Genetic polymorphisms as predictors of methotrexate toxicity: literature review
G. A. Radzhabova,
T. T. Valiev,
Yu. E. Ryabukhina
et al.
Abstract:Background. A significant advancement in the treatment of high-grade aggressive non-Hodgkin’s lymphomas and acute lymphoblastic leukemia is the inclusion of high-dose (1000–5000 mg/m2) methotrexate in the treatment protocol. This approach has significantly increased the long-term survival rate, but it has been associated with toxicity, requiring supportive care. Factors that predict toxicity were identified, including genes involved in the metabolism (MTHFR) or transport (SLCO1B1) of methotrexate. The analysis… Show more
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