Genetic polymorphisms associated with urinary tract infection in children and adults: a systematic review and meta-analysis

Yu, Jiakun; Varella Pereira, Glaucia Miranda; Allen-Brady, Kristina; Cuffolo, Romana; Siddharth, Aditi; Koch, Marianne; Chua, John W.F.; Sorrentino, Felice; Dytko, Oskar; Ng, Kaa-Yung; Violette, Philippe; Khullar, Vik; Wang, Zhan Tao; Cartwright, Rufus

doi:10.1016/j.ajog.2023.12.018

Cited by 1 publication

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“…Following a systematic review and meta-analysis [ 15 ] of prior gene association studies, we identified previously suggested risk variants for rUTI, VDR rs228570, VDR rs731236, VDR rs1544410, VDR rs7975232, CXCR1 rs2234671, CXCR2 rs11574750 and PSCA rs297388.…”

Section: Methodsmentioning

confidence: 99%

VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract Infections in Women: Genetic Association Study

Sarker,

Pereira,

Khullar

et al. 2024

Int Urogynecol J

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Introduction and hypothesis Urinary tract infection (UTI) is one of the most common human infections. Evidence suggests that there might be a genetic predisposition to UTI. Previous small candidate gene studies have suggested that common variants in genes involved in the immune response to UTI could increase susceptibility to the development of recurrent UTI (rUTI). The objective was to conduct a gene association study to replicate previous gene association studies identifying single nucleotide polymorphisms (SNPs) putatively associated with rUTI in adult women. Methods Women with a history of rUTI and healthy controls were recruited (n = 1,008) from gynaecology outpatient clinics. Participants completed a signed consent form and questionnaire for phenotyping. DNA was extracted from blood or saliva samples for each participant. Putative associated SNPs were identified from a comprehensive systematic review of prior gene association studies. Primers for each selected SNP were designed, and genotyping was conducted using a competitive polymerase chain reaction (PCR) method. The Chi-squared test was used to assess the association between each variant and rUTI. Genotyping quality was assessed by checking for deviation from Hardy–Weinberg equilibrium. Results We found no association between SNPs tested in the VDR (p = 0.16, p = 0.09, p = 0.36), CXCR1 (p = 0.09), CXCR2 (p = 0.39), PSCA (p = 0.74) genes, and rUTI in adult women. Conclusions To our knowledge, this is the largest study to date, finding no significant associations. Previously reported positive associations may have been due to type 1 error, or genotyping errors. Future studies should adjust for confounders and employ adequate sample sizes. A greater understanding of the genetic components associated with rUTI may influence future treatment guidelines and screening for susceptible patients.

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Section: Methodsmentioning

confidence: 99%