persky, Daniel O.; Miller, Thomas P.; Fisher, Richard I.; Ambrosone, Christine B.; Briehl, Margaret M.

doi:10.1002/ajh.23709

Cited by 26 publications

(20 citation statements)

References 47 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gustafson came to a similar conclusion. He proved that rs1883112 is the representative of nearby SNP, which has a functional effect on NADPH oxidase activity (Gustafson et al, 2014). As with rs4673, the effect of this polymorphism in HBV-induced liver disease was unknown prior to the current study.…”

Section: Discussionmentioning

confidence: 82%

“…We found that the rs1883112G allele was more frequent in healthy controls than the CIB group and thus had a protective effect. The protective effect of the variant G allele has been demonstrated in other diseases, and is related to higher rate of disease-free survival in diffuse large B-cell lymphoma (DLBCL) (Rossi et al, 2009) and aggressive B-cell non-Hodgkin's lymphoma (NHL) (Gustafson et al, 2014). For acute myeloid leukemia (AML) patients, the rs1883112 variant G allele is related to higher frequency of complete remission (Megias-Vericat et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oxidative Stress-Related Gene Polymorphisms Are Associated With Hepatitis B Virus-Induced Liver Disease in the Northern Chinese Han Population

Liu

Zhang

et al. 2020

Front. Genet.

View full text Add to dashboard Cite

Oxidative stress is closely related to the occurrence and development of various diseases such as cancer, diabetes, and cardiovascular and infectious diseases. We identified six critical genetic variants related to oxidative stress, and evaluated their main effects and their interaction effects on hepatitis B virus (HBV)-induced liver diseases. We enrolled 3,128 Han Chinese subjects into five groups: healthy controls, chronic hepatitis B (CHB), liver cirrhosis (LC), hepatocellular carcinoma (HCC), and natural clearance. We then determined the genotypes in each group for CYBA-rs4673, NCF4-rs1883112, NOX4-rs1836882, rs3017887, SOD2-rs4880, and GCLM-rs41303970, and evaluated the association between these variants and HBV-induced liver diseases. Gene-gene interactions were evaluated using generalized multifactor dimensionality reduction, logistic regression, and four-by-two tables. Significant associations were observed between healthy controls and the CIB group (CHB+LC+HCC). The CYBA-rs4673AG genotype was associated with a 1.356 rate of susceptibility of HBV-induced liver disease compared to the wild type GG genotype. The NCF4-rs1883112G allele occurred more frequently in healthy controls than in the CIB group in all three models (dominant, codominant, and recessive). Nox4-rs1836882 TC showed a protective association, being more frequent in healthy controls compared to the wild type TT genotype. GCLM-rs41303970A was associated with HBV-induced liver disease. The overall best model by multifactor dimensionality reduction was a five factor interaction model that had the highest cross validation consistency (10/10) and test accuracy (0.5669), P = 0.001. Oxidative stress-related gene polymorphisms are likely to be associated with HBV-induced liver disease, suggesting that information on these variations is useful for risk assessment of HBV-induced liver disease.

show abstract

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Oxidative Stress-Related Gene Polymorphisms Are Associated With Hepatitis B Virus-Induced Liver Disease in the Northern Chinese Han Population

Liu

Zhang

et al. 2020

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…Remarkably, in our study we demonstrated a highly significant association between the IL2 SNP (rs2069762) and the onset of treatment‐related skin rash, a well‐known and frequent adverse event of bendamustine. To our knowledge, only a few reports, focused on aggressive NHL receiving R‐CHOP, observed a correlation between SNPs and treatment toxicity (Gustafson et al , ; Jordheim et al , ).…”

Section: Discussionmentioning

confidence: 99%

Study of gene polymorphisms as predictors of treatment efficacy and toxicity in patients with indolent non‐hodgkin lymphomas and mantle cell lymphoma receiving bendamustine and rituximab

et al. 2018

View full text Add to dashboard Cite

Bendamustine is used in combination with rituximab (BR) to treat indolent non-Hodgkin lymphomas (iNHL) and mantle cell lymphoma (MCL). The variability in treatment efficacy and toxicity could be related to single nucleotide polymorphisms (SNPs) in immune response genes. We would like to show a correlation between SNPs and treatment outcome in iNHL and MCL patients receiving BR. We investigated some SNPs that had already been associated with NHL outcome. Samples were genotyped for the IL2 (rs2069762), IL10 (rs1800890, rs10494879), VEGFA (rs3025039), IL8 (rs4073), CFH (rs1065489) and MTHFR (rs1801131) SNPs by allelic discrimination assays. We enrolled 70 patients that received rituximab 375 mg/m and bendamustine 90 mg/m every 28 days, both as first-line treatment and ≥ second-line regimens. Overall response rate was 97·1% (complete response [CR] rate 73·9%). Treatment toxicity included grade 3-4 neutropenia (24/70 patients), infections (21/70 patients; 1/70 grade 3), skin rash (26/70 patients; 2/70 grade 3). After a median follow-up of 24 months we did find any correlation between the analysed SNPs, CR rate and PFS. However, we demonstrated an association between the SNP in IL2 (rs2069762) and the onset of skin rash (P = 0·0001). Our study suggests a role for cytokine SNPs in bendamustine-related toxicity, which could represent a promising research field.

show abstract

“…Polymorphisms in AKR1C3 were studied as the risk factors for lung, prostate 60 , lymphoma 61 and bladder cancer 62 . There are also reports regarding the role of AKR1C3 variation in the risk of disease progression and mortality in B cell non-Hodgkin lymphoma 63 , as well as in the modulation of treatment toxicity and survival time in breast cancer patients 58 . However, the influence of rs3209896 polymorphism on cancer risk and chemotherapy response was considered only in two previous studies, but with no success.…”

Section: Discussionmentioning

confidence: 99%

Genetic 3′UTR variations and clinical factors significantly contribute to survival prediction and clinical response in breast cancer patients

Pamuła‐Piłat

Tęcza

Kalinowska-Herok

et al. 2020

Sci Rep

View full text Add to dashboard Cite

The study describes a relationship between the 3′UTR variants, clinicopathological parameters and response to chemotherapy. We analyzed 33 germline polymorphisms in 3′UTRs of ADME genes in 305 breast cancer women treated with FAC regime. Clinical endpoints of this study were: overall survival (OS), progression-free survival (PFS), recurrence-free survival (RFS) and overall response defined as treatment failure-free survival (TFFS). The shortened OS was connected with the presence of NR1/2 rs3732359 AA, SLC22A16 rs7756222 CC, as well as SLC22A16 rs9487402 allele G and clinical factors belonging to TNM classification: tumor size >1 cm, nodal involvement and presence of metastases. PFS was related to two polymorphisms PGR rs1824125 GG, PGR rs12224560 CC and SLC22A16 rs7756222 CC as well as preexisting metastases. The RFS was shortened due to the DPYD rs291593 CC, AKR1C3 rs3209896 AG and negative expression of PGR. The presence of ALDH5A1 rs1054899 allele A, lack of pre-chemotherapy surgery and negative status of PGR correlated with worse treatment response. The germline variants commonly present in the population are important factors determining the response to treatment. We observed the effect of the accumulation of genetic and clinical factors on poor survival prognosis and overall treatment response. Breast cancer usually affects women in postmenopausal period, although it is diagnosed increasingly in younger patients often in advanced clinical stages 1. The 5-year survival is around 80% in developed countries 2. Therapeutic strategies for breast cancer include targeted therapy, hormone therapy, radiotherapy, surgery and chemotherapy 1,3. Toxicity and resistance to chemotherapeutic drugs are common problems observed in patients during and after treatment. Lack of sensitivity to chemotherapy is most often associated with dysfunction of protein transporters that remove chemotherapeutic agents from the cells or DNA repair processes 4. The response to systemic treatment is different in patients with the same type of cancer, similar stage of disease and treated with the same medications. Lack of chemotherapy response is observed as cancer-related mortality, disease progression or recurrence 5,6. Metabolism, absorption, distribution and excretion (ADME processes) of drugs are regulated by genes and proteins responsible for biotransformation and metabolic elimination of drugs (enzymes cytochrome P450). Also, proteins belonging to ATP binding cassette (ABC) and solute carrier (SLC) control influx or efflux of toxin and medicines and their cellular distribution 7,8. The expression of ADME genes is regulated at the transcriptional and translational levels. In addition, they undergo posttranslational modifications. ADME dysfunction may lead to reduced drug efficacy or to an adverse drug reaction in pharmacotherapy 9,10. Genetic and epigenetic transformations of ADME genes can modulate the activity and therapeutic effects of chemotherapy and underline interpatient differences in response to therapy 5,11-13 .

show abstract

Genetic polymorphisms in oxidative stress‐related genes are associated with outcomes following treatment for aggressive B‐cell non‐Hodgkin lymphoma

Cited by 26 publications

References 47 publications

Oxidative Stress-Related Gene Polymorphisms Are Associated With Hepatitis B Virus-Induced Liver Disease in the Northern Chinese Han Population

Oxidative Stress-Related Gene Polymorphisms Are Associated With Hepatitis B Virus-Induced Liver Disease in the Northern Chinese Han Population

Study of gene polymorphisms as predictors of treatment efficacy and toxicity in patients with indolent non‐hodgkin lymphomas and mantle cell lymphoma receiving bendamustine and rituximab

Genetic 3′UTR variations and clinical factors significantly contribute to survival prediction and clinical response in breast cancer patients

Contact Info

Product

Resources

About