Genetic polymorphism study at 15 autosomal locus in central Indian population

Shrivastava, Pankaj; Jain, Toshi; Trivedi, Veena Ben

doi:10.1186/s40064-015-1364-1

Cited by 51 publications

(24 citation statements)

References 38 publications

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“…After DNA extraction and PCR, analysis was performed on 3500XL genetic analyzer, and statistical evaluation was done as described before [ 4 ]. The peak height threshold was 50 RFU for heterozygous and 200 RFU for homozygous alleles.…”

Section: Descriptionmentioning

confidence: 99%

Forensic genetic analysis of population of Madhya Pradesh with PowerPlex Fusion 6C™ Multiplex System

et al. 2019

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Performance of PowerPlex Fusion 6C kit (PP F6C) was assessed in 374 unrelated individuals belonging to Madhya Pradesh, an Indian state. The study evaluated the forensic parameters for the loci included in PP F6C Multiplex System. The combined discrimination power (CPD) and combined exclusion power (CPE) were 1 and 0.999999995, respectively, for all 23 autosomal STR loci. SE33 showed the greatest power of discrimination (0.990) in the studied population, whereas TPOX showed the lowest (0.843). The availability of three Y-STR loci in the Multiplex System is suitable for assessing male contribution and amelogenin deletion in a single Multiplex PCR simultaneously. The study also presents the first global report on polymorphism in the Indian population on SE 33 autosomal STR loci and PP Fusion 6C Multiplex System. The results revealed that the studied STR Multiplex System is highly polymorphic and suitable for forensic purposes. Electronic supplementary material The online version of this article (10.1007/s00414-019-02017-0) contains supplementary material, which is available to authorized users.

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Section: Descriptionmentioning

confidence: 99%

Forensic genetic analysis of population of Madhya Pradesh with PowerPlex Fusion 6C™ Multiplex System

et al. 2019

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“…The allele frequencies at the 15 autosomal STRs in the Lahore-Christian population were compared with those from 16 other populations using population differentiation test as shown in Supplementary Table 4 . Significant differences were observed after Boneferroni’s correction ( p ≤ 0.0002) at 15/15 loci with Mongol, 14/15 African American 26 , 27 , Caucasian (12/15) 27 , Uganda Yousafzai and Kashmiri (11/15) 16 , 18 , 28 , Balochi, Punjabi, central India (7/15) 14 , 23 , 38 . While differences at small numbers of loci for Nepalese, Sindhi (3/15), Karnataka and Bangladeshi (2/15) 21 , 24 , 25 , 39 were observed.…”

Section: Resultsmentioning

confidence: 99%

Population genetic portrait of Pakistani Lahore-Christians based on 32 STR loci

Rubab

Shafique

Javed

et al. 2020

Sci Rep

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Phylogenetic relationship and the population structure of 500 individuals from the Christian community of Lahore, Pakistan, were examined based on 15 autosomal short tandem repeats (STRs) using the AmpFℓSTR Identifiler Plus PCR Amplification Kit and our previously published Y-filer kit data (17 Y-STRs) of same samples. A total of 147 alleles were observed in 15 loci and allele 11 at the TPOX locus was the most frequent with frequency value (0.464). The data revealed that the Christian population has unique genetic characteristics with respect to a few unusual alleles and their frequencies relative to the other Pakistani population. Significant deviations from Hardy–Weinberg equilibrium were found at two loci (D13S317, D18S51) after Boneferroni’s correction (p ≤ 0.003). The combined power of discrimination, combined power of exclusion and cumulative probability of matching were 0.999999999999999978430815060354, 0.999995039393942 and 2.15692 × 10−17, respectively. On the bases of genetic distances, PCA, phylogenetic and structure analysis Lahore-Christians appeared genetically more associated to south Asian particularly Indian populations like Tamil, Karnataka, Kerala and Andhra Pradesh than rest of global populations.

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“…A neighbour joining (NJ) tree (Fig. 2 a) based on the Nei's genetic distance, constructed using POPTREE-2 software, was used to investigate the genetic affinity between the studied (admixed and Teli ) populations and the reported Indian populations namely, the Konkanastha Brahmins (Maharashtra) [ 22 ]; the Mahadev Kolis (Maharashtra) [ 22 ]; the Iyengars (Tamil Nadu) [ 22 ]; the Kurumans (Tamil Nadu) [ 22 ]; the Yerukulas (Andhra Pradesh) [ 23 ]; the Koras (West Bengal) [ 24 ]; the Baniyas (Punjab) [ 25 ]; the population of Jharkhand [ 26 ]; the population of Uttar Pradesh [ 27 ]; the population of Rajasthan [ 28 ]; the populations of Central India [ 29 ]; and the pooled populations belonging to the geographical boundaries of India [ 30 ]. The NJ tree revealed that the studied admixed and Teli populations of Maharashtra pooled into one cluster with the Konkanastha Brahmin s of Maharashtra and the Kurumans of Tamil Nadu.…”

Section: Main Textmentioning

confidence: 99%

A study of genomic diversity in populations of Maharashtra, India, inferred from 20 autosomal STR markers

et al. 2021

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Objective This study was planned to evaluate the genetic diversity in the admixed and Teli (a Hindu caste) populations of Maharashtra, India using 20 autosomal Short Tandem Repeat (STR) genetic markers. We further investigated the genetic relatedness of the studied populations with other Indian populations. Results The studied populations showed a wide range of observed heterozygosity viz. 0.690 to 0.918 for the admixed population and 0.696 to 0.942 for the Teli population. This might be due to the multi-directional gene flow. The admixed and Teli populations also showed a high degree polymorphism which ranged from 0.652 to 0.903 and 0.644 to 0.902, respectively. Their combined value of matching probability for all the studied loci was 4.29 × 10–25 and 5.01 × 10–24, respectively. The results of Neighbor-Joining tree and Principal Component Analysis showed that the studied populations clustered with the general populations of Jharkhand, UttarPradesh, Rajasthan and Central Indian States, as well as with the specific populations of Maharashtra (Konkanastha Brahmins) and Tamil Nadu (Kurmans). Overall, the obtained data showed a high degree of forensic efficacy and would be useful for forensic applications as well as genealogical studies.

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Genetic polymorphism study at 15 autosomal locus in central Indian population

Cited by 51 publications

References 38 publications

Forensic genetic analysis of population of Madhya Pradesh with PowerPlex Fusion 6C™ Multiplex System

Forensic genetic analysis of population of Madhya Pradesh with PowerPlex Fusion 6C™ Multiplex System

Population genetic portrait of Pakistani Lahore-Christians based on 32 STR loci

A study of genomic diversity in populations of Maharashtra, India, inferred from 20 autosomal STR markers

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